Jianzhong Zhang
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View article: Impact of IS26 mobilization on genetic manipulation of multidrug-resistant Acinetobacter baumannii
Impact of IS26 mobilization on genetic manipulation of multidrug-resistant Acinetobacter baumannii Open
Introduction Multidrug-resistant Acinetobacter baumannii poses significant challenges for genetic manipulation, historically hindering research on this organism. Methods To elucidate the factors contributing to these difficulties, comA and…
View article: An Atypical Presentation of Basal Cell Carcinoma: A Giant Verrucous Ulcer on the Upper Arm
An Atypical Presentation of Basal Cell Carcinoma: A Giant Verrucous Ulcer on the Upper Arm Open
Giant basal cell carcinoma (GBCC) is a rare and clinically aggressive subtype of BCC. We report an unusual case of a 71-year-old male with a 30-year history of a slowly enlarging tumor on the extensor surface of his left upper arm. The les…
View article: Optical Fiber TFBG Glucose Biosensor via pH-Sensitive Polyelectrolyte Membrane
Optical Fiber TFBG Glucose Biosensor via pH-Sensitive Polyelectrolyte Membrane Open
A novel glucose biosensor is developed based on a tilted fiber Bragg grating (TFBG) functionalized with a pH-responsive polyelectrolyte multilayer membrane, onto which glucose oxidase (GOD) is immobilized. The sensing film is constructed v…
View article: Biphasic Adaptations of Gastric Epithelial Cells in Chronic H. pylori Infection from Stress to Tolerance
Biphasic Adaptations of Gastric Epithelial Cells in Chronic H. pylori Infection from Stress to Tolerance Open
Helicobacter pylori (H. pylori) is a well-known pathogen associated with chronic gastric infection, progressing from gastritis to gastric adenocarcinoma, but the dynamic phenotypic and molecular characteristics of gastric epithelial cells …
View article: Hyperinvasive Neisseria meningitidis in China Originates from Commensals in Healthy Carriers
Hyperinvasive Neisseria meningitidis in China Originates from Commensals in Healthy Carriers Open
In June 2024, a novel hyperinvasive strain of Neisseria meningitidis (N. meningitidis) caused the deaths of two middle school students in Qinghai Province, China. This is the first hyperinvasive strain to emerge in the country since 2003 a…
View article: Preliminary assessment of the therapeutic potential of staphylococcal enterotoxin-like W via biological activity and TCR binding sites analysis
Preliminary assessment of the therapeutic potential of staphylococcal enterotoxin-like W via biological activity and TCR binding sites analysis Open
Staphylococcal enterotoxin-like W (SElW) is a novel, widely prevalent enterotoxin-like protein that functions as a classical staphylococcal superantigen (SAg) and has been shown to exacerbate infections caused by the S. aureus epide…
View article: Relationship between albumin-corrected anion gap and short- and medium-term all-cause mortality in heart failure patients with a single ICU admission
Relationship between albumin-corrected anion gap and short- and medium-term all-cause mortality in heart failure patients with a single ICU admission Open
Studies examining the role of albumin-corrected anion gap (ACAG), an emerging promising prognostic biomarker for critical illnesses, in predicting mortality of ICU patients with heart failure (HF) are limited. We aimed to analyze the relat…
View article: Correction: Biologics for the Treatment of Moderate-to-Severe Plaque Psoriasis: A Systematic Review and Network Meta-analysis
Correction: Biologics for the Treatment of Moderate-to-Severe Plaque Psoriasis: A Systematic Review and Network Meta-analysis Open
View article: [Impact of outpatient services utilization of heart failure patients on hospitalization rate and its threshold effect: Taking patients with Urban Employee Basic Medical Insurance in Zhejiang Province as an example].
