Fuquan Zhang
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View article: Magnetic resonance-guided online adaptive stereotactic body radiotherapy for advanced inoperable pancreatic cancer: a prospective study
Magnetic resonance-guided online adaptive stereotactic body radiotherapy for advanced inoperable pancreatic cancer: a prospective study Open
View article: Identifying Druggable Inflammatory Proteins Causally Contributing to Parkinson's Disease
Identifying Druggable Inflammatory Proteins Causally Contributing to Parkinson's Disease Open
Background Inflammatory mechanisms are critically engaged in the pathogenesis of Parkinson's disease (PD). The objective of this research was to detect circulating inflammatory proteins that potentially elevate the susceptibility to PD. Me…
View article: MR-Guided Adaptive Stereotactic Ablative Radiotherapy for Postoperative Recurrent and Metastatic Pancreatic Cancer: Early Efficacy and Toxicity Outcomes
MR-Guided Adaptive Stereotactic Ablative Radiotherapy for Postoperative Recurrent and Metastatic Pancreatic Cancer: Early Efficacy and Toxicity Outcomes Open
View article: 3D printing technology in gynecological brachytherapy
3D printing technology in gynecological brachytherapy Open
Over the past decade, the advancement in three-dimensional (3D) printing technology has introduced innovative methodology in gynecological brachytherapy, offering new approaches to improve treatment outcomes for patients with gynecological…
View article: Moderately hypofractionated online adaptive radiotherapy (SWIFT-1) in cervical cancer patients: study protocol for a multi-centered, open-label, two-arm, phase III, randomized controlled study
Moderately hypofractionated online adaptive radiotherapy (SWIFT-1) in cervical cancer patients: study protocol for a multi-centered, open-label, two-arm, phase III, randomized controlled study Open
This trial was registered at ClincalTrials.gov (NCT06641635) on October 12, 2024.
View article: Multi-omics analyses construct an inflammatory response based prognostic gene signature for cervical cancer and suggest tumor infiltrating monocytes subgroups as key players
Multi-omics analyses construct an inflammatory response based prognostic gene signature for cervical cancer and suggest tumor infiltrating monocytes subgroups as key players Open
Background Inflammatory response in the tumor micro-environment contributes to the progression and treatment response of various types of cancers. However, for cervical cancer, a type of cancer initiated by the infection of HPV, the clinic…
View article: Pancreatic metastasis from cervical cancer: A case report and literature review
Pancreatic metastasis from cervical cancer: A case report and literature review Open
Cervical cancer metastasis to the pancreas is rare, and the clinical manifestations are variable and contingent upon the location of the metastasis. Consequently, certain patients may be overlooked due to the absence of overt clinical symp…
View article: Does the addition of radiation to adjuvant chemotherapy improve the survival for early‐stage (tumor size ≤4 cm) small cell neuroendocrine carcinoma of the cervix after surgery? A population‐based study
Does the addition of radiation to adjuvant chemotherapy improve the survival for early‐stage (tumor size ≤4 cm) small cell neuroendocrine carcinoma of the cervix after surgery? A population‐based study Open
Background To assess the potential benefit of adding radiotherapy to adjuvant chemotherapy in patients with early‐stage small cell neuroendocrine carcinoma of the cervix (SCNEC) (tumor size ≤4 cm) after surgery. Methods The Surveillance, E…
View article: Deep Inspiratory Breath-Hold Technique for Patients with Left-Sided Breast Cancer: Dosimetric Analysis, Clinical Evaluation, and Prediction
Deep Inspiratory Breath-Hold Technique for Patients with Left-Sided Breast Cancer: Dosimetric Analysis, Clinical Evaluation, and Prediction Open
Introduction Breast radiotherapy is associated with a higher risk of cardiac diseases. Although deep inspiration breath-hold (DIBH) reduces the heart dose, it is underutilized. The selection of proper candidates for DIBH remains an unresol…
View article: Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor
Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor Open
Inflammatory myofibroblastic tumor (IMT) is a rare spindle‐cell neoplasm. IMT currently suffers from a paucity of standardized diagnostic and therapeutic guidelines. The Chinese expert consensus committee on the diagnosis and treatment of …
View article: Reduction of subclinical acute cardiac injury through DIBH radiotherapy: a single-institution real-world clinical cohort analysis
Reduction of subclinical acute cardiac injury through DIBH radiotherapy: a single-institution real-world clinical cohort analysis Open
The implementation of DIBH has been demonstrated to reduce the proportion of patients experiencing subclinical acute cardiac injury, with a higher proportion of patients returning to normalcy after one year. This finding suggests the poten…
View article: Land-Unet: A deep learning network for precise segmentation and identification of non-structured land use types in rural areas for green urban space analysis
Land-Unet: A deep learning network for precise segmentation and identification of non-structured land use types in rural areas for green urban space analysis Open
Land Use and Land Cover Change (LUCC) have become popular research topics in the environmental field. With the development of artificial intelligence technology, many downstream applications based on intelligent urban–rural semantic analys…
View article: Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism
Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism Open
According to the data in this study, it can be said that TPV can be used to distinguish recurrence from no-recurrence. Most importantly, TPV can be used to identify SHPT recurrence.
