Zeena Salman
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View article: An Innovative Virtual Fellowship Leveraging Global and Regional Mentorship to Foster Pediatric Neuro-Oncologists in Low/Middle-Income Countries
An Innovative Virtual Fellowship Leveraging Global and Regional Mentorship to Foster Pediatric Neuro-Oncologists in Low/Middle-Income Countries Open
Background Most children with central nervous system (CNS) tumors reside in low- and middle-income countries (LMICs), with limited availability of trained pediatric neuro-oncologists. Methods Using a series of structured interviews of phys…
View article: Inflammatory Biomarkers Predicting Osteoporosis in Autoimmune and Chronic Inflammatory Diseases: A Systematic Review
Inflammatory Biomarkers Predicting Osteoporosis in Autoimmune and Chronic Inflammatory Diseases: A Systematic Review Open
Chronic autoimmune and inflammatory diseases (e.g. rheumatoid arthritis [RA], systemic lupus erythematosus [SLE], inflammatory bowel disease [IBD], ankylosing spondylitis [AS], psoriasis) are frequently accompanied by systemic bone loss an…
View article: Correction: Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Correction: Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
View article: Evaluation of Temperature Distribution on Human Skin During Philaser Tattoo Removal
Evaluation of Temperature Distribution on Human Skin During Philaser Tattoo Removal Open
Many difficulties were recorded during laser-assisted tattoo removal. But most of them remain unknown. The recent literatures on laser tattoo removal focuses more on removal methods and systems than on side effects, such as temperature inc…
View article: From Pancreas to Heart: Takotsubo Cardiomyopathy Following Acute Pancreatitis
From Pancreas to Heart: Takotsubo Cardiomyopathy Following Acute Pancreatitis Open
In cases of severe acute pancreatitis, clinicians must maintain a vigilant approach toward potential cardiac complications, particularly when confronted with unexplained electrocardiographic changes or modest elevations in cardiac biomarke…
View article: Silent Valves, Painful Abdomen: Missed Infective Endocarditis Revealed by Splenic Abscess
Silent Valves, Painful Abdomen: Missed Infective Endocarditis Revealed by Splenic Abscess Open
Exclusion of infective endocarditis (IE) based solely on the absence of an audible murmur or traditional predisposing risk factors is a critical diagnostic error, as a significant proportion of patients lack these features at presentation.…
View article: Hybrid Cooling and Smart Automation in Atmospheric Water Generation: A Sustainable Solution for Water-Scarce Regions
Hybrid Cooling and Smart Automation in Atmospheric Water Generation: A Sustainable Solution for Water-Scarce Regions Open
Water shortage, intensified by climate change and population expansion, demands water extraction methods. This project seeks to design and assess an atmospheric water generator (AWG) incorporating a vapor compression system with evaporativ…
View article: Supplementary Table S3 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S3 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S3 shows PK and/or PD data of RMC-6236 in subcutaneous xenograft tumors, intracranially implanted xenograft tumors, normal brain from naüve mice, and ear skin and colon from xenograft tumor bearing mice.
View article: Supplementary Table S8 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S8 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S8 shows all parameter estimates for PK/Efficacy and PK/PD modeling.
View article: Supplementary Table S4 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S4 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S4 shows % mean tumor volume change, % mean body weight change of RMC-6236 treatment group on mRECIST response calling date; and PPIA mRNA expression levels of each xenograft model in RMC-6236 mouse clinical trial.
View article: Supplementary Table S9 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S9 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S9 shows datasets used for PK/Efficacy and PK/PD modeling.
View article: Supplementary Table S7 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S7 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S7 showes final processing and refinement statistics used for RMC-6236 Crystallography data collection and refinement.
View article: Supplementary Table S1 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S1 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S1 shows information on the PRISM cell set comprised of 845 cell lines representing more than 45 lineages.
