Explanipedia

Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice Open

Homa Majd, Ryan M. Samuel, Andrius Cesiulis, Jonathan T. Ramirez, Ali Kalantari‐Hesari , et al. · 2025

Gastrointestinal (GI) motility disorders represent a major medical challenge, with few effective therapies available. These disorders often result from dysfunction of inhibitory nitric oxide (NO)-producing motor neurons in the enteric nerv…

A deep learning phenome wide association study of the electrocardiogram Open

J. Weston Hughes, John Theurer, Miloš Vukadinovic, Albert J. Rogers, Sulaiman Somani , et al. · 2025

Aims Deep learning methods have shown impressive performance in detecting a range of diseases from electrocardiogram (ECG) waveforms, but the breadth of diseases that can be detected with high accuracy remains unknown, and in many cases th…

UniTox: Leveraging LLMs to Curate a Unified Dataset of Drug-Induced Toxicity from FDA Labels Open

Jake Silberg, Kyle Swanson, E Simón, Angela Zhang, Zaniar Ghazizadeh , et al. · 2024

Drug-induced toxicity is one of the leading reasons new drugs fail clinical trials. Machine learning models that predict drug toxicity from molecular structure could help researchers prioritize less toxic drug candidates. However, current …

Combined GWAS and single cell transcriptomics uncover the underlying genes and cell types in disorders of gut-brain interaction Open

Alireza Majd, Mikayla N Richter, Ryan M. Samuel, Andrius Cesiulis, Zaniar Ghazizadeh , et al. · 2023

Disorders of gut-brain interaction (DGBIs), formerly known as functional gastrointestinal disorders, are extremely common and historically difficult to manage. This is largely because their cellular and molecular mechanisms have remained p…

Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy Open

Homa Majd, Sadaf Amin, Zaniar Ghazizadeh, Andrius Cesiulis, Edgardo J. Arroyo , et al. · 2023

Schwann cells (SCs) are the primary glia of the peripheral nervous system. SCs are involved in many debilitating disorders, including diabetic peripheral neuropathy (DPN). Here, we present a strategy for deriving SCs from human pluripotent…

Tyrosine kinase inhibitor–associated ventricular arrhythmias: a case series and review of literature Open

Muhammad Fazal, Chen Wei, Katherine Lee Chuy, Kifah Hussain, Sofia Gomez , et al. · 2022

Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy Open

Homa Majd, Sadaf Amin, Zaniar Ghazizadeh, Andrius Cesiulis, Edgardo J. Arroyo , et al. · 2022

SUMMARY Schwann cells (SCs) are the myelinating and non-myelinating glia of the peripheral nervous system (PNS) and are essential for its function. Defects in SCs are associated with many PNS disorders including diabetic peripheral neuropa…

Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination Open

Manan Pareek, Jeremy Steele, Jeremy D. Asnes, Lauren A. Baldassarre, Linda R. Casale , et al. · 2022

A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells Open

Zaniar Ghazizadeh, Jiajun Zhu, Faranak Fattahi, Alice Tang, Xiaolu Sun , et al. · 2022

hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function Open

Homa Majd, Ryan M. Samuel, Jonathan T. Ramirez, Ali Kalantari‐Hesari, Kevin Barber , et al. · 2022

The enteric nervous system (ENS) plays a central role in gut physiology and mediating the crosstalk between the gastrointestinal (GI) tract and other organs. The human ENS has remained elusive, highlighting the need for an in vitro modelin…

Retraction Note to: Transient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells Open

Zaniar Ghazizadeh, Hassan Rassouli, Hananeh Fonoudi, Mehdi Alikhani, Mahmood Talkhabi , et al. · 2021

Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy Open

Zaniar Ghazizadeh, Faranak Fattahi, Mehdi Mirzaei, Delger Bayersaikhan, Jaesuk Lee , et al. · 2021

(Stem Cell Reports 10, 848–859; March 13, 2018) The authors wish to make the following corrections to Figures 5C and S4G of this article. The authors declare that these mistakes do not affect the results and conclusions of the study. In Fi…

