Zehra Jamil
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View article: Patterns and association between smokeless tobacco consumption and hemoglobin level among 6 to 12 years children: analytical cross-sectional study
Patterns and association between smokeless tobacco consumption and hemoglobin level among 6 to 12 years children: analytical cross-sectional study Open
SLT users had lower hemoglobin levels, although the results were not statistically significant. Overall, children have lower hemoglobin levels, and most of them used SLT for the first time before age 6 or between ages 7 and 8, which is a m…
View article: Host-microbiome determinants of ready-to-use supplemental food efficacy in acute childhood malnutrition
Host-microbiome determinants of ready-to-use supplemental food efficacy in acute childhood malnutrition Open
Ready-to-use supplemental foods (RUSF) are energy-dense meals formulated to prevent and treat moderate and severe childhood acute malnutrition (MAM and SAM) in high-risk settings. Although lifesaving, the degree and durability of weight re…
View article: The pesticide paradox: Metabolomics insights into N-Methyl-2-pyrrolidone (NMP) exposure as a culprit of infant undernourishment
The pesticide paradox: Metabolomics insights into N-Methyl-2-pyrrolidone (NMP) exposure as a culprit of infant undernourishment Open
View article: Enhancing student engagement in anatomy by integrating technology to modify a practical exam
Enhancing student engagement in anatomy by integrating technology to modify a practical exam Open
View article: Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children
Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children Open
This scoring system involving 5 histologic parameters demonstrates very high discrimination between EED and normal biopsies, indicating that this scoring system can be applied with confidence to studies of intestinal biopsies in EED.
View article: Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study
Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study Open
This study contributes a crucial negative finding that duodenal morphological features did not associate with anthropometric phenotypes; hence, anthropometric measurements may not be a suitable outcome measure for use in EED trials. Trial …
View article: Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction
Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction Open
Our results support a model of chronic epithelial stress that decreases epithelial differentiation and absorptive function. The close association of several IHC parameters with manual histologic scoring suggests that automated digital quan…
View article: Nutrient dataset development via FAO/INFOODS approach for infant nutritional survey in rural Matiari, Pakistan
Nutrient dataset development via FAO/INFOODS approach for infant nutritional survey in rural Matiari, Pakistan Open
To accurately evaluate dietary intake, multiple resources are necessary, including serving-size modules, pictures, and questionnaires that are used to gather information during surveys. One critical component is the accessibility of food c…
View article: A shared group of bacterial taxa in the duodenal microbiota of undernourished Pakistani children with environmental enteric dysfunction
A shared group of bacterial taxa in the duodenal microbiota of undernourished Pakistani children with environmental enteric dysfunction Open
Environmental enteric dysfunction (EED) is a subclinical syndrome of altered small intestinal function postulated to be an important contributor to childhood undernutrition. The role of small intestinal bacterial communities in the pathoph…
View article: Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis
Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multicountry analysis Open
Morphometric analysis of duodenal biopsy slides across geographies identified morphologic features of EED, specifically short villi, elongated crypts, and a smaller V:C ratio relative to NPA slides, although not as severe as in celiac slid…
View article: Impact of diarrhoea and acute respiratory infection on environmental enteric dysfunction and growth of malnourished children in Pakistan: a longitudinal cohort study
Impact of diarrhoea and acute respiratory infection on environmental enteric dysfunction and growth of malnourished children in Pakistan: a longitudinal cohort study Open
Bill and Melinda Gates Foundation and The National Institutes of Health.
View article: Quantitative Morphometry and Machine Learning Model to Explore Duodenal and Rectal Mucosal Tissue of Children with Environmental Enteric Dysfunction
Quantitative Morphometry and Machine Learning Model to Explore Duodenal and Rectal Mucosal Tissue of Children with Environmental Enteric Dysfunction Open
Environmental enteric dysfunction (EED) is a subclinical enteropathy prevalent in resource-limited settings, hypothesized to be a consequence of chronic exposure to environmental enteropathogens, resulting in malnutrition, growth failure, …
View article: Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy
Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy Open
View article: Association of Anti-Rotavirus IgA Seroconversion with Growth, Environmental Enteric Dysfunction and Enteropathogens in Rural Pakistani Infants
Association of Anti-Rotavirus IgA Seroconversion with Growth, Environmental Enteric Dysfunction and Enteropathogens in Rural Pakistani Infants Open
View article: Implementation challenges from a prospective, interventional biopsy-based study of Environmental Enteropathy in rural Pakistan
Implementation challenges from a prospective, interventional biopsy-based study of Environmental Enteropathy in rural Pakistan Open
The Study of Environmental Enteropathy (EE) and Malnutrition in Pakistan (SEEM) is a community intervention trial designed to understand the pathophysiology of EE and its associated clinical phenotypes in children less than two years of ag…
View article: Gut integrity and duodenal enteropathogen burden in undernourished children with environmental enteric dysfunction
Gut integrity and duodenal enteropathogen burden in undernourished children with environmental enteric dysfunction Open
Environmental enteric dysfunction (EED) is a subclinical condition of intestinal inflammation, barrier dysfunction and malabsorption associated with growth faltering in children living in poverty. This study explores association of altered…
View article: Implementation challenges from a prospective, interventional biopsy-based study of Environmental Enteropathy in rural Pakistan
Implementation challenges from a prospective, interventional biopsy-based study of Environmental Enteropathy in rural Pakistan Open
The Study of Environmental Enteropathy (EE) and Malnutrition in Pakistan (SEEM) is a community intervention trial designed to understand the pathophysiology of EE and its associated clinical phenotypes in children less than two years of ag…
View article: Pathobiome driven gut inflammation in Pakistani children with Environmental Enteric Dysfunction
Pathobiome driven gut inflammation in Pakistani children with Environmental Enteric Dysfunction Open
Environmental Enteric Dysfunction (EED) is an acquired small intestinal inflammatory condition underlying high rates of stunting in children <5 years of age in low- and middle-income countries. Children with EED are known to have repeated …
View article: Blended learning: call of the day for medical education in the global South
Blended learning: call of the day for medical education in the global South Open
Blended learning (BL) is an e-learning approach that combines the strengths of both online and face-to-face learning, creating meaningful interactions between students, teachers, and resources. This paper explores students’ expectations an…
View article: Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia
Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia Open
Low AMH levels may lead to hypertension in pregnancy suggesting a role in detecting vascular diseases as well as its effect on ovarian aging. However, further research is required to establish a causal relationship.
