Explanipedia

Management of spinal chordomas and sarcomas: WFNS spine committee recommendations Open

Mehmet Zileli, А. О. Гуща, Salman Sharif, Francesca Costa, Zan Chen , et al. · 2025

Preoperative coronal imbalance in degenerative scoliosis: a study on coronal and sagittal spinal-pelvic parameters——a retrospective study Open

Mei-Fang Wu, Yusheng Bao, Hao Zhang, Yanzhe Ning, Zan Chen , et al. · 2025

Incidence, epidemiology, classification and radiology of primary vertebral tumors: WFNS spine committee recommendations Open

Boyan Zhang, Can Zhang, Mirza Pojskić, Mehmet Zileli, Salman Sharif , et al. · 2025

TERT promoter C250T mutation in a recurrent cervical chordoid meningioma: a unique case report Open

Xihong Shao, Zhongying Xu, Penghao Liu, Teng Zhang, Feng Yang , et al. · 2025

General evaluation and decision-making in primary vertebra tumors: WFNS spine committee recommendations Open

İdris Avcı, Onur Yaman, Mehmet Zileli, Francesco Costa, А. О. Гуща , et al. · 2025

Management of benign primary vertebral tumors: WFNS spine committee recommendations Open

Francesco Costa, Francesco Restelli, Niccolò Innocenti, Corinna C. Zygourakis, Zan Chen , et al. · 2025

One-stage posterior debridement approach combined with autogenous bone grafting and internal fixation for the treatment of adult thoracic or lumbar suppurative spondylitis via the multifidus and longissimus interspaces Open

Yifan Guo, Yunbo Yang, Zan Chen, Daxiong Feng, Fei Lei · 2025

This one-stage posterior approach is effective and feasible for adult single - level thoracic or lumbar suppurative spondylitis, protecting paravertebral muscles and posterior ligament complexes. However, further studies with larger sample…

Reconstructing Structure and Function Post Spinal Cord Injury by Facilitating Novel Integration Therapy and Neuromodulation Open

Qiqi Yang, Chenyuan Ding, Fengzeng Jian, Zan Chen, Zhongying Xu , et al. · 2025

Spinal cord injury (SCI) has been a research hotspot for its poor prognosis and limited effects in current treatment methods. Consistent hostile responses in damaged regions and functional incapabilities can lead to major complications. Mo…

Psl: Prototype Swapping Learning for Modality Imbalance Open

Zan Chen, Sheng Zhao, Meng Xu, Wang Bo, Shiding Sun , et al. · 2025

Spatiotemporal spinal cord stimulation with real‐time triggering exoskeleton restores walking capability: a case report Open

Penghao Liu, Yuanchen Cheng, Zhongying Xu, Xiaoyu Li, Zan Chen , et al. · 2024

Objective Motor recovery is challenging for spinal cord injury (SCI), especially in low‐level SCI. Methods A 16‐year‐old patient with complete SCI at T12 presented flaccid paralysis and inability to control defecation and was scored as ASI…

The clinical management and efficacy of metagenomic next-generation sequencing in patients with pyogenic spinal infection: a single-center cohort study Open

M. Qi, Yueqi Du, Jian‐Long Guan, Jiao Ma, Wenwen Li , et al. · 2024

Metagenomic next-generation sequencing is effective in managing pyogenic spinal infections by facilitating rapid and sensitive detection of pathogens. This technique improves the timeliness and accuracy of diagnosis, highlighting its poten…

Analysis of Failed Posterior Fossa Decompression and an Effective Revision Surgery in Patients with Basilar Invagination and Atlantoaxial Dislocation Open

Maoyang Qi, Yueqi Du, Boyan Zhang, Xin Zong, Can Zhang , et al. · 2024

Objective The objective of this study was to analyze failed posterior fossa decompression (PFD) in patients with basilar invagination and atlantoaxial dislocation (BI‐AAD). Revision surgery in these patients is challenging and has been rar…

Application of the “Klotski Technique” in Cervical Ossification of the Posterior Longitudinal Ligament With En Bloc Type Dura Ossification Open

Jian Guan, K Li, Chenghua Yuan, Wanru Duan, Kai Wang , et al. · 2024

Objective: The anterior controllable antedisplacement and fusion (ACAF) technique is a new procedure for the treatment of cervical ossification of the posterior longitudinal ligament (OPLL) that requires management of the disc adjacent to …

Analysis of Failed Atlantoaxial Reduction: Causes of Failure and Strategies for Revision Open

Boyan Zhang, Yueqi Du, Can Zhang, Maoyang Qi, Hongfeng Meng , et al. · 2024

Objective The craniovertebral junction (CVJ) presents intricate anatomical challenges. In severe or irreducible malformations, complications such as reduction loss and fixation failure may occur, necessitating revision surgery. The posteri…

Modified Thoracoplasty for Rib Hump Deformity in Scoliosis Patients: A Case-Control Study Open

Hao Yuan, Minglang Wang, Fei Lei, Lipeng Zheng, Zan Chen , et al. · 2024

MTP provides enhanced correction of thoracic curve and rib hump deformity without significantly increasing pulmonary function impairment or complication rates. It also improves patients' self-image, making it a valuable addition to PSF in …

Interleukin-7 expression by CAR-T cells improves CAR-T cell survival and efficacy in chordoma Open

Huantong Wu, Zhuofan Xu, Maoyang Qi, Penghao Liu, Boyan Zhang , et al. · 2024

Chordoma is a rare bone tumor that frequently recurs after surgery, and the prognosis is poor with current treatments. This study aimed to identify potential novel immunotherapeutic targets for chordomas by identifying target proteins in c…

