Zhigang Zhang
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View article: Physiological Response and Transcriptome Analysis of Waxy Near-Isogenic Lines in Chinese Cabbage (Brassica rapa L. ssp. pekinensis) Under Drought Stress
Physiological Response and Transcriptome Analysis of Waxy Near-Isogenic Lines in Chinese Cabbage (Brassica rapa L. ssp. pekinensis) Under Drought Stress Open
To identify key genes involved in drought stress response among Chinese cabbage materials with different drought resistance, a pair of waxy near-isogenic lines (NILs) of Chinese cabbage were used as materials, and a 10% polyethylene glycol…
View article: Enhanced Agrobacterium-Mediated Transformation in Chinese Cabbage via Tenoxicam, Phytohormone Optimization, and Visual Reporters
Enhanced Agrobacterium-Mediated Transformation in Chinese Cabbage via Tenoxicam, Phytohormone Optimization, and Visual Reporters Open
Chinese cabbage (Brassica rapa ssp. pekinensis) is a globally important leafy vegetable, but its recalcitrance to Agrobacterium-mediated genetic transformation has severely limited functional genomics research. Here we demonstrate that bot…
View article: The Use of Proton Radiation in the Management of Adenoid Cystic Carcinoma
The Use of Proton Radiation in the Management of Adenoid Cystic Carcinoma Open
View article: Luminescence dating reveals late Quaternary evolution of the Pearl River Delta estuary (China) in response to global climate and sea-level changes
Luminescence dating reveals late Quaternary evolution of the Pearl River Delta estuary (China) in response to global climate and sea-level changes Open
View article: Pathogenicity of Tolypocladium spp. Against Plutella xylostella: Effects on Immune Enzyme Activities and Gene Expression Profile
Pathogenicity of Tolypocladium spp. Against Plutella xylostella: Effects on Immune Enzyme Activities and Gene Expression Profile Open
(1) Background: Tolypocladium spp. are fungi known for producing cyclosporin A and their ability to infect insects. However, their pathogenicity against the lepidopteran pest Plutella xylostella has not been previously reported. (2) Method…
View article: The influencing factors of neonatal extubation failure: A systematic review and meta-analysis
The influencing factors of neonatal extubation failure: A systematic review and meta-analysis Open
We identified 20 factors associated with an increased risk of extubation failure, which can help medical staff in the early identification of children with high risk of extubation failure and thereby take measures. Future studies could dev…
View article: Prospective Evaluation of a Novel Unidirectional Permanent Device for Intraoperative Brachytherapy
Prospective Evaluation of a Novel Unidirectional Permanent Device for Intraoperative Brachytherapy Open
View article: Comparison of surgical and radiotherapy outcomes in octogenarians with early-stage non-small cell lung cancer: a SEER database retrospective cohort study
Comparison of surgical and radiotherapy outcomes in octogenarians with early-stage non-small cell lung cancer: a SEER database retrospective cohort study Open
View article: Spatiotemporal glacier retreat on the Tibetan Plateau since the LGMG to early holocene based on compilation of moraine boulder ages
Spatiotemporal glacier retreat on the Tibetan Plateau since the LGMG to early holocene based on compilation of moraine boulder ages Open
Tibetan Plateau and its surrounding mountains (TPSM) have experienced prominent glacier retreat since the Global Last Glacial Maximum, while the detailed deglaciation process remains unclear. To investigate the spatiotemporal pattern of th…
View article: Mechanistic Insights into Microbial-Mediated Transformation of Fe²⁺, Mn²⁺, and Nh₄⁺ Under Co-Existing Conditions in Groundwater: Evidence from Two-Dimensional Tank Experiment
Mechanistic Insights into Microbial-Mediated Transformation of Fe²⁺, Mn²⁺, and Nh₄⁺ Under Co-Existing Conditions in Groundwater: Evidence from Two-Dimensional Tank Experiment Open
View article: Bone Marrow Mesenchymal Stem Cells Inhibit Ferroptosis Through Mitochondrial Transfer and Improve Endothelial Cell Dysfunction
Bone Marrow Mesenchymal Stem Cells Inhibit Ferroptosis Through Mitochondrial Transfer and Improve Endothelial Cell Dysfunction Open
