Explanipedia

Spatial Transcriptomics Characterisation of Radionecrotic Changes in Glioblastoma Patients Open

Zaira Seferbekova, Markus Ritter, Gleb Ruckhovich, Sophia Schinkewitsch, Nela Koeberer , et al. · 2025

Background: IDH-wildtype Glioblastoma (GB) is the most prevalent primary CNS tumour in adults. The standard treatment involves radiotherapy, which can cause radionecrotic changes. Progressive GB and radionecrotic changes can be challenging…

KS03.6.A THE RECURRENT TISSUE STATES ACROSS ADULT GLIOMAS AS REVEALED BY SPATIAL TRANSCRIPTOMICS Open

Argyri Mathioudaki, Zaira Seferbekova, Markus Ritter, D Calafato, Gleb D. Rukhovich , et al. · 2025

BACKGROUND Adult gliomas are a diverse class of tumors with substantial molecular and pathological variation. While prior single-cell omics studies have characterized intratumoral heterogeneity, they often examined tumors in isolation, thu…

Rare variants in infection response protein pathways associated with sepsis in children Open

Dylan Lawless, Pauline Rogg, Manon Bouzereau, Robin Fallegger, Zaira Seferbekova , et al. · 2025

1 Abstract Sepsis is a major contributor to mortality in paediatric patients. We investigated the human genetic underpinnings of sepsis by analysing a large paediatric cohort with blood-culture confirmed sepsis through multi-tiered genomic…

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics Open

Michael Ritter, Christina Blume, Yiheng Tang, Areeba Patel, Bhuvic Patel , et al. · 2025

Single-cell and spatial transcriptomics analysis of non-small cell lung cancer Open

Marco De Zuani, Haoliang Xue, Jun Sung Park, Stefan C. Dentro, Zaira Seferbekova , et al. · 2024

Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer-related mortality worldwide. Tumour ecosystems feature diverse immune cell types. Myeloid cells, in particular, are prevalent and have a well-establ…

PATH-13. APPLICATIONS OF SPATIAL TRANSCRIPTOMICS FOR THE DIAGNOSTICS OF GLIOMAS Open

Michael Ritter, Christina Blume, Yiheng Tang, Bhuvic Patel, Areeba Patel , et al. · 2023

Due to their infiltrative growth, diffuse gliomas can pose a major challenge for neuropathologists. Lack of specific immunohistochemistry markers for some gliomas like IDH-wildtype glioblastoma can make it hard to identify the tumour cell …

OS10.8.A APPLICATIONS OF NOVEL FFPE BASED TECHNOLOGIES FOR THE DIAGNOSTICS OF GLIOMAS Open

Michael Ritter, Christina Blume, B. Patel, Yufang Tang, Areeba Patel , et al. · 2023

BACKGROUND Due to the lack of consistent tumour-cell specific markers, the diffuse brain invasion of glioblastoma (GB) presents a significant diagnostic challenge, especially for specimens with a low tumour cell fraction or scarce tissue. …

PATH-46. COMPUTATIONAL HISTOPATHOLOGY INFORMED RAPID TARGETED NANOPORE SEQUENCING ENABLES AFFORDABLE NEXT DAY REPORTING OF COMPREHENSIVE MOLECULAR MARKERS FOR CNS TUMOUR DIAGNOSTICS Open

Areeba Patel, Helin Dogan, Alexander W. Jung, Zaira Seferbekova, Alexander Payne , et al. · 2022

BACKGROUND Integrative brain tumour diagnostics indisputably requires comprehensive reporting of molecular markers. The 2021 WHO classification of central nervous system (CNS) tumours substantially increased the set of markers for routine …

High Rates of Genome Rearrangements and Pathogenicity of Shigella spp. Open

Zaira Seferbekova, Alexey Zabelkin, Yulia Yakovleva, Robert Afasizhev, Natalia O. Dranenko , et al. · 2021

Shigella are pathogens originating within the Escherichia lineage but frequently classified as a separate genus. Shigella genomes contain numerous insertion sequences (ISs) that lead to pseudogenisation of affected genes and an increase of…

A recently isolated human commensal <i>Escherichia coli</i> ST10 clone member mediates enhanced thermotolerance and tetrathionate respiration on a P1 phage‐derived IncY plasmid Open

Shady Mansour Kamal, Annika Cimdins, Changhan Lee, Fengyang Li, Alberto J. Martín‐Rodríguez , et al. · 2020

The ubiquitous human commensal Escherichia coli has been well investigated through its model representative E. coli K‐12. In this work, we initially characterized E. coli Fec10, a recently isolated human commensal strain of phylogroup A/se…

High rates of genome rearrangements and pathogenicity of<i>Shigella</i>spp Open

Zaira Seferbekova, Alexey Zabelkin, Yulia Yakovleva, Robert Afasizhev, Natalia O. Dranenko , et al. · 2020

Shigella are pathogens originating within the Escherichia lineage but frequently classified as a separate genus. Shigella genomes contain numerous insertion sequences (ISs) that lead to pseudogenization of affected genes and an increase of…

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