Zainab Adamji
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View article: Investigating the Role of Pikfyve in Modulating ER Functions/Dynamics and ER-Lysosome Contact Sites
Investigating the Role of Pikfyve in Modulating ER Functions/Dynamics and ER-Lysosome Contact Sites Open
Lysosomes are the major degradative organelle in the cell. Their degradative function is integrated with physiological functions like nutrient sensing, metabolic regulation, and cholesterol transport. The lipid kinase PIKfyve regulates lys…
View article: <i>Salmonella</i> actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner
<i>Salmonella</i> actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner Open
The transcription factor TFEB drives the expression of lysosomal, autophagic, and immune-responsive genes in response to LPS and phagocytosis. Interestingly, compounds that promote TFEB activity enhance bactericidal activity, while intrace…
View article: <i>Salmonella</i>actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner
<i>Salmonella</i>actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner Open
Summary The transcription factor TFEB drives expression of lysosomal, autophagic, and immune-responsive genes in response to LPS and phagocytosis. Interestingly, compounds that promote TFEB activity enhance bactericidal activity while intr…