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P-1212. Enterovirus D68 (EV-D68) Incidence and Spectrum of Illness among Children 0-2 years in a U.S. Community-based Birth Cohort in Cincinnati, OH during 2017-2020 Open
Background The community burden and epidemiology of non-medically attended enterovirus-D68 (EV-D68) is unknown, as prior studies focus on EV-D68-associated asthma exacerbation, pneumonia, or acute flaccid myelitis (AFM) which occurs bienni…
View article: P-2358. Viral etiologies of bronchiolitis, pneumonia, and croup in children less than 5 years old, New Vaccine Surveillance Network, 2016-2022
P-2358. Viral etiologies of bronchiolitis, pneumonia, and croup in children less than 5 years old, New Vaccine Surveillance Network, 2016-2022 Open
Background Acute respiratory illness (ARI) is a leading cause of medically attended visits among children. A multi-season, multicenter, prospective evaluation of viral etiologies for different ARI syndromes is lacking. We describe the epid…
View article: Temporal Association Between Respiratory Viruses and Invasive Streptococcal Disease
Temporal Association Between Respiratory Viruses and Invasive Streptococcal Disease Open
BACKGROUND AND OBJECTIVES The temporal association between different noninfluenza respiratory viruses and invasive streptococcal disease is poorly understood. We sought to investigate the temporal association between invasive group A strep…
Overcoming Challenges for Non-US International Medical Graduates in Pediatric Infectious Diseases Open
International medical graduates (IMGs) in pediatric infectious diseases face unique and complex challenges related to their immigration status. This Perspective provides a review of challenges impacting non-US IMG trainees and early-career…
View article: Endemic Coronavirus Infections are Associated with Strong Homotypic Immunity in a US Cohort of Children from Birth to 4 Years
Endemic Coronavirus Infections are Associated with Strong Homotypic Immunity in a US Cohort of Children from Birth to 4 Years Open
Background The endemic coronaviruses OC43, HKU1, NL63, and 229E cause cold-like symptoms and are related to SARS-CoV-2, but their natural histories are poorly understood. In a cohort of children followed from birth to 4 years, we documente…
Factors Associated With Prolonged Respiratory Virus Detection From Polymerase Chain Reaction of Nasal Specimens Collected Longitudinally in Healthy Children in a US Birth Cohort Open
Background Respiratory viral shedding is incompletely characterized by existing studies due to the lack of longitudinal nasal sampling and limited inclusion of healthy/asymptomatic children. We describe characteristics associated with prol…
2622. Recent or concurrent rhino/enterovirus infection with respiratory syncytial virus associated with decreased symptoms and medical care use in healthy children, PREVAIL, 2017–2020 Open
Background Respiratory syncytial virus (RSV) infections are common in children, resulting in thousands of hospitalizations each year. Viral coinfections are frequently detected during RSV infection, but the effect of these coinfections is …
1702. Disseminated Candidiasis after Candidemia: Epidemiology, Diagnostic Evaluation, and Risk Factors Open
Background In patients with candidemia, evaluation for disseminated disease with ophthalmological exam and diagnostic imaging is recommended but not standardized. This study sought to describe practice patterns in the diagnostic evaluation…
View article: 1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years
1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years Open
Background Endemic coronaviruses (“CoVs”) OC43, HKU1, NL63 and 229E are “common cold viruses” related to SARS-CoV-2, but their natural histories are poorly understood. We documented endemic CoV infections in a prospective cohort of US infa…
View article: ICE volume 44 issue 8 Cover and Front matter
ICE volume 44 issue 8 Cover and Front matter Open
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Burden of Respiratory Viruses in Children Less Than 2 Years Old in a Community-based Longitudinal US Birth Cohort Open
Background Respiratory viral infections are a major cause of morbidity and hospitalization in young children. Nevertheless, the population burden of respiratory viral infections, especially asymptomatic cases, is not known due to the lack …
Monoclonal Antibodies for COVID-19 in Children: Case Series Should be Just the Start Open
Two new articles describe the use and implementation of monoclonal antibodies to treat COVID-19 in children. While these studies provide valuable guidance for pediatric clinicians, more studies of monoclonal antibodies and other COVID-19 t…
