Phillip Zhe Sun
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View article: TMET-42. Fluid-suppressed APTw-CEST MRI enhances tumor-edema differentiation in malignant brain tumors
TMET-42. Fluid-suppressed APTw-CEST MRI enhances tumor-edema differentiation in malignant brain tumors Open
BACKGROUND Conventional Magnetic Resonance Imaging (MRI) struggles to distinguish tumor recurrence from non-neoplastic treatment-related changes (TRC) in patients with brain tumors. Amide Proton Transfer-weighted (APTw) imaging is a molecu…
View article: Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review
Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review Open
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a powerful imaging technique sensitive to tissue molecular composition, pH, and metabolic processes in situ. CEST MRI uniquely probes the physical…
View article: Improving standardization and accuracy of in vivo omega plot exchange parameter determination using rotating‐frame model‐based fitting of quasi‐steady‐state Z‐spectra
Improving standardization and accuracy of in vivo omega plot exchange parameter determination using rotating‐frame model‐based fitting of quasi‐steady‐state Z‐spectra Open
Purpose Although Ω‐plot‐driven quantification of in vivo amide exchange properties has been demonstrated, differences in scan parameters may complicate the fidelity of determination. This work systematically evaluated the use of quasi‐stea…
View article: Quasi‐steady‐state (<scp>QUASS</scp>) reconstruction enhances <scp><i>T</i><sub>1</sub></scp> normalization in apparent exchange‐dependent relaxation (<scp>AREX</scp>) analysis: A reevaluation of <scp><i>T</i><sub>1</sub></scp> correction in quantitative <scp>CEST MRI</scp> of rodent brain tumor models
Quasi‐steady‐state (<span>QUASS</span>) reconstruction enhances <span><i>T</i><sub>1</sub></span> normalization in apparent exchange‐dependent relaxation (<span>AREX</span>) analysis: A reevaluation of <span><i>T</i><sub>1</sub></span> correction in quantitative <span>CEST MRI</span> of rodent brain tumor models Open
Purpose The apparent exchange‐dependent relaxation (AREX) analysis has been proposed as an effective means to correct T 1 contribution in CEST quantification. However, it has been recognized that AREX T 1 correction is not straightforward …
View article: Specific and rapid guanidinium <scp>CEST</scp> imaging using double saturation power and <scp>QUASS</scp> analysis in a rodent model of global ischemia
Specific and rapid guanidinium <span>CEST</span> imaging using double saturation power and <span>QUASS</span> analysis in a rodent model of global ischemia Open
Purpose Guanidinium CEST is sensitive to metabolic changes and pH variation in ischemia, and it can offer advantages over conventional pH‐sensitive amide proton transfer (APT) imaging by providing hyperintense contrast in stroke lesions. H…
View article: <scp>3D</scp> CEST <scp>MRI</scp> with an unevenly segmented <scp>RF</scp> irradiation scheme: A feasibility study in brain tumor imaging
<span>3D</span> CEST <span>MRI</span> with an unevenly segmented <span>RF</span> irradiation scheme: A feasibility study in brain tumor imaging Open
Purpose To integrate 3D CEST EPI with an unevenly segmented RF irradiation module and preliminarily demonstrate it in the clinical setting. Methods A CEST MRI with unevenly segmented RF saturation was implemented, including a long primary …
View article: Numerical simulation‐based assessment of pH‐sensitive chemical exchange saturation transfer MRI quantification accuracy across field strengths
Numerical simulation‐based assessment of pH‐sensitive chemical exchange saturation transfer MRI quantification accuracy across field strengths Open
Chemical exchange saturation transfer (CEST) MRI detects dilute labile protons via their exchange with bulk water, conferring pH sensitivity. Based on published exchange and relaxation properties, a 19‐pool simulation was used to model the…
View article: Comparison of model‐free Lorentzian and spinlock model‐based fittings in quantitative CEST imaging of acute stroke
Comparison of model‐free Lorentzian and spinlock model‐based fittings in quantitative CEST imaging of acute stroke Open
Purpose CEST MRI detects complex tissue changes following acute stroke. Our study aimed to test if spinlock model‐based fitting of the quasi‐steady‐state (QUASS)‐reconstructed equilibrium CEST MRI improves the determination of multi‐pool s…
View article: Early Detection and Staging of Lung Fibrosis Enabled by Collagen-Targeted MRI Protein Contrast Agent
Early Detection and Staging of Lung Fibrosis Enabled by Collagen-Targeted MRI Protein Contrast Agent Open
Chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), are major leading causes of death worldwide and are generally associated with poor prognoses. The heterogeneous distributi…
View article: Use of multimodality imaging, histology, and treatment feasibility to characterize a transgenic Rag2-null rat model of glioblastoma
Use of multimodality imaging, histology, and treatment feasibility to characterize a transgenic Rag2-null rat model of glioblastoma Open
Many drugs that show potential in animal models of glioblastoma (GBM) fail to translate to the clinic, contributing to a paucity of new therapeutic options. In addition, animal model development often includes histologic assessment, but mu…
View article: Effects of a new thrombolytic compound LT3001 on acute brain tissue damage after focal embolic stroke in rats
Effects of a new thrombolytic compound LT3001 on acute brain tissue damage after focal embolic stroke in rats Open
