Zeliang Ma
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View article: Comorbidity patterns and mortality in HFpEF: A retrospective longitudinal cohort study
Comorbidity patterns and mortality in HFpEF: A retrospective longitudinal cohort study Open
View article: An MRI-based model for preoperative prediction of tertiary lymphoid structures in patients with gallbladder cancer
An MRI-based model for preoperative prediction of tertiary lymphoid structures in patients with gallbladder cancer Open
View article: Postoperative radiotherapy enhances survival in NSCLC patients with moderate lymph node metastases following surgery: A SEER-based population cohort study
Postoperative radiotherapy enhances survival in NSCLC patients with moderate lymph node metastases following surgery: A SEER-based population cohort study Open
The role of postoperative radiotherapy (PORT) for non-small cell lung cancer (NSCLC) is still debated. A nonlinear relationship may exist between the number of positive lymph nodes (PLN) and the benefits of PORT. Our study seeks to identif…
View article: Recent advances and challenges in colorectal cancer: From molecular research to treatment
Recent advances and challenges in colorectal cancer: From molecular research to treatment Open
Colorectal cancer (CRC) ranks among the top causes of cancer-related fatalities globally. Recent progress in genomics, proteomics, and bioinformatics has greatly improved our comprehension of the molecular underpinnings of CRC, paving the …
View article: Postoperative radiotherapy improves disease-free survival of EGFR wild-type pN2 non-squamous-cell non-small-cell lung cancer (Nsq-NSCLC) patients after complete resection: a propensity score matching analysis
Postoperative radiotherapy improves disease-free survival of EGFR wild-type pN2 non-squamous-cell non-small-cell lung cancer (Nsq-NSCLC) patients after complete resection: a propensity score matching analysis Open
For patients with completely resected pN2 Nsq-NSCLC receiving adjuvant chemotherapy, PORT may improve DFS in EGFRwt patients but not in EGFRm patients. Randomized clinical trials are needed for validation.
View article: Efficacy and safety of atezolizumab–bevacizumab vs pembrolizumab-lenvatinib in unresectable hepatocellular carcinoma: a retrospective, cohort study
Efficacy and safety of atezolizumab–bevacizumab vs pembrolizumab-lenvatinib in unresectable hepatocellular carcinoma: a retrospective, cohort study Open
Background The relative superiority of atezolizumab–bevacizumab versus pembrolizumab-lenvatinib in treatment of unresectable hepatocellular carcinoma (HCC) remains uncertain. This study aims to compare the efficacy of atezolizumab–bevacizu…
View article: Multimodality deep learning radiomics predicts pathological response after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma
Multimodality deep learning radiomics predicts pathological response after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma Open
View article: Heterogeneity in peripheral blood immune lymphocyte subsets predicts the response of immunotherapy or chemoradiotherapy in advanced lung cancer: an analysis across different pathological types, treatment modalities and age
Heterogeneity in peripheral blood immune lymphocyte subsets predicts the response of immunotherapy or chemoradiotherapy in advanced lung cancer: an analysis across different pathological types, treatment modalities and age Open
Background The shaping of the tumor immune microenvironment does not only rely on tumor-infiltrating lymphocytes but on the recruitment of lymphocytes in peripheral blood. Monitoring peripheral blood lymphocyte subsets level (PBLSL) can pr…
View article: Higher immune cell radiation dose is correlated with poor tumor control and survival in patients with non-small cell lung cancer receiving postoperative radiotherapy
Higher immune cell radiation dose is correlated with poor tumor control and survival in patients with non-small cell lung cancer receiving postoperative radiotherapy Open
EDRIC is an independent prognostic factor for survival in patients with NSCLC undergoing PORT. Higher doses of radiation to the immune system are associated with tumor progression and poor survival. Organs at risk for the immune system sho…
View article: Integrating MR radiomics and dynamic hematological factors predicts pathological response to neoadjuvant chemoradiotherapy in esophageal cancer
Integrating MR radiomics and dynamic hematological factors predicts pathological response to neoadjuvant chemoradiotherapy in esophageal cancer Open
An integrated model using dynamic hematological factors and MR radiomics is constructed to accurately predicted pCR to NCRT in ESCC, which may be potentially useful to assist individualized preservation treatment of the esophagus.
