Kun Li
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View article: IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling
IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling Open
Carver Trust COVID-19 Grant; CF Foundation Iowa RDP; NIH 1R01HL163024; K01HL140261; NIH R01AI129269; NIH P01AI060699; NIH Grant P30 DK-54759; Cystic Fibrosis Foundation PEZZUL20A1-KB; Stead Family Foundation.
View article: Liberating Exciton Transfer as a Pioneering Strategy to Construct Type I Photosensitizers for Hypoxia Deep-Seated Metastases Suppression
Liberating Exciton Transfer as a Pioneering Strategy to Construct Type I Photosensitizers for Hypoxia Deep-Seated Metastases Suppression Open
Type I photosensitizers (PSs) have revolutionized traditional photodynamic therapy for hypoxia tumors by eliminating oxygen dependence. Nevertheless, the current development of Type I PSs faces formidable obstacles stemming from the paucit…
BSL: A Unified and Generalizable Multitask Learning Platform for Virtual Drug Discovery from Design to Synthesis Open
Drug discovery is of great social significance in safeguarding human health, prolonging life, and addressing the challenges of major diseases. In recent years, artificial intelligence has demonstrated remarkable advantages in key tasks acr…
Exosomes: A Promising Cell-Free Therapeutic Tool for Treating Cutaneous Nerve Injuries and Promoting Wound Healing Open
The skin is the body’s largest organ. It serves various functions, including protection and metabolism. Due to its structure and location, it is more vulnerable to external physical and chemical damage than internal organs. Additionally, c…
Simulation analysis on airflow organization inside ship’s partitioned vegetable and fruit storage rooms Open
During the ocean voyage of the ship, the vegetable and fruit storage rooms must accommodate a wide variety of produce with different requirements for preservation temperature to meet the nutritional needs of the crew. Additionally, most sh…
View article: Vascular smooth muscle cell-derived SO2 sulphenylated interferon regulatory factor 1 to inhibit VSMC senescence
Vascular smooth muscle cell-derived SO2 sulphenylated interferon regulatory factor 1 to inhibit VSMC senescence Open
Background Vascular smooth muscle cell (VSMC) senescence is a critical driver of vascular aging and various age-related cardiovascular diseases. Endogenous sulfur dioxide (SO 2 ), a newly identified key cardiovascular gaseous signaling med…
Monitoring Acidification Preceding Aβ Deposition in Alzheimer's Disease Open
Amyloid beta (Aβ) is the primary early biomarker of Alzheimer's disease (AD), and since an acidic environment promotes Aβ aggregation, acidification plays a crucial role in AD progression. In this study, a novel acid‐responsive near‐infrar…
All‐Alkynyl Protected Rod‐Shaped Au<sub>9</sub>(AgCu)<sub>126</sub> Nanocluster with Remarkable Photothermal Conversion Open
High‐nuclearity intermetallic nanoclusters are important for investigating the evolution of alloy materials from atoms to plasmonic alloy nanoparticles. However, the synthesis of large‐size alloy nanoclusters (∼2 nm) is still challenging. …
All‐Alkynyl Protected Rod‐Shaped Au<sub>9</sub>(AgCu)<sub>126</sub> Nanocluster with Remarkable Photothermal Conversion Open
High‐nuclearity intermetallic nanoclusters are important for investigating the evolution of alloy materials from atoms to plasmonic alloy nanoparticles. However, the synthesis of large‐size alloy nanoclusters (∼2 nm) is still challenging. …
Graph-structured Small Molecule Drug Discovery Through Deep Learning: Progress, Challenges, and Opportunities Open
Due to their excellent drug-like and pharmacokinetic properties, small molecule drugs are widely used to treat various diseases, making them a critical component of drug discovery. In recent years, with the rapid development of deep learni…
Advances in non-invasive neuromodulation techniques for geriatric depression: A comprehensive review Open
The gradual aging of the global population is increasing the prevalence of geriatric depression, a severe mental disorder that imposes a significant burden on individuals and society. Conventional treatments such as pharmacotherapy and psy…
View article: Rational Design of NIR‐II Fluorescence/Photoacoustic Nanosensor Tailored for Mechanisms of Diabetes‐Related Breast Cancer
Rational Design of NIR‐II Fluorescence/Photoacoustic Nanosensor Tailored for Mechanisms of Diabetes‐Related Breast Cancer Open
