Žarko Alfirević
YOU?
Author Swipe
View article: INSPECT-SR: a tool for assessing trustworthiness of randomised controlled trials
INSPECT-SR: a tool for assessing trustworthiness of randomised controlled trials Open
Precis The integrity of evidence synthesis is threatened by problematic randomised controlled trials (RCTs). These are RCTs where there are serious concerns about the trustworthiness of the data or findings. This could be due to research m…
View article: Trustworthiness assessment of published clinical trials -- literature review of domains and questions
Trustworthiness assessment of published clinical trials -- literature review of domains and questions Open
View article: Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study
Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study Open
Background In the United Kingdom, pregnant women are offered two scans: at 11–14 and 18–20 weeks’ gestation. Current guidance supports fetal anatomical screening at the second scan, but evidence suggests earlier detection is possible. Obje…
View article: How far can AI help with assessing the trustworthiness of clinical trial publications? Review of concepts, methods, and questions.
How far can AI help with assessing the trustworthiness of clinical trial publications? Review of concepts, methods, and questions. Open
View article: The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review
The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review Open
Background Systematic reviews, such as those prepared by Cochrane, are the strongest evidence on which to base recommendations in clinical guidelines. Network meta-analysis (NMA) can be used to combine the results of studies to compare mul…
View article: The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT
The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT Open
Background Severe early-onset intrauterine growth restriction is associated with stillbirth, neonatal death and neurodevelopmental impairment. There is no treatment for intrauterine growth restriction with timely delivery being the only ma…
View article: FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregnancy – protocol for a prospective multicentre mixed-methods feasibility study
FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregnancy – protocol for a prospective multicentre mixed-methods feasibility study Open
Introduction Selective fetal growth restriction (sFGR) in monochorionic twin pregnancy, defined as an estimated fetal weight (EFW) of one twin <10th centile and EFW discordance ≥25%, is associated with stillbirth and neurodisability for bo…
View article: Trustworthiness assessment of published clinical trials: Literature review of domains and questions
Trustworthiness assessment of published clinical trials: Literature review of domains and questions Open
Background Historically, peer reviewing has focused on the importance of research questions/hypotheses, appropriateness of research methods, risk of bias, and quality of writing. Until recently, the issues related to trustworthiness—includ…
View article: Diagnosis and management of selective fetal growth restriction in monochorionic twin pregnancies: A cross‐sectional international survey
Diagnosis and management of selective fetal growth restriction in monochorionic twin pregnancies: A cross‐sectional international survey Open
Objective To identify current practices in the management of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies. Design Cross‐sectional survey. Setting International. Population Clinicians involve…
View article: Neurodevelopmental outcomes at 2 years in children who received sildenafil therapy in utero: The <scp>STRIDER randomised controlled trial</scp>
Neurodevelopmental outcomes at 2 years in children who received sildenafil therapy in utero: The <span>STRIDER randomised controlled trial</span> Open
Objective Severe early‐onset fetal growth restriction (FGR) causes stillbirth, neonatal death and neurodevelopmental impairment. Poor maternal spiral artery remodelling maintains vasoactive responsiveness but is susceptible to treatment wi…
View article: Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort
Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort Open
Background Improved Pregnancy Outcomes via Early Detection (IMPROvED) is a multi-centre, European phase IIa clinical study. The primary aim of IMPROvED is to enable the assessment and refinement of innovative prototype preeclampsia risk as…
View article: ISUOG Practice Guidelines: invasive procedures for prenatal diagnosis
ISUOG Practice Guidelines: invasive procedures for prenatal diagnosis Open
These guidelines may have been translated, from the originals published by ISUOG, by recognized experts in the field and have been independently verified by reviewers with a relevant first language. Although all reasonable endeavors have b…
View article: Oral misoprostol alone, compared with oral misoprostol followed by oxytocin, in women induced for hypertension of pregnancy: A multicentre randomised trial
Oral misoprostol alone, compared with oral misoprostol followed by oxytocin, in women induced for hypertension of pregnancy: A multicentre randomised trial Open
Objective To assess whether, in those requiring continuing uterine stimulation after cervical ripening with oral misoprostol and membrane rupture, augmentation with low‐dose oral misoprostol is superior to intravenous oxytocin. Design Open…
View article: Oral misoprostol alone compared to oral misoprostol followed by oxytocin in India: a multicentre randomised trial in women induced for hypertension of pregnancy.