[Impact of outpatient services utilization of heart failure patients on hospitalization rate and its threshold effect: Taking patients with Urban Employee Basic Medical Insurance in Zhejiang Province as an example]. Open
There is a threshold effect of prior-year annual outpatient service utilization on the current year' s annual hospitalization rate in heart failure patients. These results have important implications for designing outpatient health insuran…
View article: Spatial structure and influencing factors of agricultural civilization heritage in the Yellow River Basin
Spatial structure and influencing factors of agricultural civilization heritage in the Yellow River Basin Open
View article: Association of albumin-corrected anion gap with mortality in ICU patients with heart failure and acute kidney injury: analysis of the MIMIC-IV database
Association of albumin-corrected anion gap with mortality in ICU patients with heart failure and acute kidney injury: analysis of the MIMIC-IV database Open
View article: Detection of Inter-Turn Short-Circuit Faults for Inverter-Fed Induction Motors Based on Negative-Sequence Current Analysis
Detection of Inter-Turn Short-Circuit Faults for Inverter-Fed Induction Motors Based on Negative-Sequence Current Analysis Open
Inter-turn short-circuit faults in induction motors might lead to overheating, torque imbalances, and eventual motor failure. This paper presents a fault detection framework for accurately identifying ITSC faults under various operating co…
View article: Pathogenicity of invasive and non-invasive CC4821 Neisseria meningitidis
Pathogenicity of invasive and non-invasive CC4821 Neisseria meningitidis Open
Neisseria meningitidis (N. meningitidis) is an opportunistic pathogen that typically colonizes the mucosal surfaces of the nasopharynx. Under certain conditions, N. meningitidis can lead to invasive meningococcal disease (IMD). Nevertheles…
View article: Hypotrichosis 14: novel variants of the LSS gene in five Chinese families and insights from literature review
Hypotrichosis 14: novel variants of the LSS gene in five Chinese families and insights from literature review Open
Our comprehensive summary of phenotypes caused by LSS gene variants not only enriches the existing knowledge on congenital hypotrichosis 14 but also provides crucial guidance for more accurate genetic counseling and potentially new directi…
View article: Unraveling the role of HIF2α in melanoma progression and epithelial–mesenchymal transition
Unraveling the role of HIF2α in melanoma progression and epithelial–mesenchymal transition Open
Melanoma is a highly heterogeneous and aggressive malignancy. Hypoxia within the tumor microenvironment is closely associated with tumor progression. However, the role of hypoxia-inducible factor 2α (HIF2α), a key transcription factor, in …
View article: Origin of <i>Neisseria meningitidis</i> clonal complex 4821
Origin of <i>Neisseria meningitidis</i> clonal complex 4821 Open
Neisseria meningitidis (N. meningitidis) is the causative agent of human invasive meningococcal disease (IMD). Clonal complex (CC) 4821 is a unique genetic cluster of N. meningitidis that emerged two decades ago in Anh…
View article: Ten-year follow-up of atypical small acinar hyperplasia cases diagnosed by initial prostate biopsy
Ten-year follow-up of atypical small acinar hyperplasia cases diagnosed by initial prostate biopsy Open
For the patients with ASAP diagnosed by the initial biopsy, the risk of subsequent diagnosis of clinically significant prostate cancer is high. Combined with the high dropout rate and postoperative pathological escalation rate in this stud…
View article: Biologics for the Treatment of Moderate-to-Severe Plaque Psoriasis: A Systematic Review and Network Meta-analysis
Biologics for the Treatment of Moderate-to-Severe Plaque Psoriasis: A Systematic Review and Network Meta-analysis Open
The investigated biologics demonstrated improved efficacy and QoL relative to placebo at week 28, with no increased risk of SAEs vs. placebo through week 16. At week 28, efficacy of tildrakizumab, risankizumab, and guselkumab was comparabl…
View article: Detection and Localization of Rotor Winding Inter-Turn Short Circuit Fault in DFIG Using Zero-Sequence Current Component Under Variable Operating Conditions
Detection and Localization of Rotor Winding Inter-Turn Short Circuit Fault in DFIG Using Zero-Sequence Current Component Under Variable Operating Conditions Open
DFIG rotor windings face high stress and transients from back-to-back converters, causing inter-turn short circuit (ITSC) faults. Rapid rotor-side dynamics, combined with the unique capability of DFIG to operate in multiple modes, make the…
View article: Quercetin alleviates cerebral ischemia and reperfusion injury in hyperglycemic animals by reducing endoplasmic reticulum stress through activating SIRT1
Quercetin alleviates cerebral ischemia and reperfusion injury in hyperglycemic animals by reducing endoplasmic reticulum stress through activating SIRT1 Open
Hyperglycemia aggravates cerebral ischemic reperfusion injury (CIRI). Neuroprotective drugs that are effective in reducing CIRI in animals with normoglycemic condition are ineffective in ameliorating CIRI under hyperglycemic condition. Thi…
