Zhi Zhong
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View article: Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co‐Inhibition of <scp>TGF</scp>‐β and <scp>GSK</scp>‐3 Signalling
Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co‐Inhibition of <span>TGF</span>‐β and <span>GSK</span>‐3 Signalling Open
Background and Aims Liver fibrosis, a progressive condition driven by chronic liver injury and excessive scar tissue formation, can lead to cirrhosis, a life‐threatening disease. Activation of hepatic stellate cells (HSCs) is central to fi…
View article: The Chemistry of Phytoplankton
The Chemistry of Phytoplankton Open
Phytoplankton have a high potential for CO2 capture and conversion. Besides being a vital food source at the base of oceanic and freshwater food webs, microalgae provide a critical platform for producing chemicals and consumer products. En…
View article: PFKP inhibition protects against pathological cardiac hypertrophy by regulating protein synthesis
PFKP inhibition protects against pathological cardiac hypertrophy by regulating protein synthesis Open
Metabolic reprogramming precedes most alterations during pathological cardiac hypertrophy and heart failure (HF). Recent studies have revealed that Phosphofructokinase, platelet (PFKP) has a wealth of metabolic and non-metabolic functions.…
View article: Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity
Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity Open
Overdose of acetaminophen (APAP) produces fulminant hepatic necrosis. The underlying mechanism of APAP hepatotoxicity involves mitochondrial dysfunction, including mitochondrial oxidant stress and the onset of mitochondrial permeability tr…
View article: LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a
LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a Open
Effective therapy for liver fibrosis is lacking. Here, we examined whether LP340, the lead candidate of a new-generation of hydrazide-based HDAC1,2,3 inhibitors (HDACi), decreases liver fibrosis. Liver fibrosis was induced by CCl 4 treatme…
View article: Effect of cryotherapy and ALA-PDT therapy on skin cancer
Effect of cryotherapy and ALA-PDT therapy on skin cancer Open
Objective: to study the effect of cryotherapy and ALA-PDT therapy on skin cancer. Methods: this study selected 60 patients with skin cancer admitted to Ankang People’s Hospital of Shaanxi Province from January 2014 to December 2019. Accord…
View article: Highly efficient conversion of mouse fibroblasts into functional hepatic cells under chemical induction
Highly efficient conversion of mouse fibroblasts into functional hepatic cells under chemical induction Open
Previous studies have shown that hepatocyte-like cells can be generated from fibroblasts using either lineage-specific transcription factors or chemical induction methods. However, these methods have their own deficiencies that restrict th…
View article: PC3T: a signature-driven predictor of chemical compounds for cellular transition
PC3T: a signature-driven predictor of chemical compounds for cellular transition Open
Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and high…
View article: LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice
LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice Open
Objectives Some histone deacetylase (HDAC) isoforms contribute to ischaemia/reperfusion (IR) injury (IRI). Here, we examined whether LP342, the lead candidate of a new generation of hydrazide-based HDAC inhibitors (HDACi), decreases hepati…
View article: Reservoir Characterization of Special Dolomite Rock of Fengcheng Formation in Junggar Basin, China
Reservoir Characterization of Special Dolomite Rock of Fengcheng Formation in Junggar Basin, China Open
Dolomites and eruptive rocks are well-developed in the Permian Fengcheng Formation in Junggar Basin in China, in which oil and gas are accumulated extensively. Until now, high-yield industrial oil and gas flows have been obtained in the do…
View article: Quantitative and Comprehensive Prediction of Shale Oil Sweet Spots in Qingshankou Formation, Songliao Basin
Quantitative and Comprehensive Prediction of Shale Oil Sweet Spots in Qingshankou Formation, Songliao Basin Open
The mud shale of Qingshankou Formation in Songliao Basin is the main rock source and contains rich shale oil resources. The successful development of shale oil depends on evaluating and optimizing the “sweet spots”. To accurately identify …
View article: Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice
Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice Open
Oxidative stress plays an important role in acetaminophen (APAP)-induced hepatotoxicity. Platanosides (PTSs) isolated from the American sycamore tree (Platanus occidentalis) represent a potential new four-molecule botanical drug class of a…
