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View article: 1314 First-in-human evaluation of HF50, a novel liposomal HER2×CD3 T cell engager with TLR agonist payload, demonstrates tolerability and early clinical response
1314 First-in-human evaluation of HF50, a novel liposomal HER2×CD3 T cell engager with TLR agonist payload, demonstrates tolerability and early clinical response Open
View article: [Interpretation and Examples: Key Updates in CONSORT 2025].
[Interpretation and Examples: Key Updates in CONSORT 2025]. Open
Standardized clinical trial reporting is crucial for ensuring the scientific validity, reproducibility, and clinical translational value of reported results. The Consolidated Standards of Reporting Trials (CONSORT) statement, an internatio…
View article: [Interpretation and Examples: Key Updates in SPIRIT 2025 Statement].
[Interpretation and Examples: Key Updates in SPIRIT 2025 Statement]. Open
A high-quality clinical trial protocol is the cornerstone for ensuring the scientific integrity and ethical compliance of a study. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) has become the international…
View article: Efficacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cell carcinoma: a phase II trial
Efficacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cell carcinoma: a phase II trial Open
The clinical activity of neoadjuvant immunochemotherapy (NAIC) for treating locally advanced oral squamous cell carcinoma (LA-OSCC) remains uncertain. This single-arm, phase II trial (ChiCTR2200066119) tested 2 cycles of NAIC with camreliz…
View article: FOLR1 enhances the radioresistance of gastric cancer via the rescue of damaged DNA
FOLR1 enhances the radioresistance of gastric cancer via the rescue of damaged DNA Open
Gastric cancer (GC) is a multifactorial malignancy with high incidence and mortality rates worldwide. Radiotherapy plays a crucial role in the comprehensive treatment of GC patients; however, its clinical benefits are still limited due to …
View article: Correction: Guidelines, Consensus Statements, and Standards for the Use of Artificial Intelligence in Medicine: Systematic Review
Correction: Guidelines, Consensus Statements, and Standards for the Use of Artificial Intelligence in Medicine: Systematic Review Open
[This corrects the article DOI: 10.2196/46089.].
View article: Individualized 3D-printed bolus promotes precise postmastectomy radiotherapy in patients receiving breast reconstruction
Individualized 3D-printed bolus promotes precise postmastectomy radiotherapy in patients receiving breast reconstruction Open
Purpose To evaluate the efficacy and safety of 3D-printed tissue compensations in breast cancer patients receiving breast reconstruction and postmastectomy radiotherapy (PMRT). Methods and materials We enrolled patients with breast cancer …
View article: Guidelines, Consensus Statements, and Standards for the Use of Artificial Intelligence in Medicine: Systematic Review
Guidelines, Consensus Statements, and Standards for the Use of Artificial Intelligence in Medicine: Systematic Review Open
Background The application of artificial intelligence (AI) in the delivery of health care is a promising area, and guidelines, consensus statements, and standards on AI regarding various topics have been developed. Objective We performed t…
View article: Anti-PD-1/PD-L1 for nasopharyngeal carcinoma: a comprehensive analysis of registered trials on ClinicalTrials.gov
Anti-PD-1/PD-L1 for nasopharyngeal carcinoma: a comprehensive analysis of registered trials on ClinicalTrials.gov Open
Objective: Clinical trials play an important role in the development of healthcare. However, the current status of clinical trials on anti-PD-1/PD-L1 for nasopharyngeal carcinoma remains unclear. Therefore, this study aims to provide a com…
View article: Factors influencing the quality of acupuncture clinical trials: a qualitative interview of stakeholders
Factors influencing the quality of acupuncture clinical trials: a qualitative interview of stakeholders Open
View article: The disparities in prognostic prediction and annualized hazard function in different molecular subtypes between young Chinese and White American women with breast cancer
The disparities in prognostic prediction and annualized hazard function in different molecular subtypes between young Chinese and White American women with breast cancer Open
Background and objectives The prognostic disparities in different molecular subtypes between young Chinese and White American breast cancer patients remain unclear. The goal of this study was to explore the prognostic differences in differ…
View article: Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study
Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study Open
Background Young breast cancer patients are more likely to develop aggressive tumor characteristics and a worse prognosis than older women, and different races and ethnicities have distinct epidemiologies and prognoses. However, few studie…
View article: Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study (Preprint)
Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study (Preprint) Open
BACKGROUND Young breast cancer patients are more likely to develop aggressive tumor characteristics and a worse prognosis than older women, and different races and ethnicities have distinct epidemiologies and prognoses. However, few studi…
View article: Guidelines, Consensus Statements, and Standards for the Use of Artificial Intelligence in Medicine: Systematic Review (Preprint)
Guidelines, Consensus Statements, and Standards for the Use of Artificial Intelligence in Medicine: Systematic Review (Preprint) Open
BACKGROUND The application of artificial intelligence (AI) in the delivery of health care is a promising area, and guidelines, consensus statements, and standards on AI regarding various topics have been developed. OBJECTIVE We performe…
View article: The prognostic differences and the effect of postmastectomy radiotherapy between post‐chemotherapy <scp>ypT1‐2ypN1</scp> and de novo <scp>pT1‐2N1</scp> breast cancer
The prognostic differences and the effect of postmastectomy radiotherapy between post‐chemotherapy <span>ypT1‐2ypN1</span> and de novo <span>pT1‐2N1</span> breast cancer Open
Background The prognosis and the value of postmastectomy radiotherapy (PMRT) between post‐chemotherapy ypT1‐2ypN1 and de novo pT1‐2N1 breast cancer (BC) remain controversial. We aimed to evaluate the prognostic differences and the effect o…
View article: Clinical Application of Traditional Chinese Medicine Therapy for Type 2 Diabetes Mellitus: An Evidence Map
Clinical Application of Traditional Chinese Medicine Therapy for Type 2 Diabetes Mellitus: An Evidence Map Open
Type 2 diabetes mellitus (T2DM), a common disease with a complex etiology in the world, is an important risk factor for severe cardiovascular and cerebrovascular diseases. However, treatments of T2DM are mainly based on Western medicine, w…