Zoran Popović
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View article: Contemporary Review of Subaortic Stenosis Characteristics, Multi-modality Imaging and Management
Contemporary Review of Subaortic Stenosis Characteristics, Multi-modality Imaging and Management Open
Purpose of Review This review aims to provide a comprehensive contemporary overview regarding the clinical perspectives, multi-modality imaging evaluation, treatments and outcomes of subaortic stenosis (SAS). Recent Findings SAS remains an…
View article: Characteristics and long-term outcomes of asymptomatic patients with hypertrophic cardiomyopathy
Characteristics and long-term outcomes of asymptomatic patients with hypertrophic cardiomyopathy Open
Background While patients with hypertrophic cardiomyopathy (HCM) often develop symptoms due to dynamic left ventricular outflow tract obstruction (LVOTO), diastolic dysfunction, arrhythmias and ischemia, many patients remain asymptomatic f…
View article: Real‐World Observations in Patients With Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Evidence of Favorable Disease Modification
Real‐World Observations in Patients With Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Evidence of Favorable Disease Modification Open
Background Mavacamten is commercially approved for use in symptomatic patients with obstructive hypertrophic cardiomyopathy. This study evaluated its real‐world impact on symptoms, echocardiographic changes, and the need for septal reducti…
View article: Real-World Artificial Intelligence–Based Electrocardiographic Analysis to Diagnose Hypertrophic Cardiomyopathy
Real-World Artificial Intelligence–Based Electrocardiographic Analysis to Diagnose Hypertrophic Cardiomyopathy Open
Prospective real-world application of the AI-ECG algorithm to detect HCM was associated with a high degree of accuracy, varying with the chosen probability threshold. It also enabled the identification of 5% of patients with no prior HCM d…
View article: Calcium and vitamin D supplementation impact on survival in patients with moderate concomitant aortic and mitral valve disease
Calcium and vitamin D supplementation impact on survival in patients with moderate concomitant aortic and mitral valve disease Open
Calcium supplement intake, with or without vitamin D supplementation, has risen amongst the older population, who are more likely to have deficiencies. Our aim was to investigate how the supplementation of calcium and vitamin D is associat…
View article: Reference Ranges of Left Ventricular Global Longitudinal Strain by Contemporary Vendor‐Neutral Echocardiography Software in Healthy Subjects
Reference Ranges of Left Ventricular Global Longitudinal Strain by Contemporary Vendor‐Neutral Echocardiography Software in Healthy Subjects Open
Background Left ventricular global longitudinal strain (LVGLS) by speckle‐tracking transthoracic echocardiography (TTE) is an established measure of left ventricular systolic function with many clinical applications. Strain software has ev…
View article: Left atrial strain by vendor-neutral echocardiography software in healthy subjects: vendor comparisons and associated factors
Left atrial strain by vendor-neutral echocardiography software in healthy subjects: vendor comparisons and associated factors Open
Aims Left atrial strains [reservoir (LASr), conduit (LAScd), and contractile (LASct)] are increasingly utilized, primarily in the areas of heart failure and valvulopathy. Commercially available software to measure strain are marketed as im…
View article: Sex differences in cardiac remodelling in ischaemic cardiomyopathy and functional mitral regurgitation: impact on prognosis
Sex differences in cardiac remodelling in ischaemic cardiomyopathy and functional mitral regurgitation: impact on prognosis Open
Aims Sex differences in prognosis of functional mitral regurgitation (FMR) associated with ischaemic cardiomyopathy (ICM) demonstrate the need to identify sex differences in cardiac remodelling. This study aimed to characterize sex differe…
View article: Echocardiographic Changes Following Surgical Myectomy in Severely Symptomatic Obstructive Hypertrophic Cardiomyopathy: Insights From the SPIRIT‐HCM Study
Echocardiographic Changes Following Surgical Myectomy in Severely Symptomatic Obstructive Hypertrophic Cardiomyopathy: Insights From the SPIRIT‐HCM Study Open
Background In obstructive hypertrophic cardiomyopathy, myectomy improves symptoms, quality of life, and left ventricular (LV) outflow tract gradients. We prospectively evaluated the temporal changes in various echo parameters after myectom…
View article: Contemporary Clinical Characteristics, Imaging, Management, and Surgical and Nonsurgical Outcomes of Adult Patients With Subaortic Stenosis
Contemporary Clinical Characteristics, Imaging, Management, and Surgical and Nonsurgical Outcomes of Adult Patients With Subaortic Stenosis Open
Background Subaortic stenosis (SAS) is characterized by a fibromuscular membrane located just below the aortic valve, causing fixed outflow tract obstruction. There is a paucity of studies evaluating this condition. This cohort study revie…
View article: Artificial intelligence machine learning based evaluation of elevated left ventricular end-diastolic pressure: a Cleveland Clinic cohort study
Artificial intelligence machine learning based evaluation of elevated left ventricular end-diastolic pressure: a Cleveland Clinic cohort study Open
Our study shows ML approaches can robustly predict elevated LVEDP and tau. ML may assist in the clinical interpretation of echocardiographic data.
View article: Real-world experience with mavacamten in obstructive hypertrophic cardiomyopathy: observations from a tertiary care center
Real-world experience with mavacamten in obstructive hypertrophic cardiomyopathy: observations from a tertiary care center Open
Background In symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patients, mavacamten is commercially approved to help improve left ventricular (LV) outflow tract (LVOT) gradients, symptoms, and reduce eligibility for septal reduct…
View article: Diastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity
Diastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity Open
Diastolic dysfunction plays a major role in precipitating congestive heart failure in patients with hypertrophic cardiomyopathy (HCM). In many such patients, symptoms are unmasked only during exercise because left ventricular (LV) filling …
View article: Mavacamten-Associated Temporal Changes in Left Atrial Function in Obstructive HCM
Mavacamten-Associated Temporal Changes in Left Atrial Function in Obstructive HCM Open
In VALOR-HCM, mavacamten resulted in an improvement in LAVI and LA strain at week 56, suggesting sustained favorable LA remodeling and improved function, except in the atrial fibrillation subgroup. Whether the advantageous LA remodeling as…
View article: Serial Changes in Ventricular Strain in Symptomatic Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Insights From the VALOR-HCM Trial
Serial Changes in Ventricular Strain in Symptomatic Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Insights From the VALOR-HCM Trial Open
BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy, VALOR-HCM (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction T…