Zachary Oaks
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View article: Potassium-Hydroxide-Based Extraction of Nicotinamide Adenine Dinucleotides from Biological Samples Offers Accurate Assessment of Intracellular Redox Status
Potassium-Hydroxide-Based Extraction of Nicotinamide Adenine Dinucleotides from Biological Samples Offers Accurate Assessment of Intracellular Redox Status Open
The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) is a primary electron donor for both antioxidant enzymes, such as glutathione reductase, and pro-oxidant enzymes, such as NADPH oxidases that produce reactive oxygen s…
View article: Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation
Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation Open
Activation of the mechanistic target of rapamycin (mTOR) is a key metabolic checkpoint of pro-inflammatory T-cell development that contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), however,…
View article: Incident Learning in an Academic Radiation Oncology Practice during the COVID Era
Incident Learning in an Academic Radiation Oncology Practice during the COVID Era Open
View article: mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency
mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency Open
View article: Publisher Correction: Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis
Publisher Correction: Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis Open
View article: Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis
Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis Open
View article: Incident Learning in a Radiation Oncology Practice During the COVID Era
Incident Learning in a Radiation Oncology Practice During the COVID Era Open
View article: PIK3CA Mutations Are Not Correlated With Worse Disease-Free Survival in Early-Stage Cervical Cancer Treated With Surgery and Could be a Target for Overcoming Resistance to Chemoradiotherapy in Locally Advanced Cervical Cancer
PIK3CA Mutations Are Not Correlated With Worse Disease-Free Survival in Early-Stage Cervical Cancer Treated With Surgery and Could be a Target for Overcoming Resistance to Chemoradiotherapy in Locally Advanced Cervical Cancer Open
View article: Transaldolase haploinsufficiency in subjects with acetaminophen‐induced liver failure
Transaldolase haploinsufficiency in subjects with acetaminophen‐induced liver failure Open
Transaldolase (TAL) is an enzyme in the pentose phosphate pathway (PPP) that generates NADPH for protection against oxidative stress. While deficiency of other PPP enzymes, such as transketolase ( TKT ), are incompatible with mammalian cel…
View article: Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years
Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years Open
View article: Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus‐Prone Mice
Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus‐Prone Mice Open
Objective Antiphospholipid antibodies (aPL) constitute a diagnostic criterion of systemic lupus erythematosus (SLE), and aPL have been functionally linked to liver disease in patients with SLE. Since the mechanistic target of rapamycin (mT…
View article: Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus
Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus Open
View article: Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin
Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin Open