View article: The role of microbiome in preterm labor: Recent advances and future challenges
The role of microbiome in preterm labor: Recent advances and future challenges Open
Background: Our current understanding of preterm labor is limited in the context of dysbiosis of microbiome. Human microbiome is comprised of trillions of microorganisms, residing on and within our bodies that are associated with the vital…
View article: Life Style Practices And Health Risk Behaviors Of Medical Students: A Cross Sectional Study
Life Style Practices And Health Risk Behaviors Of Medical Students: A Cross Sectional Study Open
Objective: A health risk behavior like physical inactivity, unhealthy diet, tobacco use, drug abuse, unprotected sexual practices or harmful use of alcohol is linked with serious ailments like liver cirrhosis, hypertension, abnormal lipid …
View article: Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques
Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques Open
Leptin-Kisspeptin-fertility link is expressed by maximum number of clinical pregnancies in the female group that showed strongest relationship between serum Leptin and Kisspeptin levels, irrespective of their BMI.
View article: Kisspeptin, unexplained infertility and embryo implantation
Kisspeptin, unexplained infertility and embryo implantation Open
The primary objective of the study was to compare baseline KP levels in females with different causes of infertility and then correlate it with the risk of failure to conceive, preclinical abortion and pregnancy after intracytoplasmic sper…
View article: Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation.
Kisspeptin: A Potential Factor for Unexplained Infertility and Impaired Embryo Implantation. Open
Deficiency of KP in females with unexplained infertility was associated with reduced chances of implantation after ICSI.
View article: Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study
Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study Open
Aim: To assess circulatory levels of interleukin-18 (IL-18) and determine whether the presence of IL-18 promoter polymorphism influences metabolic syndrome phenotypes.Methods: This study recruited one hundred and eighty individuals divided…
View article: Anti Mullerian Hormone: Ovarian response indicator in young patients receiving Long GnRH Agonist Protocol for Ovarian Stimulation
Anti Mullerian Hormone: Ovarian response indicator in young patients receiving Long GnRH Agonist Protocol for Ovarian Stimulation Open
Our study reaffirms that serum AMH correlates well with oocytes retrieved, particularly in females younger than 35 years. We suggest incorporation of AMH in baseline assessment of infertile females, who are falsely advised to postpone inte…
View article: Anti-Mullerian Hormone:<i>Above and Beyond Conventional Ovarian Reserve Markers</i>
Anti-Mullerian Hormone:<i>Above and Beyond Conventional Ovarian Reserve Markers</i> Open
Management of ovarian dysfunctions requires accurate estimation of ovarian reserve (OR). Therefore, reproductive hormones and antral follicle count (AFC) are assessed to indicate OR. Serum anti-Mullerian hormone (AMH) is a unique biomarker…
View article: Assessment of ovarian reserve: Anti-Mullerian hormone versus follicle stimulating hormone
Assessment of ovarian reserve: Anti-Mullerian hormone versus follicle stimulating hormone Open
Background: This study aimed to evaluate the strength of anti-Mullerian hormone (AMH) and follicle stimulating hormone (FSH) in reflecting the antral follicle count (AFC) in infertile females. Materials and Methods: This cross-sectional st…
View article: Silent Mutation in KISS1 and KISS1R and Unexplained Infertility
Silent Mutation in KISS1 and KISS1R and Unexplained Infertility Open
Kisspeptin (KP) is a set of peptides coded by the KISS1 gene that is a metastasis suppressor gene located on chromosome 1q32. It plays an important role in regulation of hypothalamic-pituitary-gonadal axis (1). The association of KP with t…