Zachary J. Racenet
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View article: CD8+ T cell recall cytotoxicity during chronic treated HIV-1 infection is associated with limited reservoir size and activity
CD8+ T cell recall cytotoxicity during chronic treated HIV-1 infection is associated with limited reservoir size and activity Open
The combination of replication-competent HIV-1 proviral persistence and virus-specific immune dysfunction prevents virus clearance during antiretroviral therapy (ART), resulting in rebound viremia after treatment interruption. Functional i…
View article: Expanded Antigen‐Specific Elimination Assay to Measure Human CD8<sup>+</sup> T Cell Cytolytic Potential
Expanded Antigen‐Specific Elimination Assay to Measure Human CD8<sup>+</sup> T Cell Cytolytic Potential Open
Durable cellular immunity against pathogens is dependent upon a coordinated recall response to antigen by memory CD8 + T cells, involving their proliferation and the generation of secondary cytotoxic effector cells. Conventional assays mea…
View article: Cytolytic CD8 <sup>+</sup> T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes
Cytolytic CD8 <sup>+</sup> T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes Open
Follicular CD8 + T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers against lymphotropic infections and cancers, but the precise mechanisms by which these cells mediate immune control remain incompletely resolved. To a…