Zack M. Strater
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View article: Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome
Macrocyclic Oxindole Peptide Epoxyketones─A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome Open
Peptide macrocycles have recently gained attention as protease inhibitors due to their metabolic stability and specificity. However, the development of peptide macrocycles with improved binding potency has so far been challenging. Here we …
View article: Methods for preparing formaldehyde from carbon dioxide
Methods for preparing formaldehyde from carbon dioxide Open
The present disclosure provides, inter alia, methods for preparing formaldehyde from carbon dioxide using bis(silyl)acetals, methods for incorporating carbon derived from carbon dioxide into a complex organic molecule derived from formalde…
View article: Electrophotocatalytic C–H Functionalization of Ethers with High Regioselectivity
Electrophotocatalytic C–H Functionalization of Ethers with High Regioselectivity Open
The highly regioselective electrophotocatalytic C-H functionalization of ethers is described. These reactions are catalyzed by a trisaminocyclopropenium (TAC) ion at mild electrochemical potential with visible light irradiation. Ethers und…
View article: Selective Conversion of Carbon Dioxide to Formaldehyde via a Bis(silyl)acetal: Incorporation of Isotopically Labeled C<sub>1</sub> Moieties Derived from Carbon Dioxide into Organic Molecules
Selective Conversion of Carbon Dioxide to Formaldehyde via a Bis(silyl)acetal: Incorporation of Isotopically Labeled C<sub>1</sub> Moieties Derived from Carbon Dioxide into Organic Molecules Open
The conversion of carbon dioxide to formaldehyde is a transformation that is of considerable significance in view of the fact that formaldehyde is a widely used chemical, but this conversion is challenging because CO2 is resistant to chemi…
View article: Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication
Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication Open
Visible‐light photocatalysis and electrocatalysis are two powerful strategies for the promotion of chemical reactions. Here, these two modalities are combined in an electrophotocatalytic oxidation platform. This chemistry employs a trisami…
View article: Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication
Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication Open
Visible‐light photocatalysis and electrocatalysis are two powerful strategies for the promotion of chemical reactions. Here, these two modalities are combined in an electrophotocatalytic oxidation platform. This chemistry employs a trisami…
View article: Oxidizable Ketones: Persistent Radical Cations from the Single‐Electron Oxidation of 2,3‐Diaminocyclopropenones.
Oxidizable Ketones: Persistent Radical Cations from the Single‐Electron Oxidation of 2,3‐Diaminocyclopropenones. Open
Single electron oxidation of 2,3‐diaminocyclopropenones is shown to give rise to stable diaminocyclopropenium oxyl (DACO) radical cations. Cyclic voltammetry reveals reversible oxidations in the range of +0.70–1.10 V (vs. SCE). Computation…
View article: Stable Cyclopropenium-Based Radicals
Stable Cyclopropenium-Based Radicals Open
Stable radicals have enjoyed widespread use in a variety of fields including synthetic chemistry, materials chemistry, energy storage, and biochemistry. This thesis outlines our investigations of cyclopropenium-based stable radicals and th…
View article: Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S Proteasome
Synthesis and Evaluation of Macrocyclic Peptide Aldehydes as Potent and Selective Inhibitors of the 20S Proteasome Open
This research explores the first design and synthesis of macrocyclic peptide aldehydes as potent inhibitors of the 20S proteasome. Two novel macrocyclic peptide aldehydes based on the ring-size of the macrocyclic natural product TMC-95 wer…