View article: Multiple automated machine-learning prediction models for postoperative reintubation in patients with acute aortic dissection: a multicenter cohort study
Multiple automated machine-learning prediction models for postoperative reintubation in patients with acute aortic dissection: a multicenter cohort study Open
Introduction Reintubation is an adverse postoperative complication in patients with Type A aortic dissection (AAD) that correlates to poor outcomes. This study aims to employ machine learning algorithms to establish a practical platform fo…
View article: Hypotrichosis 14: Novel variants of the LSS gene in five Chinese families and insights from literature review
Hypotrichosis 14: Novel variants of the LSS gene in five Chinese families and insights from literature review Open
Background: Congenital hypotrichosis 14 is a non-syndromic form of alopecia associated with mutations in the lanosterol synthase (LSS) gene. Recent studies have expanded the spectrum of LSS-related phenotypes, including congenital cataract…
View article: RdxA-independent mechanism of Helicobacter pylori metronidazole metabolism
RdxA-independent mechanism of Helicobacter pylori metronidazole metabolism Open
Introduction Metronidazole (MNZ) is widely used to treat Helicobacter pylori infection worldwide. However, due to excessive and repeated use, resistance rates have exceeded 90% in some regions. The mechanisms of MNZ resistance have been ex…
View article: Safety, Pharmacokinetics, and Efficiency of JS005, a Novel Anti-interleukin-17A Monoclonal Antibody, in Healthy Chinese Adults and Patients with Moderate to Severe Psoriasis
Safety, Pharmacokinetics, and Efficiency of JS005, a Novel Anti-interleukin-17A Monoclonal Antibody, in Healthy Chinese Adults and Patients with Moderate to Severe Psoriasis Open
JS005 is a novel anti-IL-17A monoclonal antibody. A Phase Ia study (Study 1) in healthy adults, followed by a Phase Ib/II study (Study 2) in patients with moderate to severe plaque psoriasis (PsO), were designed to evaluate the safety, eff…
View article: Successful treatment of a patient with multiple solar keratosis (AK) with highly differentiated squamous cell carcinoma across the face through the combination of operation and photodynamic therapy: A case report
Successful treatment of a patient with multiple solar keratosis (AK) with highly differentiated squamous cell carcinoma across the face through the combination of operation and photodynamic therapy: A case report Open
Actinic keratosis (AK) with multiple lesions on the face combined with well-differentiated squamous cell carcinoma is a severe skin lesion. Traditional treatment methods mainly rely on surgery. However, for a 92-year-old female patient, du…
View article: Efficacy and safety of topical finasteride spray solution in the treatment of Chinese men with androgenetic alopecia: A phase III, multicenter, randomized, double-blind, placebo-controlled study
Efficacy and safety of topical finasteride spray solution in the treatment of Chinese men with androgenetic alopecia: A phase III, multicenter, randomized, double-blind, placebo-controlled study Open
Background: Topical finasteride is a novel treatment for men with an androgenetic alopecia (AGA). This study aimed to evaluate the efficacy and safety of topical finasteride spray solution in Chinese men with AGA. Methods: This randomized,…
View article: A standardized protocol for modified platelet-rich plasma collection for the treatment of interstitial cystitis/bladder pain syndrome
A standardized protocol for modified platelet-rich plasma collection for the treatment of interstitial cystitis/bladder pain syndrome Open
Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and diagnostically challenging condition with limited treatment options and poor prognosis. Platelet-rich plasma (PRP) is a potential treatment for IC/BPS. Nonet…
View article: Efficacy and Safety of 611 in Chinese Adults with Moderate-to-Severe Atopic Dermatitis: Results from a Phase II Trial
Efficacy and Safety of 611 in Chinese Adults with Moderate-to-Severe Atopic Dermatitis: Results from a Phase II Trial Open
ClinicalTrials.gov, NCT05544591.
View article: Genomic epidemiology of dominant lineages of Streptococcus pyogenes emm types between 1993-2020, in China
Genomic epidemiology of dominant lineages of Streptococcus pyogenes emm types between 1993-2020, in China Open
Streptococcus pyogenes infections such as scarlet fever have increased in China since 2011. The genomic drivers of this increase are not known. The temporal clonal shifts within dominant emm12 and emm1 populations are unknown due to limite…
View article: Multiplex PCR–Mass Spectrometry Mini-Sequencing Technology Detected Antibiotic Resistance of Helicobacter pylori to Six Antibiotics
Multiplex PCR–Mass Spectrometry Mini-Sequencing Technology Detected Antibiotic Resistance of Helicobacter pylori to Six Antibiotics Open
The abuse of antibiotics has led to widespread resistance to Helicobacter pylori (H. pylori) in the population. There is an urgent need to establish a method to detect multiple antibiotic resistance rapidly. This study aimed to construct a…