View article: Clinical outcomes analysis of image-guided brachytherapy as definitive treatment for inoperable endometrial cancer
Clinical outcomes analysis of image-guided brachytherapy as definitive treatment for inoperable endometrial cancer Open
View article: A phase I clinical trial evaluating the application of hydrogel in reducing rectal dose during cervical cancer brachytherapy
A phase I clinical trial evaluating the application of hydrogel in reducing rectal dose during cervical cancer brachytherapy Open
The application of the hydrogel effectively increased the distance between the cervix and rectum in brachytherapy for cervical cancer, limiting the rectal dose without increasing doses to other critical organs. In the short term, no severe…
View article: A dosimetric comparison of brachytherapy sources for endometrial cancer: an electronic brachytherapy and an iridium-192 source with multichannel cylinders and a three-dimensional technique
A dosimetric comparison of brachytherapy sources for endometrial cancer: an electronic brachytherapy and an iridium-192 source with multichannel cylinders and a three-dimensional technique Open
In conclusion, under the premise of a three-dimensional brachytherapy plan, for patients receiving multichannel vaginal applicator brachytherapy, compared with IBT, EBT could reduce the dose to the surrounding organs at risk while maintain…
View article: Comparison of outcomes between early-stage cervical cancer patients without high-risk factors undergoing adjuvant concurrent chemoradiotherapy and radiotherapy alone after radical surgery
Comparison of outcomes between early-stage cervical cancer patients without high-risk factors undergoing adjuvant concurrent chemoradiotherapy and radiotherapy alone after radical surgery Open
Purpose For patients with early-stage cervical cancer without high-risk factors, there is no consensus regarding the optimal postoperative treatment regimen and whether postoperative concurrent radiochemotherapy (CCRT) is superior to radio…
View article: Pelvic target volume inter-fractional motion during radiotherapy for cervical cancer with daily iterative cone beam computed tomography
Pelvic target volume inter-fractional motion during radiotherapy for cervical cancer with daily iterative cone beam computed tomography Open
View article: Study Design and Rationale of the ECMC-GART Phase 3 Clinical Study: Early-Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions
Study Design and Rationale of the ECMC-GART Phase 3 Clinical Study: Early-Stage Endometrial Cancer Based on Molecular Classification and Traditional Risk Stratification to Guide Adjuvant Radiotherapy Decisions Open
Background: Endometrial cancer (EC) represents a prevalent malignancy amongst women on a global scale, with adjuvant therapy strategy remaining inconsistent and controversial. Identifying subtypes integrated with molecular characteristics …
View article: Clinical characteristics and radiation therapy modality of younger patients with early-stage endometrial cancer, a multicenter study in China’s real world
Clinical characteristics and radiation therapy modality of younger patients with early-stage endometrial cancer, a multicenter study in China’s real world Open
Background Endometrial cancer is a prevalent gynecologic malignancy found in postmenopausal women. However, in the last two decades, the incidence of early-stage has doubled in women under 40 years old. This study aimed to investigate the …
View article: Clinical Guidelines for the Prevention and Treatment of Radiation‐induced Bladder Injury
Clinical Guidelines for the Prevention and Treatment of Radiation‐induced Bladder Injury Open
Radiation‐induced bladder injury is a common complication after pelvic radiotherapy. Few studies exist on diagnosing and treating radiation‐induced bladder injury, with no established guidelines or consensus in China or internationally. Cl…
