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View article: Developmental deviations of structural connectivity in youths with ADHD predict symptom and treatment outcomes
Developmental deviations of structural connectivity in youths with ADHD predict symptom and treatment outcomes Open
Attention-deficit/hyperactivity disorder (ADHD) lacks validated biomarkers to track symptom development or guide treatment selection in youth. We quantified individual deviations from normative age-related trajectories of white-matter stru…
View article: Distinct Roles of Cerebellar Afferent and Efferent Fiber Tracts in Craniocervical Dystonia
Distinct Roles of Cerebellar Afferent and Efferent Fiber Tracts in Craniocervical Dystonia Open
Background The cerebellum has been widely implicated in the pathogenesis of craniocervical dystonia (CCD). Subthalamic nucleus deep brain stimulation (STN‐DBS) has emerged as an effective therapy for CCD. However, the roles of cerebellar a…
View article: Normative Executive Function Development Reveals Age-Varying Mental Health Associations in Youth
Normative Executive Function Development Reveals Age-Varying Mental Health Associations in Youth Open
Summary IMPORTANCE Executive function (EF) is crucial for adolescent development and mental health. However, population-level benchmarks of EF growth and their relevance to psychiatric symptoms remain unclear, especially for non-Western po…
View article: Optimal stimulation site and fiber tracts in subthalamic deep brain stimulation for Meige syndrome
Optimal stimulation site and fiber tracts in subthalamic deep brain stimulation for Meige syndrome Open
Our study underscores the potential of optimizing stimulation sites and fibers to predict clinical improvement, and provides new insights into the ongoing efforts of precise surgical targeting and computer-assisted DBS programming.
View article: Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence
Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence Open
Importance Functional brain networks are associated with both behavior and genetic factors. To uncover biological mechanisms of psychopathology, it is critical to define how the spatial organization of these networks relates to genetic ris…
View article: Reproducible sex differences in personalised functional network topography in youth
Reproducible sex differences in personalised functional network topography in youth Open
Background A key step toward understanding psychiatric disorders that disproportionately impact female mental health is delineating the emergence of sex-specific patterns of brain organisation at the critical transition from childhood to a…
View article: Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning
Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning Open
The brain's multi-scale hierarchical organization supports functional segregation and integration. Characterizing the hierarchy of individualized multi-scale functional networks (FNs) is crucial for understanding these fundamental brain pr…
View article: Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition
Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition Open
The human cerebral cortex exhibits intricate interareal functional synchronization at the macroscale, with substantial individual variability in these functional connections. However, the spatial organization of functional connectivity (FC…
View article: Glioma-white matter tract interactions: A diffusion magnetic resonance imaging-based 3-tier classification and its clinical relevance
Glioma-white matter tract interactions: A diffusion magnetic resonance imaging-based 3-tier classification and its clinical relevance Open
Background This study proposed a classification system for the interaction between gliomas and white matter tracts, exploring its potential associations with clinical characteristics, tumor pathological subtypes, and patient outcomes. Meth…
View article: Developmental Variations in Recurrent Spatiotemporal Brain Propagations from Childhood to Adulthood
Developmental Variations in Recurrent Spatiotemporal Brain Propagations from Childhood to Adulthood Open
The brain undergoes profound structural and functional transformations from childhood to adolescence. Convergent evidence suggests that neurodevelopment proceeds in a hierarchical manner, characterized by heterogeneous maturation patterns …
View article: Spatial Heterogeneity and Subtypes of Functional Connectivity Development in Youth
Spatial Heterogeneity and Subtypes of Functional Connectivity Development in Youth Open
The brain functional connectome development is fundamental to neurocognitive growth in youth. While brain age prediction has been widely used to assess connectome development at the individual level, traditional approaches providing a glob…
View article: Dynamic switching between brain networks predicts creative ability
Dynamic switching between brain networks predicts creative ability Open
Creativity is hypothesized to arise from a mental state which balances spontaneous thought and cognitive control, corresponding to functional connectivity between the brain's Default Mode (DMN) and Executive Control (ECN) Networks. Here, w…
View article: Toward individual heterogeneity and neurobiological subtypes in attention-deficit/hyperactivity disorder
Toward individual heterogeneity and neurobiological subtypes in attention-deficit/hyperactivity disorder Open
Attention-deficit/hyperactivity disorder (ADHD) is a biologically and clinically heterogeneous neurodevelopmental condition, which hinders the identification of biologically rooted evidence for treatment choices and clinical predictions. I…
View article: Hierarchical individual variation and socioeconomic impact on personalized functional network topography in children
Hierarchical individual variation and socioeconomic impact on personalized functional network topography in children Open
These results offer insights into how SES influences neurodevelopment through personalized functional neuroanatomy in childhood, highlighting the cortex-wide, hierarchically organized plasticity of the functional networks in response to di…
View article: Transcranial low-level laser stimulation in the near-infrared-II region (1064 nm) for brain safety in healthy humans
Transcranial low-level laser stimulation in the near-infrared-II region (1064 nm) for brain safety in healthy humans Open
Our data indicate that 1064 nm laser tPBM does not induce adverse effects on brain structure or function, nor does it impair cognitive abilities. tPBM is safe for specific parameters, highlighting its good tolerability.