View article: Figure 4 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Figure 4 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Translating RMC-6236 activity in NSCLC. A, Efficacy of RMC-6236 on KrasG12C, KrasG12D, KrasG12V, KrasG12A, KrasG13D, or KrasQ61H
View article: Figure 5 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Figure 5 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Effects of RMC-6236 mediated pharmacologic modulation of RAS pathway signaling in tumor-bearing mice. A, PK/PD relationship between RMC-6236 concentration and inhibition of DUSP6 expression in Capan-2 (EC50 = 90 nm…
View article: Figure 7 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Figure 7 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Activity of RMC-6236 in pancreatic and lung cancer patients. A, Pretreatment and 12-week (post cycle 4) scans of a heavily pretreated patient with a KRASG12D mutation-positive PDAC indicating a complete response of…
View article: Figure 3 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Figure 3 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Broad-spectrum antitumor activity of RMC-6236 in preclinical models of RAS-addicted cancers. A–C, Tumor response waterfall plots of KRASG12X NSCLC (A), PDAC (B), and colorectal cancer (C) xenog…
View article: Figure 2 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Figure 2 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
RMC-6236 inhibits RAS signaling and tumor growth and drives tumor regressions in vivo.A, Blood and tumor PK profiles of RMC-6236 in Capan-2 (KRASG12V/WT, PDAC) xenograft tumor-bearing BALB/c nude mice. Tumor…
View article: Figure 1 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Figure 1 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
RMC-6236 is a potent noncovalent inhibitor of the GTP-bound state of multiple RAS variants in vitro. A, Chemical structure of RMC-6236. B, Biochemical potency of RMC-6236 for wild-type KRAS, NRAS, HRAS, and several onc…
View article: Figure 6 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Figure 6 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
PK/PD/Efficacy modeling to predict clinically active dose range. A, Comparison of observed and predicted tumor growth data at multiple dose levels of RMC-6236 in the NCI-H441 xenograft tumor model. Tumor growth was predicted using t…
View article: Supplementary Table S5 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S5 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S5 shows time to tumor doubling of individual animals in RMC-6236 mouse clinical trial.
View article: Supplementary Table S6 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S6 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S6 shows PK/PD data used to derive PK/PD relationship curves in Fig. 5 and Fig. S5.
View article: Supplementary Method from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Method from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
RMC-6236 synthetic route and detailed PK/PD/Efficacy Modeling method
View article: Supplementary Figure S1-S6 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Figure S1-S6 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Figure 1 shows RMC-6236 crystal structure in tri-complex, as well as biophysical and cellular potencies of RMC-6236 by genotype.Supplementary Figure 2 shows RMC-6236 demonstrates dose-dependent anti-tumor activities at tolera…
View article: Supplementary Table S2 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers
Supplementary Table S2 from Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers Open
Supplementary Table S2 shows cell panel screening data with a panel of 78 cancer cell lines harboring mutant and wild-type RAS selected for screening at Crown Bioscience.
View article: Design of Arduino-Based Low-Cost, Specific Heat Capacity Measurement Device for Solids
Design of Arduino-Based Low-Cost, Specific Heat Capacity Measurement Device for Solids Open
Digital simulations and modelling tools have proven beneficial in researching specific heat capacity. Computational thermodynamics allows scientists to anticipate materials' thermal behaviour, reducing the need for significant experiments.…
View article: Restoring health and hope to displaced Gaza children with malignant disease at a cancer centre in Jordan
Restoring health and hope to displaced Gaza children with malignant disease at a cancer centre in Jordan Open
Background: Gaza children with cancer have faced critical delays in diagnosis and treatment due to the conflict, leading to late-stage presentation. Aim: To assess the impact of disruptions on treatment outcome for Gaza children with cance…
View article: Trends in childhood cancer: Incidence and survival analysis over 45 years of SEER data
Trends in childhood cancer: Incidence and survival analysis over 45 years of SEER data Open
Background The SEER Registry contains U.S. cancer statistics. To assess trends in incidence and survival and the impact of demographic factors among pediatric patients with cancer, we assessed nearly 5 decades (1975–2019) of data. Methods …
View article: Real-world experience in dealing with children with suspected CNS tumors at the largest public-sector center in Pakistan
Real-world experience in dealing with children with suspected CNS tumors at the largest public-sector center in Pakistan Open
View article: A manifesto on improving cancer care in conflict-impacted populations
A manifesto on improving cancer care in conflict-impacted populations Open