Zejuan Li
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View article: Thor: a platform for cell-level investigation of spatial transcriptomics and histology
Thor: a platform for cell-level investigation of spatial transcriptomics and histology Open
Spatial transcriptomics links gene expression with tissue morphology, however, current tools often prioritize genomic analysis, lacking integrated image interpretation. To address this, we present Thor, a comprehensive platform for cell-le…
View article: Impact of Long-Term Plasma Storage on Cell-Free DNA Epigenetic Biomarker Studies
Impact of Long-Term Plasma Storage on Cell-Free DNA Epigenetic Biomarker Studies Open
Impact of long-term plasma storage on biomarker analysis is critical for ensuring data reliability. Cell-free DNA (cfDNA) epigenetic markers, including 5-hydroxymethylcytosine (5hmC), have emerged for disease detection, prognosis, and trea…
View article: 5-Hydroxymethylcytosine in Cell-Free DNA Predicts Immunotherapy Response in Lung Cancer
5-Hydroxymethylcytosine in Cell-Free DNA Predicts Immunotherapy Response in Lung Cancer Open
Immune checkpoint inhibitors (ICIs) drastically improve therapeutic outcomes for lung cancer, but accurately predicting individual patient responses to ICIs remains a challenge. We performed the genome-wide profiling of 5-hydroxymethylcyto…
View article: Cell-Free DNA 5-Hydroxymethylcytosine Signatures for Lung Cancer Prognosis
Cell-Free DNA 5-Hydroxymethylcytosine Signatures for Lung Cancer Prognosis Open
Accurate prognostic markers are essential for guiding effective lung cancer treatment strategies. The level of 5-hydroxymethylcytosine (5hmC) in tissue is independently associated with overall survival (OS) in lung cancer patients. We expl…
View article: Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia
Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia Open
View article: TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal Open
View article: Classification of Acute Myeloid Leukemia by Cell-Free DNA 5-Hydroxymethylcytosine
Classification of Acute Myeloid Leukemia by Cell-Free DNA 5-Hydroxymethylcytosine Open
Epigenetic abnormality is a hallmark of acute myeloid leukemia (AML), and aberrant 5-hydroxymethylcytosine (5hmC) levels are commonly observed in AML patients. As epigenetic subgroups of AML correlate with different clinical outcomes, we i…
View article: Supplemental Methods and References from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Methods and References from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
Description of additional methods and procedures used in the study. Also includes Supplemental References.
View article: Supplemental Table 1 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Supplemental Table 1 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Clinical and molecular characteristics of the AML patients in GSE37642 cohort
View article: Supplemental Figures from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Supplemental Figures from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Supplemental Figure 1. Construction of G7-FLT3L dendrimers and their uptake ratio in AML cells. Supplemental Figure 2. G7 PAMAM dendrimers efficiently complex small, single stranded oligonucleotides. Supplemental Figure 3. G7-FLT3L-miR-150…
View article: Supplemental Table S2 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Table S2 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
List of the 1,022 genes that are expressed at a significantly lower level in Group 1 than in both Groups 2 and 3.
View article: Supplemental Figures S1-S11 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Figures S1-S11 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
Flow cytometry analysis of leukemic bone marrow cells from recipient mice of primary BM transplantation (S1); Comparison of leukemic latency between secondary BMT recipient mice transplanted with primary leukemic BM cells from two donor mi…
View article: Supplemental Table S2 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Table S2 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
List of the 1,022 genes that are expressed at a significantly lower level in Group 1 than in both Groups 2 and 3.
View article: Supplemental Table 2 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Supplemental Table 2 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Effects of the nanoparticles on mouse blood cell differentiation two (A) or four (B) weeks after the last administration of nanoparticles or control (PBS)
View article: Data from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Data from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
Overexpression of HOXA/MEIS1/PBX3 homeobox genes is the hallmark of mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML). HOXA9 and MEIS1 are considered to be the most critical targets of MLL fus…
View article: Supplemental Table S1 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Table S1 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
List of the 1,190 genes that are expressed at a significantly higher level in Group 1 than in both Groups 2 and 3.