Breast cancer (BC) is the second most common cause of cancer induced death worldwide. Current statistics has disclosed that the diabetic BC patients have significantly worse survival rate compared with nondiabetic BC patients. However, the…
Crystal structure of anthracen-9-yl(3,6-dimethoxynaphthalen-2-yl)methanone: Decisive factors for formation of two-fold helical molecular assemblies in three directions affording chiral crystal Open
The titled compound of 3-(anthracen-9-carbonylated) 2,7-dimethoxynaphthalene, anthracen-9-yl(3,6-dimethoxynaphthalen-2-yl)methanone, affords as chiral crystals belonging to P212121 space group. To investigate the leading factors of chiral …
TopLib: Building and searching top-down mass spectral libraries for proteoform identification Open
Mass spectral library search is a widely used approach for spectral identification in mass spectrometry (MS)-based proteomics. While numerous methods exist for building and searching bottom-up mass spectral libraries, there is a lack of so…
View article: Molecular Engineering of Xanthene Dyes with 3D Multimodal‐Imaging Ability to Guide Photothermal Therapy
Molecular Engineering of Xanthene Dyes with 3D Multimodal‐Imaging Ability to Guide Photothermal Therapy Open
Phototheranostics integrates light‐based diagnostic techniques with therapeutic interventions, offering a non‐invasive, precise, and swift approach for both disease detection and treatment. The efficacy of this approach hinges on the multi…
View article: Efficient removal of Sb(III) from aqueous solution using recyclable magnetic metal-organic frameworks Fe3O4@MIL-100 and Fe3O4@MIL-101
Efficient removal of Sb(III) from aqueous solution using recyclable magnetic metal-organic frameworks Fe3O4@MIL-100 and Fe3O4@MIL-101 Open
Antimony (Sb) pollution is becoming increasingly serious. The pollution of water bodies containing antimony poses a great threat to the ecological environment and human health. In this study, two types of magnetic metal-organic frameworks(…
View article: De Novo Construction of <i>pKa</i>‐Tunable Xanthene Molecules for pH Sensitive Fluorescence Navigation
De Novo Construction of <i>pKa</i>‐Tunable Xanthene Molecules for pH Sensitive Fluorescence Navigation Open
pH is spatiotemporal variable dynamically in physiological and pathological processes, and the tiny pH changes can result completely different physiological processes. However, the major drawbacks of conventional pH‐activatable probes are …
Genome-wide identification of pan-cancer common and cancer-specific alternative splicing events in 9 types of cancer Open
Alternative splicing (AS) has significant clinical relevance with cancers and is a potential source of neoepitopes. In this study, RNA-seq data of 94 solid tumor and matched adjacent normal tissues from 47 clinical patients covering nine c…
Unveiling the synergetic benefits of the tunneling technique using stapler tractor in precise resection of lung segments: a retrospective cohort study Open
Background Tunneling technique has shown preliminary promise in lung segmentectomy which requires the use of staplers in specific procedures. However, the obstacle when staples pass is the most obvious factor hindering the implementation a…
View article: IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo
IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo Open
Treatments available to prevent progression of virus-induced lung diseases, including coronavirus disease 2019 (COVID-19) are of limited benefit once respiratory failure occurs. The efficacy of approved and emerging cytokine signaling-modu…
View article: Sulfur dioxide inhibits mast cell degranulation by sulphenylation of galectin-9 at cysteine 74
Sulfur dioxide inhibits mast cell degranulation by sulphenylation of galectin-9 at cysteine 74 Open
Objectives Mast cell (MC) degranulation is a key process in allergic reactions and inflammatory responses. Aspartate aminotransferase 1 (AAT1)-derived endogenous sulfur dioxide (SO 2 ) is an important regulator of MC function. However, the…
View article: Purine‐Based Ir(III) Photosensitizers for Efficient Treatment of Periodontal Inflammation
Purine‐Based Ir(III) Photosensitizers for Efficient Treatment of Periodontal Inflammation Open
Photodynamic therapy (PDT) presents a promising approach for combating periodontitis, an infectious disease triggered by bacteria. However, the hypoxic environment within periodontal pockets poses challenges for PDT efficacy. In this study…