Zahra Sahraei
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View article: Comparison of Pharmacokinetic/Pharmacodynamic Parameters and Clinical Outcomes of Vancomycin Administered in Two Different Dosage Regimens in Patients with Acute Kidney Injury
Comparison of Pharmacokinetic/Pharmacodynamic Parameters and Clinical Outcomes of Vancomycin Administered in Two Different Dosage Regimens in Patients with Acute Kidney Injury Open
Background: Vancomycin is commonly used in intensive care units (ICUs), but its optimal dosage in patients with acute kidney injury (AKI) remains uncertain. This study aimed to evaluate vancomycin's pharmacokinetic and pharmacodynamic (PK/…
View article: The Efficacy of High-Dose Pulse Therapy vs. Low-Dose Intravenous Methylprednisolone on Severe to Critical COVID-19 Clinical Outcomes: A Randomized Clinical Trial
The Efficacy of High-Dose Pulse Therapy vs. Low-Dose Intravenous Methylprednisolone on Severe to Critical COVID-19 Clinical Outcomes: A Randomized Clinical Trial Open
Background: It remains unclear which formulation of the corticosteroid regimen has the optimum efficacies on COVID-19 pneumonia. Objectives: The aim of this study was to compare the clinical outcomes of 2 different regimens in the treatmen…
View article: Evaluation of vancomycin pharmacokinetics in patients with augmented renal clearances: A randomized clinical trial
Evaluation of vancomycin pharmacokinetics in patients with augmented renal clearances: A randomized clinical trial Open
Purpose: Vancomycin is a narrow therapeutic window glycopeptide antibiotic that acts against Gram-positive bacteria. As it is renally eliminated, therapeutic drug monitoring is recommended for vancomycin, especially in case of kidney funct…
View article: The efficacy of high-dose pulse-therapy versus low-dose intravenous methylprednisolone on severe to critical COVID-19 clinical outcomes: A randomized clinical trial study
The efficacy of high-dose pulse-therapy versus low-dose intravenous methylprednisolone on severe to critical COVID-19 clinical outcomes: A randomized clinical trial study Open
Objectives It remains unclear which formulation of corticosteroid regimen has the optimum efficacies on COVID-19 pneumonia. Herein we evaluated two regimens including methylprednisolone at a dose of 1 mg/kg every 12 hours (low-dose group) …
View article: Datura poisoning in a family: Case series and literature review
Datura poisoning in a family: Case series and literature review Open
Datura spp. is a potentially poisonous plant that is widely spread and is simply accessible, which can yield poisoning with a central and peripheral anticholinergic effect. We reported cases of family poisoning caused by the herbal tea wit…
View article: Serotonin syndrome due to concomitant use of linezolid and methadone
Serotonin syndrome due to concomitant use of linezolid and methadone Open
We present a case of serotonin syndrome due to administration of linezolid in a patient with methadone addiction. This challenging entity is potentially life threatening but proper education and awareness about serotonin syndrome will impr…
View article: Study of the Effects of N-acetylcysteine on Inflammatory Biomarkers and Disease Activity Score in Patients with Rheumatoid Arthritis
Study of the Effects of N-acetylcysteine on Inflammatory Biomarkers and Disease Activity Score in Patients with Rheumatoid Arthritis Open
Rheumatoid arthritis (RA) is considered as an autoimmune-related condition in which the overproduction of pro-inflammatory cytokines leads to an inflammatory cascade. N-acetylcysteine (NAC) is a potent anti-inflammatory and anti-oxidant ag…
View article: Early Graft Function in Deceased Donor Renal Recipients: Role of N-Acetylcysteine.