View article: Heterogenous brain activations across individuals localize to a common network
Heterogenous brain activations across individuals localize to a common network Open
Task functional magnetic resonance imaging research has generally shielded away from studying individuals due to the low reproducibility. Here, we propose that heterogeneous brain activations across individuals localize to a common network…
View article: Reproducible Sex Differences in Personalized Functional Network Topography in Youth
Reproducible Sex Differences in Personalized Functional Network Topography in Youth Open
A key step towards understanding psychiatric disorders that disproportionately impact female mental health is delineating the emergence of sex-specific patterns of brain organization at the critical transition from childhood to adolescence…
View article: Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence
Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence Open
Importance Functional brain networks are associated with both behavior and genetic factors. To uncover biological mechanisms of psychopathology, it is critical to define how the spatial organization of these networks relates to genetic ris…
View article: Unveiling the core functional networks of cognition: An ontology-guided machine learning approach
Unveiling the core functional networks of cognition: An ontology-guided machine learning approach Open
Deciphering the functional architecture that underpins diverse cognitive functions is fundamental quest in neuroscience. In this study, we employed an innovative machine learning framework that integrated cognitive ontology with functional…
View article: Morphological Brain Networks of White Matter: Mapping, Evaluation, Characterization, and Application
Morphological Brain Networks of White Matter: Mapping, Evaluation, Characterization, and Application Open
Although white matter (WM) accounts for nearly half of adult brain, its wiring diagram is largely unknown. Here, an approach is developed to construct WM networks by estimating interregional morphological similarity based on structural mag…
View article: Transcranial low-level laser stimulation in near infrared-II region for brain safety and protection
Transcranial low-level laser stimulation in near infrared-II region for brain safety and protection Open
Background: The use of near-infrared lasers for transcranial photobiomodulation (tPBM) offers a non-invasive method for influencing brain activity and is beneficial for various neurological conditions. Objective: To investigate the safety …
View article: Structural connectivity matures along a sensorimotor-association connectional axis in youth
Structural connectivity matures along a sensorimotor-association connectional axis in youth Open
Childhood and adolescence are associated with protracted developmental remodeling of cortico-cortical structural connectivity. However, how heterochronous development in white matter structural connectivity spatially and temporally unfolds…
View article: Unveiling the Core Functional Networks of Cognition: An Ontology-Guided Machine Learning Approach
Unveiling the Core Functional Networks of Cognition: An Ontology-Guided Machine Learning Approach Open
Deciphering the functional architecture that underpins diverse cognitive functions is fundamental quest in neuroscience. In this study, we employed an innovative machine learning framework that integrated cognitive ontology with functional…
View article: A general exposome factor explains individual differences in functional brain network topography and cognition in youth
A general exposome factor explains individual differences in functional brain network topography and cognition in youth Open
Childhood environments are critical in shaping cognitive neurodevelopment. With the increasing availability of large-scale neuroimaging datasets with deep phenotyping of childhood environments, we can now build upon prior studies that have…
View article: The Brain’s Topographical Organization Shapes Dynamic Interaction Patterns That Support Flexible Behavior Based on Rules and Long-Term Knowledge
The Brain’s Topographical Organization Shapes Dynamic Interaction Patterns That Support Flexible Behavior Based on Rules and Long-Term Knowledge Open
Adaptive behavior relies both on specific rules that vary across situations and stable long-term knowledge gained from experience. The frontoparietal control network (FPCN) is implicated in the brain's ability to balance these different in…
View article: Normative growth modeling of brain morphology reveals neuroanatomical heterogeneity and biological subtypes in children with ADHD
Normative growth modeling of brain morphology reveals neuroanatomical heterogeneity and biological subtypes in children with ADHD Open
Background Neuroimaging studies suggest substantial individual heterogeneity in brain phenotypes in attention-deficit/hyperactivity disorder (ADHD). However, how these individual-level brain phenotypes contribute to the identification of A…
View article: Predictable navigation through spontaneous brain states with cognitive-map-like representations
Predictable navigation through spontaneous brain states with cognitive-map-like representations Open
Just as navigating a physical environment, navigating through the landscapes of spontaneous brain states may also require an internal cognitive map. Contemporary computation theories propose modeling a cognitive map from a reinforcement le…
View article: The <i>p</i> factor outweighs the specific internalizing factor in predicting recurrences of adolescent depression
The <i>p</i> factor outweighs the specific internalizing factor in predicting recurrences of adolescent depression Open
Background The early prediction of adolescent depression recurrence poses a significant challenge in the field. This study aims to investigate and compare the abilities of the general psychopathology factor ( p ) and the specific internali…