View article: Prospects for daily online adaptive radiotherapy for cervical cancer: Auto-contouring evaluation and dosimetric outcomes
Prospects for daily online adaptive radiotherapy for cervical cancer: Auto-contouring evaluation and dosimetric outcomes Open
View article: Evaluation of PTV margins with daily iterative online adaptive radiotherapy for postoperative treatment of endometrial and cervical cancer: a prospective single-arm phase 2 study
Evaluation of PTV margins with daily iterative online adaptive radiotherapy for postoperative treatment of endometrial and cervical cancer: a prospective single-arm phase 2 study Open
View article: Risk Stratification of Postoperative Adjuvant Therapy for Endometrial Cancer Patients (POAT-ENDORISK): Development and Validation of a Bayesian Network Model
Risk Stratification of Postoperative Adjuvant Therapy for Endometrial Cancer Patients (POAT-ENDORISK): Development and Validation of a Bayesian Network Model Open
View article: Exploration of radiotherapy strategy for brain metastasis patients with driver gene positivity in lung cancer
Exploration of radiotherapy strategy for brain metastasis patients with driver gene positivity in lung cancer Open
Objective: To assess the disparities in effectiveness and identify outcome predictors in the treatment of a targeted-first and radiotherapy-first regimen with driver gene-positive lung cancer brain metastases. Materials and Metho…
View article: Is Prophylactic Radiotherapy to the Lymphatic Drainage Area Necessary for Patients With Stage III Ovarian Cancer After Chemotherapy Following Surgery?
Is Prophylactic Radiotherapy to the Lymphatic Drainage Area Necessary for Patients With Stage III Ovarian Cancer After Chemotherapy Following Surgery? Open
Background For patients with stage III epithelial ovarian cancer, there are limited studies on the effects of postoperative adjuvant radiotherapy (RT). Here we assessed the therapeutic efficacy and toxicity of postoperative radiotherapy to…
View article: A dosimetric comparison of brachytherapy sources for endometrial cancer: Iridium-192 and an electronic brachytherapy source with multichannel cylinders and a three-dimensional technique
A dosimetric comparison of brachytherapy sources for endometrial cancer: Iridium-192 and an electronic brachytherapy source with multichannel cylinders and a three-dimensional technique Open
Background and purpose For patients with postoperative endometrial cancer (EC), Ir192 vaginal brachytherapy (IBT) was commonly used. We would devise a novel multi-channel vaginal applicator which could be equipped to an electronic brachyth…
View article: Risk Factors for Nodal Failure in Patients with FIGO IIIC Cervical Cancer Receiving Definitive Image-Guided Radiotherapy
Risk Factors for Nodal Failure in Patients with FIGO IIIC Cervical Cancer Receiving Definitive Image-Guided Radiotherapy Open
Background: Nodal failure is a major failure pattern for patients with FIGO IIIC cervical cancer, which is further associated with worse survival. This study was designed to investigate risk factors for nodal failure in FIGO IIIC cervical …
View article: Efficacy of Whole-Brain Radiotherapy Plus Simultaneous Integrated Boost (SIB-WBRT) for brain metastases
Efficacy of Whole-Brain Radiotherapy Plus Simultaneous Integrated Boost (SIB-WBRT) for brain metastases Open
Objective: To investigate the outcomes of SIB-WBRT in patients with brain metastases and analyze the impact of some factors on prognosis. Methods: This single-arm retrospective study analyzed patients with brain metastases treated with rec…
View article: Postoperative Radiotherapy to Abdominal and Pelvic Lymphatic Drainage Area for Stage III Epithelial Ovarian Cancer: A Sharp Tool to Prolong Disease-Free Survival Time
Postoperative Radiotherapy to Abdominal and Pelvic Lymphatic Drainage Area for Stage III Epithelial Ovarian Cancer: A Sharp Tool to Prolong Disease-Free Survival Time Open