Zachary D. Tillett
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View article: Structural basis of isethionate transport by a TRAP transporter from a sulfate-reducing bacterium
Structural basis of isethionate transport by a TRAP transporter from a sulfate-reducing bacterium Open
Sulfate-reducing bacteria import organosulfur compounds from the environment for anaerobic respiration. They contribute to human disease and are problematic in industrial settings because they produce hydrogen sulfide. Here, we demonstrate…
View article: The trimeric structures of the extracellular domains of FAM171A1 and FAM171A2 neuronal proteins belong to a novel structural superfamily
The trimeric structures of the extracellular domains of FAM171A1 and FAM171A2 neuronal proteins belong to a novel structural superfamily Open
Cell surface molecules play fundamental roles in cell-cell communication, attraction, or repulsion, and when expressed in neurons they are often implicated in neurological disorders. FAM171 is a family of three type-I transmembrane domain …
View article: On the function of TRAP substrate-binding proteins: the isethionate-specific binding protein IseP
On the function of TRAP substrate-binding proteins: the isethionate-specific binding protein IseP Open
Bacteria evolve mechanisms to compete for limited resources and survive in new niches. Here we study the mechanism of isethionate import from the sulfate-reducing bacterium Oleidesulfovibrio alaskensis. The catabolism of isethionate by Des…
View article: On the function of TRAP substrate-binding proteins: Conformational variation of the sialic acid binding protein SiaP
On the function of TRAP substrate-binding proteins: Conformational variation of the sialic acid binding protein SiaP Open
View article: On the function of TRAP substrate-binding proteins: conformational variation of the sialic acid binding protein SiaP
On the function of TRAP substrate-binding proteins: conformational variation of the sialic acid binding protein SiaP Open
Tripartite ATP-independent periplasmic (TRAP) transporters are analogous to ABC transporters in that they use a substrate-binding proteins to scavenge metabolites ( e.g. , N -acetylneuraminate) and deliver them to the membrane components f…