Zachary A. Bornholdt
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View article: Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus
Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus Open
Crimean-Congo hemorrhagic fever virus (CCHFV) is an enveloped, negative-sense RNA virus that is spread by ticks across Europe, Africa, and Asia and causes a lethal disease in humans (~30%–40% case fatality). There are currently no approved…
View article: Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies
Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies Open
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance. Their activities c…
View article: Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a Pan-Ebolavirus Immunotherapeutic
Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a Pan-Ebolavirus Immunotherapeutic Open
Intravenous (IV) administration of antiviral monoclonal antibodies (mAbs) can be challenging, particularly during an ongoing epidemic, due to the considerable resources required for performing infusions. An ebolavirus therapeutic administe…
View article: Combination therapy with remdesivir and monoclonal antibodies protects nonhuman primates against advanced Sudan virus disease
Combination therapy with remdesivir and monoclonal antibodies protects nonhuman primates against advanced Sudan virus disease Open
A major challenge in managing acute viral infections is ameliorating disease when treatment is delayed. Previously, we reported the success of a 2-pronged mAb and antiviral remdesivir therapeutic approach to treat advanced illness in rhesu…
View article: Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses
Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses Open
The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus (ANDV) and Sin Nombre virus, cause a distinct zoonotic disease, han…
View article: Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies
Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies Open
View article: Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies
Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies Open
A block to viral cell entry Crimean-Congo hemorrhagic fever virus is a tickborne virus that can cause severe disease and even death in humans. Disease occurrence is linked to the geographic range of the tick vector, and climate change may …
View article: Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a pan-Ebolavirus Immunotherapeutic
Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a pan-Ebolavirus Immunotherapeutic Open
Intravenous administration (IV) of antiviral monoclonal antibodies (mAbs) is challenging due to limited resources for performing infusions during an ongoing epidemic. An ebolavirus therapeutic administered via intramuscular (IM) injection …
View article: Characterization of Bombali Virus, a New Bat Filovirus
Characterization of Bombali Virus, a New Bat Filovirus Open
View article: Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced Antibodies
Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced Antibodies Open
Summary The resurgence of yellow fever in South America has prompted mitigation through vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a virulent African isolate, and their capacity to indu…
View article: Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein
Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein Open
View article: Determining the Patchwork Lattice of Ebola and Marburg Virus Matrix Layers Using Cryo-Electron Tomography
Determining the Patchwork Lattice of Ebola and Marburg Virus Matrix Layers Using Cryo-Electron Tomography Open
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View article: Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever Open
View article: Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins Open
View article: Combination therapy protects macaques against advanced Marburg virus disease
Combination therapy protects macaques against advanced Marburg virus disease Open
Monoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae ), and more recently, SARS-CoV-2. One of…
View article: Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody
Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody Open
Significance Despite the relatively high disease burden of arenaviruses in South America and Africa, there are currently no Food and Drug Administration-approved drugs for use in preventing or treating any arenavirus infection. Currently, …
View article: Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers
Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers Open
Filoviruses such as Ebola and Marburg virus bud from the host membrane as enveloped virions. This process is achieved by the matrix protein VP40. When expressed alone, VP40 induces budding of filamentous virus-like particles, suggesting th…
View article: Author response: Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers
Author response: Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers Open
View article: Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment
Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment Open
View article: Neutralizing Antibodies against Crimean–Congo Hemorrhagic Fever Virus Derived from a Human Survivor
Neutralizing Antibodies against Crimean–Congo Hemorrhagic Fever Virus Derived from a Human Survivor Open
Crimean–Congo hemorrhagic fever virus (CCHFV) is an arbovirus belonging to the Nairoviridae family. The virus, as well as ticks of the Hyalomma genus, which serve as its reservoir host, are found in parts of Africa, we…
View article: Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers
Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers Open
A key step in the life cycle of enveloped viruses is the budding of nascent virions from the host membrane. In filoviruses such as Ebola and Marburg virus, this process is achieved by the matrix protein VP40. When expressed alone, VP40 ind…
View article: Prior vaccination with the rVSV-ZEBOV vaccine does not interfere with but improves the efficacy of postexposure antibody treatment in nonhuman primates exposed to Ebola virus
Prior vaccination with the rVSV-ZEBOV vaccine does not interfere with but improves the efficacy of postexposure antibody treatment in nonhuman primates exposed to Ebola virus Open
A replication-competent, vesicular stomatitis virus vaccine expressing the Ebola virus (EBOV) glycoprotein (GP) (rVSV-ZEBOV) was successfully used during the 2013-16 EBOV epidemic 1 . Additionally, chimeric and human monoclonal antibodies …
View article: Prior vaccination with the rVSV-ZEBOV vaccine does not interfere with but improves the efficacy of postexposure antibody treatment in nonhuman primates exposed to Ebola virus
Prior vaccination with the rVSV-ZEBOV vaccine does not interfere with but improves the efficacy of postexposure antibody treatment in nonhuman primates exposed to Ebola virus Open
A replication-competent, vesicular stomatitis virus vaccine expressing the Ebola virus (EBOV) glycoprotein (GP) (rVSV-ZEBOV) was successfully used during the 2013-16 EBOV epidemic 1 . Additionally, chimeric and human monoclonal antibodies …
View article: Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine
Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine Open
A comprehensive understanding of the development and evolution of human B cell responses induced by pathogen exposure will facilitate the design of next-generation vaccines. Here, we utilized a high-throughput single B cell cloning technol…
View article: Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin
Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin Open
View article: Development of an antibody cocktail for treatment of Sudan virus infection
Development of an antibody cocktail for treatment of Sudan virus infection Open
Significance Ebolaviruses pose a significant threat to the global community, particularly in areas of equatorial and West Africa. While Ebola virus has caused the greatest number of human cases, Sudan virus is responsible for numerous outb…
View article: Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38
Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38 Open
Crimean-Congo hemorrhagic fever virus (CCHFV) is a priority pathogen that poses a high risk to public health. Due to the high morbidity and mortality rates associated with CCHFV infection, there is an urgent need to develop medical counter…
View article: Structural Basis of Neutralization by Human Antibodies Targeting Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Gc
Structural Basis of Neutralization by Human Antibodies Targeting Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Gc Open
View article: A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry
A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry Open
Ebola virus is a medically relevant virus responsible for outbreaks of severe disease in western and central Africa, with mortality rates reaching as high as 90%. Despite considerable effort, there are currently no FDA-approved therapeutic…
View article: A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates
A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates Open