View article: Small Molecule‐Induced Differentiation As a Potential Therapy for Liver Cancer
Small Molecule‐Induced Differentiation As a Potential Therapy for Liver Cancer Open
Despite the efficacy demonstrated by immunotherapy recently, liver cancer still remains one of the deadliest cancers, mainly due to heterogeneity of this disease. Continuous exploration of new therapeutics is therefore necessary. Chemical‐…
View article: Effect of cryotherapy and ALA-PDT therapy on skin cancer
Effect of cryotherapy and ALA-PDT therapy on skin cancer Open
Objective: to study the effect of cryotherapy and ALA-PDT therapy on skin cancer. Methods: this study selected 60 patients with skin cancer admitted to Ankang People’s Hospital of Shaanxi Province from January 2014 to December 2019. Accord…
View article: Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice
Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice Open
Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In Type 2, mitochondrial depolarization (mtDepo) initiates mitophagy to …
View article: 松辽盆地青山口组页岩有机碳含量分布特征
松辽盆地青山口组页岩有机碳含量分布特征 Open
摘要: 总有机碳（TOC）含量是页岩油气资源量评价的关键参数之一.为定量分析松辽盆地青山口组页岩TOC含量分布特征，预测有利勘探区，以测井资料为基础，首先建立研究区构造模型，应用恢复古埋深法计算镜质体反射率（Ro），通过∆logR方法预测研究区TOC含量，最后利用地质统计学方法建立了研究区页岩TOC三维量化模型.结果表明，纵向上，青一段页岩TOC含量整体分布在0%~4%范围，青二段和青三段TOC含量明显低于青一段.平面上，青一段TOC含量在三肇凹陷南部及朝阳沟阶地中部最高，…
View article: Free Radical-Dependent Dysfunction of Small-for-Size Rat Liver Grafts: Prevention by Plant Polyphenols
Free Radical-Dependent Dysfunction of Small-for-Size Rat Liver Grafts: Prevention by Plant Polyphenols Open
BACKGROUND & AIMS: The mechanisms by which small-for-size liver grafts decrease survival remain unclear. This study investigated the role of free radicals in injury to small-for-size grafts. METHODS: Rat liver explants were reduced in size…
View article: Viral delivery of superoxide dismutase gene reduces cyclosporine A-induced nephrotoxicity
Viral delivery of superoxide dismutase gene reduces cyclosporine A-induced nephrotoxicity Open
BACKGROUND: Cyclosporine A (CsA) increases free radical formation in the kidney. Accordingly, this study investigated whether gene delivery of superoxide dismutase (SOD) reduced radical production and nephrotoxicity caused by CsA. METHODS:…
View article: NIM811 Prevents Mitochondrial Dysfunction, Attenuates Liver Injury, and Stimulates Liver Regeneration After Massive Hepatectomy
NIM811 Prevents Mitochondrial Dysfunction, Attenuates Liver Injury, and Stimulates Liver Regeneration After Massive Hepatectomy Open
Massive hepatectomy (MHX) leads to failure of remnant livers. Excessive metabolic burden in remnant livers may cause mitochondrial dysfunction. This study investigated whether blockade of the mitochondrial permeability transition (MPT) wit…
View article: Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats
Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats Open
Our previous studies showed that an extract from Camellia sinenesis (green tea), which contains several polyphenols, attenuates nephrotoxicity caused by cyclosporine A (CsA). Since polyphenols are stimulators of mitochondrial biogenesis (M…
View article: Inhibition of transforming growth factor-β/Smad signaling improves regeneration of small-for-size rat liver grafts
Inhibition of transforming growth factor-β/Smad signaling improves regeneration of small-for-size rat liver grafts Open
Transforming growth factor-β (TGF-β) is a potent inhibitor of cell proliferation. This study investigated whether overexpression of Smad7, which blocks TGF-β–induced activation of Smad2/3, could prevent the suppression of regeneration of s…
View article: Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition
Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition Open
Graft failure after liver transplantation may involve mitochondrial dysfunction. We examined whether prevention of mitochondrial injury would improve graft function. Orthotopic rat liver transplantation was performed after 18 hours' cold s…
View article: Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats
Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats Open
BackgroundReactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced during hemorrhagic shock and resuscitation (H/R), which may contribute to multiple organ failure. The Aim of this study was to test the hypothesis tha…
View article: Glycine reduces platelet aggregation
Glycine reduces platelet aggregation Open
It has been demonstrated that a wide variety of white blood cells and macrophages (i.e. Kupffer cells, alveolar and peritoneal macrophages and neutrophils) contain glycine-gated chloride channels. Binding of glycine on the receptor stimula…