View article: 2′3′-cGAMP interactome identifies 2′3′-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity
2′3′-cGAMP interactome identifies 2′3′-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity Open
c-di-GAMP was first identified in bacteria to promote colonization, while mammalian 2′3′-cGAMP is synthesized by cGAS to activate STING for innate immune stimulation. However, 2′3′-cGAMP function beyond innate immunity remains elusive. Her…
View article: SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1 Open
Selective serotonin reuptake inhibitors (SSRIs) have shown promise in cancer therapy, particularly for hepatocellular carcinoma (HCC), but their molecular targets and mechanisms remain unclear. Here, we show that SSRIs exhibit significant …
View article: Clinical profiles and molecular genetic analyses of 98 Chinese children with short statures
Clinical profiles and molecular genetic analyses of 98 Chinese children with short statures Open
Background Short stature is one of the most prevalent endocrine disorders in children, and its genetic basis is a complex and actively researched subject. Currently, there is limited genetic research on exome sequencing for short stature, …
View article: Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies
Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies Open
Our study demonstrates that chronic inorganic arsenic exposure evokes liver-microbiota-gut axis disruption in chickens and establishes a scientific basis for evaluating health risk induced by environmental pollutant arsenic.
View article: The Impact of Marine Oil Spills on the Ecosystem
The Impact of Marine Oil Spills on the Ecosystem Open
This study delves into the significant impact of marine oil spills on ecosystems, societies, and economies. Marine environments, critical for global biodiversity, face severe threats from incidents like oil spills, causing immediate enviro…
View article: Comparative Analysis of Efficiency and Environmental Impact of Various Marine Oil Cleanup Technologies
Comparative Analysis of Efficiency and Environmental Impact of Various Marine Oil Cleanup Technologies Open
Marine oil pollution, stemming from human activities, poses severe threats to ecosystems and coastal areas globally. This study assesses and compares various marine oil cleanup technologies, examining their efficiency and environmental imp…
View article: 四川甘孜州措普湖沉积物微量元素记录的近200年环境变化
四川甘孜州措普湖沉积物微量元素记录的近200年环境变化 Open
摘要: 青藏高原东缘分布的小型湖泊由于其特殊的地理位置,受人类活动影响较小,其沉积记录对气候环境变化的响应具有区域性意义,特别在恢复短时间尺度气候及区域沉积环境方面有着独特的优势,然而目前鲜有研究涉及.对四川省甘孜州措普湖湖心45 cm的沉积岩心样品进行了微量元素地球化学分析,重建了当地过去近200年中的气候演变过程.结果表明:近200年来,沉积岩心中稀土元素具有基本相同的垂向变化趋势,均在1841—1920年的小冰期时保持低值,在1890年左右受地震间接影响达到最低值,之…
View article: Stereotactic Body Radiation Therapy for Stage IIA to IIIA Inoperable Non-Small Cell Lung Cancer: A Phase 1 Dose-Escalation Trial
Stereotactic Body Radiation Therapy for Stage IIA to IIIA Inoperable Non-Small Cell Lung Cancer: A Phase 1 Dose-Escalation Trial Open
View article: Design and R&D of megawatt lithium-cooled space nuclear reactor
Design and R&D of megawatt lithium-cooled space nuclear reactor Open
Space nuclear reactor power, with the advantages of high energy density, high output power, long duration, and minimal influence from the external environment, is the preferred route for energy supply for future high-power long-life space …
View article: The complete genome sequence of <i>Pantoea agglomerans</i> NBBC-01, isolated from rot potato tubers
The complete genome sequence of <i>Pantoea agglomerans</i> NBBC-01, isolated from rot potato tubers Open
The Gram-negative bacterium Pantoea agglomerans has been isolated from various habitats including disease plants. Here, we present the genome of P. agglomerans strain NBBC-01 obtained from rotten potatoes that were infected by Ditylenchus …
View article: Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism
Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism Open
Ulcerative colitis (UC) has been confirmed as a disease with a high incidence and low cure rate worldwide. In severe cases, UC can develop into colon cancer. Modern research has confirmed that berberine (BBR) can treat UC by inhibiting the…
View article: [Therapeutic mechanism of <i>Guizhi Gancao</i> Decoction for heart failure: a network pharmacology-based analysis].