Early Graft Function in Deceased Donor Renal Recipients: Role of N-Acetylcysteine. Open
Reduced graft function (RGF) in donor renal transplant recipients is caused by oxidative damage due to extensive ischemia-reperfusion (I/R) injury during transplantation. Neutrophil gelatinase-associated lipocalin (NGAL) is a promising bio…
View article: Factors Affecting Child Labor in Iran: A Systematic Review
Factors Affecting Child Labor in Iran: A Systematic Review Open
Background For decades, child labor has been an important global issue associated with inadequate educational opportunities, poverty and gender inequality. In order to make effective policies to…
View article: Cutaneous Necrosis after the Injection of Sodium Stibogluconate for the Treatment of Cutaneous Leishmaniasis: A Rare Case Report
Cutaneous Necrosis after the Injection of Sodium Stibogluconate for the Treatment of Cutaneous Leishmaniasis: A Rare Case Report Open
A 32-year-old man was diagnosed with cutaneous leishmaniasis, and intradermal Sodium Stibogluconate was injected for him. After two days, the injection site became erythematous, and a progressive necrotizing lesion appeared; hence, the pat…
View article: Lidocaine as a Pain Reliever in Pharmaceutical Cocktails: A Serious Warning for Community Pharmacists
Lidocaine as a Pain Reliever in Pharmaceutical Cocktails: A Serious Warning for Community Pharmacists Open
Lidokain, sınıf 1-B antiaritmik ajanlara aittir ve öncelikle ventriküler aritmi tedavisinde kullanılır.Bu ajan ayrıca, aftöz stomatit ve dispepsi gibi durumlar için ağrı kesici olarak farmasötik kokteyllerde kullanılır
View article: Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran.
Is a Low Incidence Rate of Ventilation Associated Pneumonia Associated with Lower Mortality? a Descriptive Longitudinal Study in Iran. Open
According to the results, strategies to prevent mortality by reducing the duration of ventilation and ICU length of stay should be performed. Also, mandatory fees for the family and the healthcare system should be planned.
View article: Evaluation of Antibiotic Prophylaxis Administration at the General and Neuro-Surgery Ward of a Teaching Hospital in Tehran, Iran
Evaluation of Antibiotic Prophylaxis Administration at the General and Neuro-Surgery Ward of a Teaching Hospital in Tehran, Iran Open
View article: S100 B: A new concept in neurocritical care.
S100 B: A new concept in neurocritical care. Open
After brain injuries, concentrations of some brain markers such as S100B protein in serum and cerebrospinal fluid (CSF) are correlated with the severity and outcome of brain damage. To perform an updated review of S100B roles in human neur…
View article: Role of Clinical Pharmacists in Early Detection, Reporting and Prevention of Medication Errors in a Medical Ward
Role of Clinical Pharmacists in Early Detection, Reporting and Prevention of Medication Errors in a Medical Ward Open
Background: Drug utilization evaluation (DUE) is an effective process in order to identifying variability in drug use and subsequent application of effective interventions for improving patient outcomes. In this study, appropriate uses of …
View article: Effect of Vitamin D Supplementation on Procalcitonin as Prognostic Biomarker in Patients with Ventilator Associated Pneumonia Complicated with Vitamin D Deficiency.
Effect of Vitamin D Supplementation on Procalcitonin as Prognostic Biomarker in Patients with Ventilator Associated Pneumonia Complicated with Vitamin D Deficiency. Open
Ventilator-associated pneumonia (VAP) is a common and serious problem that develops after more than 48 h of mechanical ventilation. Improving the activity of immune system with vitamin D, and its consequent impact on prognostic biomarkers …
View article: Poly Pharmacy-Induced Long-QT Syndrome and Torsades de Pointes: A Case Report
Poly Pharmacy-Induced Long-QT Syndrome and Torsades de Pointes: A Case Report Open
Polypharmacy-induced QT prolongation is a possible hazardous adverse effect of several medication combinations. When QT prolongation leads to torsade de pointes, life-threatening or mortal outcomes can result. A 45-year-old man presented t…
View article: Study of The Effects of N-Acetylcysteine on Oxidative Stress Status of Patients on Maintenance-Hemodialysis Undergoing Cadaveric Kidney Transplantation.
Study of The Effects of N-Acetylcysteine on Oxidative Stress Status of Patients on Maintenance-Hemodialysis Undergoing Cadaveric Kidney Transplantation. Open
N-acetylcysteine (NAC) is a potent antioxidant that acts through regenerating glutathione stores and scavenging oxygen-free radicals. This study assesses the short-term effects of NAC in cadaveric kidney transplant (KT) recipients. A doubl…
View article: Deep Vein Thrombosis Prophylaxis Evaluation in Intensive Care Unit
Deep Vein Thrombosis Prophylaxis Evaluation in Intensive Care Unit Open
Background: One of the main causes of morbidity in hospitalized patients, and especially in the intensive care unit (ICU), is venous thromboembolism (VTE). The best way to deal with VTE is prophylaxis. Rational prophylaxis should be provid…