Zach Fyke
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View article: Neuroinflammation in Olfactory Circuits Underlies Odor Hypersensitivity in a Rodent Model of Depression
Neuroinflammation in Olfactory Circuits Underlies Odor Hypersensitivity in a Rodent Model of Depression Open
Depression can affect quality of life in several ways, including reduced concentration, motivation, and energy. Olfactory anhedonia in depressed patients results in a decreased attraction to pleasant smells and increased aversion to unplea…
View article: Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding
Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding Open
Sensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfactory system, where olfactory sensory n…
View article: Amplification of olfactory transduction currents implements sparse stimulus encoding
Amplification of olfactory transduction currents implements sparse stimulus encoding Open
Sensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfactory system, where OSNs are highly sen…
View article: Shaping smell: chloride currents dictate the kinetics of olfactory transduction
Shaping smell: chloride currents dictate the kinetics of olfactory transduction Open
The sensory modalities are anatomically, biochemically and physiologically organized to detect and perceive vanishingly small quantities of environmental stimulus energies. The visual system's sensitivity is sufficient to detect single pho…
View article: Reduction of neuroinflammation and seizures in a mouse model of CLN1 batten disease using the small molecule enzyme mimetic, N-Tert-butyl hydroxylamine
Reduction of neuroinflammation and seizures in a mouse model of CLN1 batten disease using the small molecule enzyme mimetic, N-Tert-butyl hydroxylamine Open
Infantile neuronal ceroid lipofuscinosis (CLN1 Batten Disease) is a devastating pediatric lysosomal storage disease caused by pathogenic variants in the CLN1 gene, which encodes the depalmitoylation enzyme, palmitoyl-protein thioesterase 1…
View article: Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis
Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis Open
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), …
View article: Loss of Depalmitoylation Exaggerates Synaptic Upscaling and Leads to Neuroinflammation in a Lysosomal Storage Disease
Loss of Depalmitoylation Exaggerates Synaptic Upscaling and Leads to Neuroinflammation in a Lysosomal Storage Disease Open
Summary Palmitoylation and depalmitoylation are the dichotomic processes of lipid modification regulating protein trafficking, recycling, and degradation, thereby controlling proteostasis. Despite our understanding of palmitoylation, depal…