Oral misoprostol alone compared to oral misoprostol followed by oxytocin in India: a multicentre randomised trial in women induced for hypertension of pregnancy. Open
Objective : To assess whether, in those requiring ongoing uterine stimulation after cervical ripening with oral misoprostol and membrane rupture, augmentation with low dose oral misoprostol is superior to intravenous oxytocin. Design: Open…
View article: ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth (translation into Russian)
ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth (translation into Russian) Open
These guidelines may have been translated, from the originals published by ISUOG, by recognized experts in the field and have been independently verified by reviewers with a relevant first language. Although all reasonable endeavors have b…
View article: Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions
Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions Open
Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and…
View article: Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort
Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort Open
Background Improved Pregnancy Outcomes via Early Detection (IMPROvED) is a multi-centre, European phase IIa clinical study. The primary aim of IMPROvED is to enable the assessment and refinement of innovative prototype preeclampsia risk as…
View article: Trustworthiness assessment as an inclusion criterion for systematic reviews—What is the impact on results?
Trustworthiness assessment as an inclusion criterion for systematic reviews—What is the impact on results? Open
Background There is increasing concern that a significant proportion of randomized controlled trials (RCTs) included in Cochrane reviews may not be trustworthy. Applying the Cochrane Pregnancy and Childbirth Trustworthiness Screening Tool …
View article: Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort
Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort Open
Background Improved Pregnancy Outcomes via Early Detection (IMPROvED) is a multi-centre, European phase IIa clinical study. The primary aim of IMPROvED is to enable the assessment and refinement of innovative prototype preeclampsia risk as…
View article: Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis
Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis Open
Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role i…
View article: Letter to the editor: Integrity of randomized clinical trials: Performance of integrity tests and checklists requires assessment
Letter to the editor: Integrity of randomized clinical trials: Performance of integrity tests and checklists requires assessment Open
View article: Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions
Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions Open
Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and…
View article: Trustworthiness assessment as an inclusion criterion for systematic reviews -- what is the impact on results?
Trustworthiness assessment as an inclusion criterion for systematic reviews -- what is the impact on results? Open
BACKGROUND There is increasing concern that a significant proportion of randomised controlled trials (RCTs) included in Cochrane reviews may not be trustworthy. Applying a trustworthiness screening tool (TST) has already had a clinically i…
View article: Few randomized trials in preterm birth prevention meet predefined usefulness criteria
Few randomized trials in preterm birth prevention meet predefined usefulness criteria Open
View article: Preterm Prelabour Rupture Of Membranes (PPROM) before 23 weeks gestation: A prospective observational study
Preterm Prelabour Rupture Of Membranes (PPROM) before 23 weeks gestation: A prospective observational study Open
Objectives Describe infant and maternal outcomes of a national cohort of women with preterm prelabour rupture of membranes (PPROM) under 23 weeks gestation. Design Prospective national population-based cohort study using the UK Obstetric S…
View article: Non‐immune hydrops fetalis: a practical guide for obstetricians
Non‐immune hydrops fetalis: a practical guide for obstetricians Open
Key content Hydrops fetalis is the accumulation of two or more fetal fluid collections, including pericardial effusion, pleural effusion(s), ascites and skin oedema. In the absence of red cell alloimmunisation, hydrops fetalis is non‐immun…
View article: Assessing the usefulness of randomised trials in obstetrics and gynaecology
Assessing the usefulness of randomised trials in obstetrics and gynaecology Open
This article includes Author Insights, a video abstract available at: https://vimeo.com/785911255
View article: Modified Delphi study of ultrasound signs associated with placenta accreta spectrum
Modified Delphi study of ultrasound signs associated with placenta accreta spectrum Open
Objective To determine, by expert consensus through a modified Delphi process, the role of standardized and new ultrasound signs in the prenatal evaluation of patients at high risk of placenta accreta spectrum (PAS). Methods A systematic r…
View article: Methods of induction of labour: a network meta-analysis
Methods of induction of labour: a network meta-analysis Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To compare the effectiveness and safety profiles for the different methods of cervical ripening and labour induction at or beyond term labour using net…
View article: 2-Year Neurodevelopmental Outcomes in Children Who Received Sildenafil Therapy in Utero: The STRIDER RCT
2-Year Neurodevelopmental Outcomes in Children Who Received Sildenafil Therapy in Utero: The STRIDER RCT Open