[Therapeutic mechanism of <i>Guizhi Gancao</i> Decoction for heart failure: a network pharmacology-based analysis]. Open
The therapeutic mechanism of GZGCD for HF involves multiple targets including PRKCA, PRKCB, MAPK1, MAPK3, and MAPK8 and multiple pathways including the regulatory pathway in cancer and the calcium signaling pathway.
View article: Development of VHL-recruiting STING PROTACs that suppress innate immunity
Development of VHL-recruiting STING PROTACs that suppress innate immunity Open
View article: [A prospective randomized controlled study of antibiotic bone cement in the treatment of diabetic foot ulcer].
[A prospective randomized controlled study of antibiotic bone cement in the treatment of diabetic foot ulcer]. Open
Objective: To investigate the clinical effects and related mechanism of antibiotic bone cement in treating diabetic foot ulcer (DFU). Methods: A prospective randomized controlled study was conducted. From August 2020 to Augus…
View article: The SUMOylation of Human Cytomegalovirus Capsid Assembly Protein Precursor (UL80.5) Affects Its Interaction with Major Capsid Protein (UL86) and Viral Replication
The SUMOylation of Human Cytomegalovirus Capsid Assembly Protein Precursor (UL80.5) Affects Its Interaction with Major Capsid Protein (UL86) and Viral Replication Open
Human Cytomegalovirus Capsid Assembly Protein Precursor (pAP, UL80.5) plays a key role in capsid assembly by forming an internal protein scaffold with Major Capsid Protein (MCP, UL86) and other capsid subunits. In this study, we revealed U…
View article: Vertical variations in microbial diversity, composition, and interactions in freshwater lake sediments on the Tibetan plateau
Vertical variations in microbial diversity, composition, and interactions in freshwater lake sediments on the Tibetan plateau Open
Microbial communities in freshwater lake sediments exhibit a distinct depth-dependent variability. Further exploration is required to understand their biodiversity pattern and microbial interactions in vertical sediments. In this study, se…
View article: Secondary Metabolites from Aspergillus sparsus NBERC_28952 and Their Herbicidal Activities
Secondary Metabolites from Aspergillus sparsus NBERC_28952 and Their Herbicidal Activities Open
Fungi have been used in the production of a wide range of biologically active metabolites, including potent herbicides. In the search for pesticides of natural origin, Aspergillus sparsus NBERC_28952, a fungal strain with herbicidal activi…
View article: Identification of COR413 Gene Family in Peach and Its Expression in Low Temperature and LTC Treatment at Postharvest
Identification of COR413 Gene Family in Peach and Its Expression in Low Temperature and LTC Treatment at Postharvest Open
Peach were susceptible to chilling injury during low temperature (0 o C) storage at postharvest, and LTC (Low temperature conditioning) treatment could reduce chilling injury such as of H 2 O 2 production and fruit browning. In order to s…
View article: Agroactive volatile organic compounds from microbes: Chemical diversities and potentials of application in crop protection
Agroactive volatile organic compounds from microbes: Chemical diversities and potentials of application in crop protection Open
Synthetic chemicals have been widely used in modern agriculture as fertilizer, plant growth regulators and pesticides. Although the chemical inputs improved the crop production, it is well known about their negative effects, such as enviro…