Zeeshan Fazal
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View article: Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B
Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B Open
View article: Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B
Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B Open
Testicular germ cell tumors (TGCTs) can be treated with cisplatin-based therapy. However, a clinically significant number of cisplatin-resistant patients die from progressive disease as no effective alternatives exist. Curative cisplatin t…
View article: Perfluorooctanesulfonic Acid Alters Pro-Cancer Phenotypes and Metabolic and Transcriptional Signatures in Testicular Germ Cell Tumors
Perfluorooctanesulfonic Acid Alters Pro-Cancer Phenotypes and Metabolic and Transcriptional Signatures in Testicular Germ Cell Tumors Open
The potential effects of poly- and perfluoroalkyl substances (PFAS) are a recently emergent human and environmental health concern. There is a consistent link between PFAS exposure and cancer, but the mechanisms are poorly understood. Alth…
View article: G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells
G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells Open
G0/G1 switch gene 2 (G0S2) is known to inhibit lipolysis by inhibiting adipose triglyceride lipase (ATGL). In this report, we dissect the role of G0S2 in ER+ versus ER- breast cancer. Overexpression of G0S2 in ER- cells increased cell prol…
View article: Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer
Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer Open
Poly- and perfluoroalkylated substances (PFAS) are chemicals that persist and bioaccumulate in the environment and are found in nearly all human populations through several routes of exposure. Human occupational and community exposure to P…
View article: Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factors
Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factors Open
Perfluorooctane sulfonate (PFOS) is a widespread persistent environmental pollutant implicated in nephrotoxicity with altered metabolism, carcinogenesis, and fibrosis potential. We studied the underlying epigenetic mechanism involving tran…
View article: Reciprocal epigenetic remodeling controls testicular cancer hypersensitivity to hypomethylating agents and chemotherapy
Reciprocal epigenetic remodeling controls testicular cancer hypersensitivity to hypomethylating agents and chemotherapy Open
Testicular germ cell tumors (TGCTs) are aggressive but sensitive to cisplatin‐based chemotherapy. Alternative therapies are needed for tumors refractory to cisplatin with hypomethylating agents providing one possibility. The mechanisms of …
View article: Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell Tumors
Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell Tumors Open
Compared to many common solid tumors, the main genetic drivers of most testicular germ cell tumors (TGCTs) are unknown. Decades of focus on genomic alterations in TGCTs including awareness of a near universal increase in copies of chromoso…
View article: Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours
Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours Open
Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT c…
View article: A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer
A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer Open
Purpose Germ cell tumors (GCTs) are cured with therapy based on cisplatin, although a clinically significant number of patients are refractory and die of progressive disease. Based on preclinical studies indicating that refractory testicul…
View article: Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours
Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours Open
Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT c…
View article: Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours
Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours Open
Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT c…
View article: Hypermethylation and global remodeling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumors
Hypermethylation and global remodeling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumors Open
Testicular germ cell tumors (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift toward DNA hypermethylation mediates cisplatin resistance in TGCT cel…
View article: Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors
Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors Open
A greater understanding of the hypersensitivity and curability of testicular germ cell tumors (TGCTs) has the potential to inform strategies to sensitize other solid tumors to conventional chemotherapies. The mechanisms of cisplatin hypers…
View article: Using Optimal F-Measure and Random Resampling in Gene Ontology Enrichment Calculations
Using Optimal F-Measure and Random Resampling in Gene Ontology Enrichment Calculations Open
Background: A central question in bioinformatics is how to minimize arbitrariness and bias in analysis of patterns of enrichment in data. A prime example of such a question is enrichment of gene ontology (GO) classes in lists of genes. Our…
View article: Mechanisms of cisplatin sensitivity and resistance in testicular germ cell tumors
Mechanisms of cisplatin sensitivity and resistance in testicular germ cell tumors Open
Testicular germ cell tumors (TGCTs) are a cancer pharmacology success story with a majority of patients cured even in the highly advanced and metastatic setting. Successful treatment of TGCTs is primarily due to the exquisite responsivenes…
View article: Introducing a Novel Method of Intravascular Adeno-associated Virus-mediated Gene Delivery.
Introducing a Novel Method of Intravascular Adeno-associated Virus-mediated Gene Delivery. Open
AAV-mediated gene delivery is an effective way to transduce cells intravascularly with a transgene of interest. Our method can be generalized across a wide variety of studies to further research or treat other vascular disease.
View article: Interaction in Business Discourse: A Comparative Study of the Journalistic Stance in Pakistani English Newspapers
Interaction in Business Discourse: A Comparative Study of the Journalistic Stance in Pakistani English Newspapers Open
The current study explores the authorial presence in the journalistic business discourse by comparing the use of two interactional features of hedges and boosters in the business news-reports and the business columns. The data comprised th…
View article: Using Optimal F-Measure and Random Resampling in Gene Ontology Enrichment Calculations
Using Optimal F-Measure and Random Resampling in Gene Ontology Enrichment Calculations Open
Background A central question in bioinformatics is how to minimize arbitrariness and bias in analysis of patterns of enrichment in data. A prime example of such a question is enrichment of gene ontology (GO) classes in lists of genes. Our …
View article: Towards a Unified Understanding of Lithium Action in Basic Biology and its Significance for Applied Biology
Towards a Unified Understanding of Lithium Action in Basic Biology and its Significance for Applied Biology Open
View article: Gene expression patterns of encapsulated microbial cells
Gene expression patterns of encapsulated microbial cells Open
To design hybrid cellular/synthetic devices such as sensors and vaccines, understanding of how the metabolic state of living cells changes upon physical confinement within three-dimensional matrices is vital. We analyze the gene expression…