The pons as an optimal background reference region for spinal 18F-FET PET/MRI evaluation Open

Jing Huang, Jiyuan Wang, Bixiao Cui, Hongwei Yang, Defeng Tian , et al. · 2024

Background This study aims to evaluate the effect of various background reference regions on spinal 18 F-FET PET imaging, with a focus on distinguishing between spinal tumors and myelitis. To enhance diagnostic accuracy, we investigated th…

Benchmarking Large Language Models for Cervical Spondylosis Open

Boyan Zhang, Yueqi Du, Wanru Duan, Zan Chen · 2024

Cervical spondylosis is the most common degenerative spinal disorder in modern societies. Patients require a great deal of medical knowledge, and large language models (LLMs) offer patients a novel and convenient tool for accessing medical…

FET PET provides adjunctive value to FDG PET in distinction of spinal cord tumors Open

Penghao Liu, Jing Huang, Wanru Duan, Tianbin Song, Jiyuan Wang , et al. · 2024

¹⁸F-FET PET presented comparable diagnostic performance to ¹⁸F-FDG PET in differentiating HGTs, LGTs, and NTDs, but exhibited particular utility in MNGT and inflammatory lesions.

The Pons as an Optimal Background Reference Region for Spinal 18F-FET PET/MRI Evaluation Open

Jing Huang, Jiyuan Wang, Bixiao Cui, Hongwei Yang, Defeng Tian , et al. · 2024

Background This study aims to evaluate the effect of various background reference regions on spinal ¹⁸F-FET PET imaging, with a focus on distinguishing between spinal tumors and myelitis. To enhance diagnostic accuracy, we inves…

Diffusion Tensor Imaging Identifies Cervical Spondylosis, Myelitis, and Spinal Cord Tumors Open

Jiyuan Wang, Jing Huang, Bixiao Cui, Hongwei Yang, Defeng Tian , et al. · 2024

Background: Diffusion tensor imaging (DTI) has been increasingly recognized for its capability to study microstructural changes in the neuropathology of brain diseases. However, the optimal DTI metric and its diagnostic utility for a varie…

Randomized controlled study protocol for surgical treatment of irreducible atlantoaxial dislocation Open

Shilin Xue, Nanfang Xu, Zan Chen, Fangcai Li, Xiangyang Wang , et al. · 2024

Introduction: Irreducible atlantoaxial dislocation (IAAD) poses a complex surgical challenge, necessitating a critical evaluation of available strategies. Surgical approaches under consideration encompass the simple posterior approach and …

Single-cell sequencing reveals VEGFR as a potential target for CAR-T cell therapy in chordoma Open

Huantong Wu, Xinqiang Li, Boyan Zhang, Penghao Liu, Maoyang Qi , et al. · 2024

Role of Preoperative Albumin Quotient in Surgical Planning for Posttraumatic Syringomyelia: A Comparative Cohort Study Open

Pingchuan Xia, Houyuan Lv, Chenghua Yuan, Wanru Duan, Jiachen Wang , et al. · 2024

Objective: Surgical procedures for patients with posttraumatic syringomyelia (PTS) remain controversial. Until now, there have been no effective quantitative evaluation methods to assist in selecting appropriate surgical plans before surge…

The Natural History of Chiari Malformation-Syringomyelia: Evidence of Bidirectional Flow of Central Canal Fluid within the Spinal Cord Open

Chenghua Yuan, Jian Guan, Yueqi Du, Qingyu Yao, Lei Zhang , et al. · 2024

Anterior controllable antedisplacement and fusion as revision surgery for the treatment of OPLL after anterior and posterior decompression: A case report Open

Tianyu Jin, Wanru Duan, Zan Chen · 2023

Background: In cases of cervical ossification of the posterior longitudinal ligament (OPLL), when initial anterior or posterior decompression fails to yield satisfactory results, the alternative approach is often chosen for revision surger…

Mazor X Robot-Assisted Pedicle Screw Placement: A Case Series Open

Hongyi Wang, Yueqi Du, Linpeng Li, Can Zhang, Wanru Duan , et al. · 2023

Pedicle screw placement is a well-established procedure in spine surgeries, and the utilization of robots in spinal surgery has been on the rise. This study aims to investigate the accuracy and screw placement time associated with the use …

Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma Open

Lei Cheng, Wanru Duan, Jian Guan, Kai Wang, Zhenlei Liu , et al. · 2023

Objective: Although cerebrospinal fluid (CSF)-based liquid biopsy was proved to be practical in molecular analysis of intracranial gliomas, liquid biopsy of primary intramedullary astrocytoma was rarely reported. Given the distinct genomic…

Intra-articular Distraction Versus Decompression to Treat Basilar Invagination Without Atlantoaxial Dislocation: A Retrospective Cohort Study of 54 Patients Open

Boyan Zhang, Maoyang Qi, Xin Zong, Yueqi Du, Can Zhang , et al. · 2023

Objective: The surgical management of basilar invagination without atlantoaxial dislocation (type B basilar invagination) remains controversial. Hence, we have reported the use of posterior intra-articular C1–2 facet distraction, fixation,…

Predicting deep surgical site infection in patients receiving open posterior instrumented thoracolumbar surgery: A-DOUBLE-SSI risk score – a large retrospective multicenter cohort study in China Open

Lei Cheng, Jiesheng Liu, Liyi Lian, Wanru Duan, Jian Guan , et al. · 2023

Background: To develop a practical prediction model to predict the risk of deep surgical site infection (SSI) in patients receiving open posterior instrumented thoracolumbar surgery. Methods: Data of 3419 patients in four hospitals from 1 …

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