95. Prolonged respiratory viral infection associated with presence of coinfections in an urban birth cohort Open
Background Prolonged infection by respiratory viruses has been reported, especially in hospitalized or immunocompromised children. However, little is known of factors contributing to prolonged respiratory viral infection, particularly in a…
92. Incidence of <i>Adenovirus</i> Respiratory Infection and Coinfection in a Longitudinal Birth Cohort Open
Background Adenoviruses (AdVs) are a common cause of acute respiratory illness (ARI) in children and are often detected with other viruses (coinfection). However, the community incidence of AdV infections is poorly understood due to a lack…
View article: Tocilizumab for Treatment of Children and Young Adults With Severe Acute COVID-19: Experience at a Quaternary-care Children’s Hospital
Tocilizumab for Treatment of Children and Young Adults With Severe Acute COVID-19: Experience at a Quaternary-care Children’s Hospital Open
We describe the clinical characteristics and outcomes of 16 children and young adults with severe acute COVID-19 who were treated with tocilizumab. Patients who were discharged by day 28 were more likely to be treated with tocilizumab earl…
View article: The Coronavirus Disease 2019 Pandemic Unmasked the Challenges Faced by Early-Stage Faculty in Infectious Diseases: A Call to Action
The Coronavirus Disease 2019 Pandemic Unmasked the Challenges Faced by Early-Stage Faculty in Infectious Diseases: A Call to Action Open
The coronavirus disease 2019 (COVID-19) pandemic and associated increase in family care responsibilities resulted in unsustainable personal and professional workloads for infectious diseases (ID) faculty on the front lines. This was especi…
An outbreak of <i>Burkholderia contaminans</i> at a quaternary children’s hospital linked to equipment reprocessing Open
Burkholderia cepacia complex (BCC) has been increasingly implicated in local and multistate outbreaks in both adult and pediatric healthcare settings. However, a lack of source identification may be common for BCC outbreak investigations. …
Learnings from a Cutibacterium acnes pseudo-outbreak in pediatric neurosurgical patients Open
Background: Cutibacterium acnes is normal skin flora as well as a common culture contaminant. It can cause infections in the setting of sterile implants, although clinical presentations can be subtle. Differentiating true infection from sa…
Invasive Malassezia pachydermatis Infection in an 8-Year-Old Child on Lipid Parenteral Nutrition Open
Invasive disease due to Malassezia pachydermatis infection is uncommon but increasingly recognized in children, especially neonates on parenteral nutrition or immunocompromised children. We describe a case of Malassezia pachydermatis funge…
Evaluating Perception of Child Health and Safety Needs in a Community Through the Perspective of Caregivers and Physicians Open
Objective: To identify and compare child health and safety concerns in the community from the perspective of physicians and caregivers in Louisville. Design: We administered surveys to physicians and caregivers who were asked to list, via …
Healthcare Barriers for Congolese Refugee Children in Louisville, KY: Parental Perception and Narratives through Focus Group Discussions Open
Background: There are up to 3500 refugees who resettle in Kentucky annually with 66% of refugee children originating from the Democratic Republic of the Congo. Little is known about the barriers to healthcare perceived by Congolese parents…
A case report of three children with secondary hypertension caused by Liddle syndrome Open
Due to its variable penetrance, Liddle syndrome can have varying severity of blood pressure and electrolyte disturbances. Prompt recognition of Liddle syndrome is important to prevent cardiovascular complications from uncontrolled hyperten…
Making stillbirths visible: a systematic review of globally reported causes of stillbirth Open
Background Stillbirth is a global health problem. The World Health Organization ( WHO ) application of the International Classification of Diseases for perinatal mortality ( ICD ‐ PM ) aims to improve data on stillbirth to enable preventio…
Left ventricle and systemic air embolism after percutaneous lung biopsy Open
Although systemic arterial air embolism remains a rare complication of percutaneous lung biopsies, recognition prevents potential mortality which can develop due to neurological and cardiac complications. Close vigilance in the intensive c…