View article: Supplemental Table 1 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Supplemental Table 1 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Clinical and molecular characteristics of the AML patients in GSE37642 cohort
View article: Supplementary Tables 1-4 from Consistent Deregulation of Gene Expression between Human and Murine <i>MLL</i> Rearrangement Leukemias
Supplementary Tables 1-4 from Consistent Deregulation of Gene Expression between Human and Murine <i>MLL</i> Rearrangement Leukemias Open
Supplementary Tables 1-4 from Consistent Deregulation of Gene Expression between Human and Murine MLL Rearrangement Leukemias
View article: Supplemental Table S3 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Table S3 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
Distribution of target genes of MLL-fusion proteins in different sets of genes that are significantly differentially expressed between the three groups of samples.
View article: Supplemental Figure Legends from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Figure Legends from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
Legends for Supplemental Figures S1-S11.
View article: Supplemental Table 3 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Supplemental Table 3 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Effects of JQ1 and/or miR-150 nanoparticles on mouse blood cell differentiation four weeks after the last administration of drugs or control (PBS)
View article: Supplemental Table 2 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Supplemental Table 2 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Effects of the nanoparticles on mouse blood cell differentiation two (A) or four (B) weeks after the last administration of nanoparticles or control (PBS)
View article: Supplementary Figure Legends from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Supplementary Figure Legends from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Legends for supplemental figures.
View article: Supplemental Table S3 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Table S3 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
Distribution of target genes of MLL-fusion proteins in different sets of genes that are significantly differentially expressed between the three groups of samples.
View article: Supplemental Figures S1-S11 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease
Supplemental Figures S1-S11 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease Open
Flow cytometry analysis of leukemic bone marrow cells from recipient mice of primary BM transplantation (S1); Comparison of leukemic latency between secondary BMT recipient mice transplanted with primary leukemic BM cells from two donor mi…
View article: Data from Consistent Deregulation of Gene Expression between Human and Murine <i>MLL</i> Rearrangement Leukemias
Data from Consistent Deregulation of Gene Expression between Human and Murine <i>MLL</i> Rearrangement Leukemias Open
Important biological and pathologic properties are often conserved across species. Although several mouse leukemia models have been well established, the genes deregulated in both human and murine leukemia cells have not been studied syste…
View article: Supplemental Table 3 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Supplemental Table 3 from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Effects of JQ1 and/or miR-150 nanoparticles on mouse blood cell differentiation four weeks after the last administration of drugs or control (PBS)
View article: Data from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles
Data from Eradication of Acute Myeloid Leukemia with FLT3 Ligand–Targeted miR-150 Nanoparticles Open
Acute myeloid leukemia (AML) is a common and fatal form of hematopoietic malignancy. Overexpression and/or mutations of FLT3 have been shown to occur in the majority of cases of AML. Our analysis of a large-scale AML patient cohort …
View article: Supplementary Tables 1-4 from Consistent Deregulation of Gene Expression between Human and Murine <i>MLL</i> Rearrangement Leukemias
Supplementary Tables 1-4 from Consistent Deregulation of Gene Expression between Human and Murine <i>MLL</i> Rearrangement Leukemias Open
Supplementary Tables 1-4 from Consistent Deregulation of Gene Expression between Human and Murine MLL Rearrangement Leukemias
View article: Data from Consistent Deregulation of Gene Expression between Human and Murine <i>MLL</i> Rearrangement Leukemias
Data from Consistent Deregulation of Gene Expression between Human and Murine <i>MLL</i> Rearrangement Leukemias Open
Important biological and pathologic properties are often conserved across species. Although several mouse leukemia models have been well established, the genes deregulated in both human and murine leukemia cells have not been studied syste…