Relation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients With Coronavirus Disease 2019 (from the Yale COVID-19 Cardiovascular Registry) Open

Manan Pareek, Avinainder Singh, Lina Vadlamani, Maxwell Eder, Justin Pacor , et al. · 2021

Myopericarditis after Covid-19 Vaccination – a Case Series Open

Manan Pareek, Jeremy D. Asnes, Lauren A. Baldassarre, Linda R. Casale, Nihar R. Desai , et al. · 2021

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Open

Ryan M. Samuel, Homa Majd, Mikayla N Richter, Zaniar Ghazizadeh, Seyedeh M. Zekavat , et al. · 2020

Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Open

Zaniar Ghazizadeh, Homa Majd, Mikayla N Richter, Ryan M. Samuel, Seyedeh M. Zekavat , et al. · 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has led to a global health crisis, and yet our understanding of the disease pathophysiology and potential treatment options remains limited. SARS-CoV-2 infection occurs…

Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation Open

Zaniar Ghazizadeh, Tuomas Kiviniemi, Sigurast Olafsson, David Plotnick, Manu Beerens , et al. · 2019

Background: Atrial fibrillation (AF) is the most common clinical arrhythmia and is associated with heart failure, stroke, and increased mortality. The myocardial substrate for AF is poorly understood because of limited access to primary hu…

A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity Open

Su‐Yi Tsai, Zaniar Ghazizadeh, Houjun Wang, Sadaf Amin, Francis A. Ortega , et al. · 2019

Aims Human embryonic stem cells (hESCs) can be used to generate scalable numbers of cardiomyocytes (CMs) for studying cardiac biology, disease modelling, drug screens, and potentially for regenerative therapies. A fluorescence-based report…

A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival Open

Ting Zhou, Tae Wan Kim, Chi Nok Chong, Lei Tan, Sadaf Amin , et al. · 2018

Common disorders, including diabetes and Parkinson’s disease, are caused by a combination of environmental factors and genetic susceptibility. However, defining the mechanisms underlying gene-environment interactions has been challenging d…

Discovery of a drug candidate for GLIS3-associated diabetes Open

Sadaf Amin, Brandoch D. Cook, Ting Zhou, Zaniar Ghazizadeh, Raphaël Lis , et al. · 2018

GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology. Previous attempts to recapitulate disease-relevant phenotypes in GLIS3 −/− β-like cells have b…

Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy Open

Zaniar Ghazizadeh, Faranak Fattahi, Mehdi Mirzaei, Delger Bayersaikhan, Jaesuk Lee , et al. · 2018

The LIM-homeodomain transcription factor ISL1 marks multipotent cardiac progenitors that give rise to cardiac muscle, endothelium, and smooth muscle cells. ISL1⁺ progenitors can be derived from human pluripotent stem cells, but …

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells Open

Zaniar Ghazizadeh, Der-I Kao, Sadaf Amin, Brandoch D. Cook, Sahana D. Rao , et al. · 2017

The Effect of Hindsight Bias on Psychiatrists’ Clinical Judgment: A Randomized Controlled Trials Open

Mohammad Arbabi, Babak Mostafazadeh Davani, Majid Sadeghi Najafabadi, Ali Akbar Nejati Safa, Zaniar Ghazizadeh , et al. · 2017

Objectives: Hindsight bias is inevitable in retrospective peer reviews, especially in medical settings.Psychiatrists are highly at risk of hindsight bias, because of the repeated patient hospitalization and the use of medications with a lo…

Analysis of serum heat shock protein 70 (HSPA1A) concentrations for diagnosis and disease activity monitoring in patients with rheumatoid arthritis Open

Seyed Reza Najafizadeh, Zaniar Ghazizadeh, Arash Aghajani Nargesi, Masoud Mahdavi, Shabnam Abtahi , et al. · 2015

Zaniar Ghazizadeh YOU? Author Swipe