Explanipedia

Patient-derived Organoids and Neurospheres recapitulate salient features of primary tumor heterogeneity Open

Zachery Moore, Daniel V. Brown, Adam Valkovic, Montana Spiteri, Jeanine Pignatelli , et al. · 2025

Lay Summary Glioblastoma is a type of brain tumor that contains many different kinds of cells, which makes it difficult to treat and to study in the lab. The authors of this study wanted to compare two ways of growing tumor samples outside…

P01.06.B THERAPEUTIC REPURPOSING REVEALS NOVEL INTERVENTIONS FOR HETEROGENEOUS GLIOBLASTOMA Open

Zachery Moore, Adam Valkovic, Jeanine Pignatelli, A. Fakhri, Katharine J. Drummond , et al. · 2025

BACKGROUND The clinical management of glioblastoma (GBM) has remained unchanged since 2005, where the one-size-fits-all approach of surgical resection, radiotherapy, and chemotherapy was established. A critical factor in this therapeutic f…

Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial Open

Katharine J. Drummond, M A Spiteri, Sarah Cain, Jordan Jones, Sammy Shaya , et al. · 2025

Mutant isocitrate dehydrogenase (mIDH) inhibition significantly improves progression-free survival in patients with mIDH WHO grade 2 glioma; however, a large proportion of patients will progress, and mechanisms of adaptation to mIDH inhibi…

RAGE Knockout Mitigates Diet-Induced Obesity and Metabolic Disruption Open

I. Palmer, Genevieve Parker, Arthur Chiu, Colson G. Beus, E. Evans , et al. · 2025

Background/Objectives: The receptor for advanced glycation end products (RAGEs) has been implicated in obesity and metabolic dysfunction. However, its precise role in diet-induced obesity remains unclear. Methods: In this study, we investi…

TIRE-seq simplifies transcriptomics via integrated RNA capture and library preparation Open

Patrick O’Keeffe, Yasmin Nouri, Hui Shi Saw, Zachery Moore, Tracey M. Baldwin , et al. · 2025

RNA sequencing (RNA-seq) is widely used in biomedical research, advancing our understanding of gene expression across biological systems. Traditional methods require upstream RNA extraction from biological inputs, adding time and expense t…

Three-dimensional patient-derived models of glioblastoma retain intra-tumoral heterogeneity Open

Zachery Moore, Claire Storey, Daniel V. Brown, Adam Valkovic, Montana Spiteri , et al. · 2025

The intra- and inter-tumoral heterogeneity of glioblastoma represents a significant therapeutic challenge, as well as difficulty in generating reliable models for in vitro studies. Historical 2D adherent cell lines do not recapitulate this…

TIRE-seq: an Integrated Sample Extraction and Transcriptomics Workflow for High Throughput Perturbation Studies Open

Patrick O’Keeffe, Yasmin Nouri, Hui Shi Saw, Zachery Moore, Tracey M. Baldwin , et al. · 2024

RNA sequencing (RNA-seq) is widely used in biomedical research, advancing our understanding of gene expression across biological systems. Traditional methods require upstream RNA extraction from biological inputs, adding time and expense t…

Pharmacological inhibition of STING reduces neuroinflammation‐mediated damage post‐traumatic brain injury Open

Amelia L. Fryer, Amar Daud Iskandar Abdullah, Frank Mobilio, Andrew I. Jobling, Zachery Moore , et al. · 2024

Background and Purpose Traumatic brain injury (TBI) remains a major public health concern worldwide with unmet effective treatment. Stimulator of interferon genes (STING) and its downstream type‐I interferon (IFN) signalling are now apprec…

A risk-reward examination of sample multiplexing reagents for single cell RNA-Seq Open

Daniel V. Brown, Casey J. A. Anttila, Ling Ling, Patrick Gravé, Tracey M. Baldwin , et al. · 2024

Single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for understanding cellular heterogeneity and function. However the choice of sample multiplexing reagents can impact data quality and experimental outcomes. In this stud…

Matrix Selection for the Visualization of Small Molecules and Lipids in Brain Tumors Using Untargeted MALDI-TOF Mass Spectrometry Imaging Open

Tianyao Lu, Lutz Freytag, Vinod K. Narayana, Zachery Moore, Shannon J. Oliver , et al. · 2023

Matrix-assisted laser desorption/ionization mass spectrometry imaging allows for the study of metabolic activity in the tumor microenvironment of brain cancers. The detectable metabolites within these tumors are contingent upon the choice …

Matrix selection for the visualization of small molecules and lipids in brain tumors using untargeted MALDI-TOF mass spectrometry imaging Open

Tianyao Lu, Lutz Freytag, Vinod K. Narayana, Zachery Moore, Shannon J. Oliver , et al. · 2023

Matrix-assisted laser desorption/ionization mass spectrometry imaging allows the study of metabolic activity in the tumor microenvironment of brain cancers. The detectable metabolites within these tumors are contingent upon the choice of m…

Pharmacological inhibition of STING reduces neuroinflammation-mediated damage post-traumatic brain injury Open

Amelia L. Fryer, Amar Daud Iskandar Abdullah, Frank Mobilio, Zachery Moore, Gang Zheng , et al. · 2023

Background and Purpose: Traumatic brain injury (TBI) remains a major public health concern worldwide with unmet effective treatment. Stimulator of Interferon Genes (STING) protein and its downstream type-I Interferon (IFN) signaling are no…

A Risk-reward Examination of Sample Multiplexing Reagents for Single Cell RNA-Seq Open

Daniel V. Brown, Casey J. A. Anttila, Ling Ling, Patrick Gravé, Tracey M. Baldwin , et al. · 2023

Single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for understanding cellular heterogeneity and function. However the choice of sample multiplexing reagents can impact data quality and experimental outcomes. In this stud…

An altered glial phenotype in the NL3R451C mouse model of autism Open

Samantha M. Matta, Zachery Moore, Frederick R. Walker, Elisa L. Hill‐Yardin, Peter J. Crack · 2020

Abrogation of type-I interferon signalling alters the microglial response to Aβ1–42 Open

Zachery Moore, Frank Mobilio, Frederick R. Walker, Juliet M. Taylor, Peter J. Crack · 2020

The involvement of microglia in Alzheimer's disease: a new dog in the fight Open

Zachery Moore, Juliet M. Taylor, Peter J. Crack · 2018

First described clinically in 1906, Alzheimer's disease (AD) is the most common neurodegenerative disease and form of dementia worldwide. Despite its prevalence, only five therapies are currently approved for AD, all dealing with the sympt…

Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer’s disease Open

Juliet M. Taylor, Zachery Moore, Myles R. Minter, Peter J. Crack · 2017

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype Open

Myles R. Minter, Zachery Moore, Moses Zhang, Kate M. Brody, Nigel C. Jones , et al. · 2016

A neuro-inflammatory response is evident in Alzheimer's disease (AD), yet the precise mechanisms by which neuro-inflammation influences the progression of Alzheimer's disease (AD) remain poorly understood. Type-1 interferons (IFNs) are mas…

Additional file 2: Table S1. of Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype Open

Myles R. Minter, Zachery Moore, Moses Zhang, Kate M. Brody, Nigel C. Jones , et al. · 2016

Statistical table (See additional statistical table file). Statistical analysis information is displayed for all data displayed within the accompanying figures. Power values were determined post-hoc based upon population effect size, sampl…

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