Zainab Almoerifi
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View article: In Silico Characterization of Pathogenic ESR2 Coding and UTR Variants as Oncogenic Potential Biomarkers in Hormone-Dependent Cancers
In Silico Characterization of Pathogenic ESR2 Coding and UTR Variants as Oncogenic Potential Biomarkers in Hormone-Dependent Cancers Open
Background: The ESR2 gene encodes Estrogen Receptor-β1 (ERβ1), a putative tumor suppressor in hormone-dependent malignancies. Although ERβ biology has been studied extensively at the expression level, the functional impact of nonsynonymous…
View article: Oncogenic Potential and Molecular Disruptions of ESR2 Coding and UTRs Variants: An Integrative In Silico Analysis
Oncogenic Potential and Molecular Disruptions of ESR2 Coding and UTRs Variants: An Integrative In Silico Analysis Open
(1) Background: Estrogen Receptor Beta 1 (ERβ1), encoded by the ESR2 gene, plays a key tumor-suppressive role in hormone-dependent cancers. However, the impact of nonsynonymous single-nucleotide polymorphisms (nsSNPs) and untranslated regi…