LT3001 is a novel synthetic small molecule with thrombolytic and free radical scavenging activities. In this study, we tested the effects of LT3001 as a potential alternative thrombolytic in focal embolic ischemic stroke rat model. Stroke …
View article: In vivo <scp>pH</scp> mapping with omega plot‐based quantitative chemical exchange saturation transfer <scp>MRI</scp>
In vivo <span>pH</span> mapping with omega plot‐based quantitative chemical exchange saturation transfer <span>MRI</span> Open
Purpose Chemical exchange saturation transfer (CEST) MRI is promising for detecting dilute metabolites and microenvironment properties, which has been increasingly adopted in imaging disorders such as acute stroke and cancer. However, in v…
View article: Quasi–steady‐state amide proton transfer (QUASS APT) MRI enhances pH‐weighted imaging of acute stroke
Quasi–steady‐state amide proton transfer (QUASS APT) MRI enhances pH‐weighted imaging of acute stroke Open
Purpose Chemical exchange saturation transfer (CEST) imaging measurement depends not only on the labile proton concentration and pH‐dependent exchange rate but also on experimental conditions, including the relaxation delay and radiofreque…
View article: Review and consensus recommendations on clinical <scp>APT</scp>‐weighted imaging approaches at <scp>3T</scp>: Application to brain tumors
Review and consensus recommendations on clinical <span>APT</span>‐weighted imaging approaches at <span>3T</span>: Application to brain tumors Open
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed‐on standards …
View article: Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging
Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging Open
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a novel means for sensitive detection of dilute labile protons and chemical exchange rates. By sensitizing to pH‐dependent chemical exchange, CEST…
View article: Consistent depiction of the acidic ischemic lesion with APT MRI—Dual RF power evaluation of pH‐sensitive image in acute stroke
Consistent depiction of the acidic ischemic lesion with APT MRI—Dual RF power evaluation of pH‐sensitive image in acute stroke Open
Purpose Amide proton transfer‐weighted (APTw) MRI provides a non‐invasive pH‐sensitive image, complementing perfusion and diffusion imaging for refined stratification of ischemic tissue. Although the commonly used magnetization transfer (M…
View article: Demonstration of fast multi‐slice quasi‐steady‐state chemical exchange saturation transfer (QUASS CEST) human brain imaging at 3T
Demonstration of fast multi‐slice quasi‐steady‐state chemical exchange saturation transfer (QUASS CEST) human brain imaging at 3T Open
Purpose To combine multi‐slice chemical exchange saturation transfer (CEST) imaging with quasi‐steady‐state (QUASS) processing and demonstrate the feasibility of fast QUASS CEST MRI at 3T. Methods Fast multi‐slice echo planar imaging (EPI)…
View article: Pulseq‐CEST: Towards multi‐site multi‐vendor compatibility and reproducibility of CEST experiments using an open‐source sequence standard
Pulseq‐CEST: Towards multi‐site multi‐vendor compatibility and reproducibility of CEST experiments using an open‐source sequence standard Open
Purpose As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendo…
View article: Quasi–steady‐state CEST (QUASS CEST) solution improves the accuracy of CEST quantification: QUASS CEST MRI‐based omega plot analysis
Quasi–steady‐state CEST (QUASS CEST) solution improves the accuracy of CEST quantification: QUASS CEST MRI‐based omega plot analysis Open
Purpose CEST MRI omega plot quantifies the labile proton fraction ratio ( f r ) and exchange rate ( k sw ), yet it assumes long RF saturation time (Ts) and relaxation delay (Td). Our study aimed to test if a quasi–steady‐state (QUASS) CEST…
View article: Quasi‐steady state chemical exchange saturation transfer (QUASS CEST) analysis—correction of the finite relaxation delay and saturation time for robust CEST measurement
Quasi‐steady state chemical exchange saturation transfer (QUASS CEST) analysis—correction of the finite relaxation delay and saturation time for robust CEST measurement Open
Purpose CEST provides a MR contrast mechanism sensitizing to the exchange between dilute labile and bulk water protons. However, the CEST effect depends on the RF saturation duration and relaxation delay, which need to be long to reach its…
View article: Low-density lipoprotein receptor-related protein-1 (LRP1) targeting contrast-enhanced MRI as a novel strategy for epilepsy imaging
Low-density lipoprotein receptor-related protein-1 (LRP1) targeting contrast-enhanced MRI as a novel strategy for epilepsy imaging Open
In this article of EBioMedicine [[1]Wang C. Zhang J. Song S. Li Z. Yin S. Duan W. Wei Z. Qi M. Sun W. Zhang L. Chen L. Gao X. Mao Y. Wang H. Chen L. Li C. Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-relate…
View article: Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI
Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI Open
The kidney plays a major role in maintaining body pH homeostasis. Renal pH, in particular, changes immediately following injuries such as intoxication and ischemia, making pH an early biomarker for kidney injury before the symptom onset an…
View article: Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST) MRI: Experimental Protocol
Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST) MRI: Experimental Protocol Open
Chemical exchange saturation transfer (CEST) is recognized as one of the premier methods for measuring pH with this environmental variable expected to be an excellent biomarker for kidney diseases. Here we describe step-by-step CEST MRI ex…