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View article: GLP-1 receptor agonist increase retained gastric contents on EGD and same-day colonoscopy reduces this risk
GLP-1 receptor agonist increase retained gastric contents on EGD and same-day colonoscopy reduces this risk Open
Introduction With the rise in glucagon-like peptide 1 receptor agonist (GLP-1RA) medication usage for Type 2 diabetes mellitus and weight loss, concerns have been raised regarding safety and primary aspiration risk when undergoing anesthes…
View article: A Case of Sarcoidosis of the Gallbladder Wall
A Case of Sarcoidosis of the Gallbladder Wall Open
A 37-year-old man with pulmonary and hepatic sarcoidosis was hospitalized for right upper quadrant pain. Imaging showed a heterogeneous mass extending from the gallbladder, and biopsy confirmed sarcoidosis in the gallbladder wall, requirin…
View article: From Acute Infection to Prolonged Health Consequences: Understanding Health Disparities and Economic Implications in Long COVID Worldwide
From Acute Infection to Prolonged Health Consequences: Understanding Health Disparities and Economic Implications in Long COVID Worldwide Open
The COVID-19 pandemic has resulted in a growing number of patients experiencing persistent symptoms and physiological changes after recovering from acute SARS-CoV-2 infection, known as Long COVID. Long COVID is characterized by recurring s…
View article: Vaccination in the Era of Immunosuppression
Vaccination in the Era of Immunosuppression Open
Patients with autoimmune inflammatory rheumatic diseases (AIIRDs) are at increased risk for severe infections. Vaccine responses and safety profiles may differ between AIIRD patients and the general population. While patients with autoimmu…
View article: State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020
State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020 Open
The purpose of this cross-sectional study was to estimate the proportion of Arkansas residents who were infected with the SARS-CoV-2 virus between May and December 2020 and to assess the determinants of infection. To estimate seroprevalenc…
View article: Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas
Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas Open
Background The aim of this study was to estimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates in the small rural state of Arkansas, using SARS-CoV-2 antibody prevalence as an indicator of infection. Methods …
View article: Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic
Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic Open
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seroprevalence studies largely focus on adults, but little is known about spread in children. We determined SARS-CoV-2 seroprevalence in children and adolescents from …
View article: Pediatric SARS-CoV-2 seroprevalence in Arkansas over the first year of the COVID-19 pandemic
Pediatric SARS-CoV-2 seroprevalence in Arkansas over the first year of the COVID-19 pandemic Open
Background SARS-CoV-2 seroprevalence studies have largely focused on adults but little is known about spread in children. We determined SARS-CoV-2 seroprevalence in children and adolescents from Arkansas over the first year of the COVID-19…
View article: Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas
Temporal Variations in Seroprevalence of SARS-CoV-2 Infections by Race and Ethnicity in Arkansas Open
Objective Our objective is to estimate CoV-2 infection rates in a rural state using seroprevalence of antibodies to CoV-2 as an indicator of infection. Study Design and Setting This is a single-site study within an academic center and regi…
View article: A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance
A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance Open
Maternal obesity is correlated with cardiovascular disease in offspring, with a 1.3-fold increase in events observed in offspring of obese women. We have observed that obesity-exposed oocytes demonstrate impaired mitophagy and transmit dam…
View article: Maternal obesogenic diet induces endometrial hyperplasia, an early hallmark of endometrial cancer, in a diethylstilbestrol mouse model
Maternal obesogenic diet induces endometrial hyperplasia, an early hallmark of endometrial cancer, in a diethylstilbestrol mouse model Open
Thirty-eight percent of US adult women are obese, meaning that more children are now born of overweight and obese mothers, leading to an increase in predisposition to several adult onset diseases. To explore this phenomenon, we developed a…
View article: Obesity-exposed oocytes accumulate and transmit damaged mitochondria due to an inability to activate mitophagy
Obesity-exposed oocytes accumulate and transmit damaged mitochondria due to an inability to activate mitophagy Open
Mitochondria are the most prominent organelle in the oocyte. Somatic cells maintain a healthy population of mitochondria by degrading damaged mitochondria via mitophagy, a specialized autophagy pathway. However, evidence from previous work…
View article: Analyzing Molecular Pathways between Maternal Obesity and Risk of Endometrial Cancer in F1 Mice Generations
Analyzing Molecular Pathways between Maternal Obesity and Risk of Endometrial Cancer in F1 Mice Generations Open
From the Washington University Office of Undergraduate Research Digest (WUURD), Vol. 12, 05-01-2017. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College …