View article: Heterogeneity of lymphocyte subsets in predicting immune checkpoint inhibitor treatment response in advanced lung cancer: an analysis across different pathological types, therapeutic drugs, and age groups
Heterogeneity of lymphocyte subsets in predicting immune checkpoint inhibitor treatment response in advanced lung cancer: an analysis across different pathological types, therapeutic drugs, and age groups Open
Our findings underscore the significant heterogeneity in the predictive value of distinct lymphocyte subsets for lung cancer patients undergoing ICI treatment. These findings are particularly salient when considering various pathological t…
View article: Preoperative CT-based radiomic prognostic index to predict the benefit of postoperative radiotherapy in patients with non-small cell lung cancer: a multicenter study
Preoperative CT-based radiomic prognostic index to predict the benefit of postoperative radiotherapy in patients with non-small cell lung cancer: a multicenter study Open
View article: Preoperative CT-Based Radiomic Prognostic Index to Predict the Benefit of Postoperative Radiotherapy in Patients with Non-Small Cell Lung Cancer: A Multicenter Study
Preoperative CT-Based Radiomic Prognostic Index to Predict the Benefit of Postoperative Radiotherapy in Patients with Non-Small Cell Lung Cancer: A Multicenter Study Open
Background The value of postoperative radiotherapy (PORT) for patients with non-small cell lung cancer (NSCLC) remains controversial. A subset of patients may benefit from PORT. We aimed to identify patients with NSCLC who could benefit fr…
View article: MR radiomics predicts pathological complete response of esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy: a multicenter study
MR radiomics predicts pathological complete response of esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy: a multicenter study Open
Background More than 40% of patients with resectable esophageal squamous cell cancer (ESCC) achieve pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT), who have favorable prognosis and may benefit from an organ…
View article: Postoperative radiotherapy improves disease-free survival of EGFR wild-type pN2 non-squamous- cell non-small-cell lung cancer (Nsq-NSCLC) patients after complete resection: a propensity score matching analysis
Postoperative radiotherapy improves disease-free survival of EGFR wild-type pN2 non-squamous- cell non-small-cell lung cancer (Nsq-NSCLC) patients after complete resection: a propensity score matching analysis Open
Background: The ADAURA study indicated that adjuvant TKI therapy improves survival in postoperative patients with EGFR-mutated (EGFRm) non-small-cell lung cancer (NSCLC), especially in stage III disease. However, the effect of PORT for sta…
View article: Enhanced prediction of postoperative radiotherapy‐induced esophagitis in non‐small cell lung cancer: Dosiomic model development in a real‐world cohort and validation in the <scp>PORT‐C</scp> randomized controlled trial
Enhanced prediction of postoperative radiotherapy‐induced esophagitis in non‐small cell lung cancer: Dosiomic model development in a real‐world cohort and validation in the <span>PORT‐C</span> randomized controlled trial Open
Background Radiotherapy‐induced esophagitis (RE) diminishes the quality of life and interrupts treatment in patients with non‐small cell lung cancer (NSCLC) undergoing postoperative radiotherapy. Dosimetric models showed limited capability…
View article: Higher Lung and Heart Doses Decrease Early and Long-Term Survival, Respectively, in Patients With Non-Small Cell Lung Cancer Undergoing Postoperative Radiation
Higher Lung and Heart Doses Decrease Early and Long-Term Survival, Respectively, in Patients With Non-Small Cell Lung Cancer Undergoing Postoperative Radiation Open
For patients with NSCLC undergoing PORT, a higher heart dose was associated with decreased long-term survival, whereas a higher lung dose was associated with decreased early survival.
View article: Efficacy and safety of neoadjuvant immunotherapy combined with chemoradiotherapy or chemotherapy in esophageal cancer: A systematic review and meta-analysis
Efficacy and safety of neoadjuvant immunotherapy combined with chemoradiotherapy or chemotherapy in esophageal cancer: A systematic review and meta-analysis Open
Background Significant progress has been made in the investigation of neoadjuvant immune-chemoradiotherapy (NICRT) and neoadjuvant immune-chemotherapy (NICT) on the outcomes of esophageal cancer patients. To summarize the current developme…
View article: Developing dosiomics models for the prediction of postoperative radiotherapy-induced esophagitis in patients with non-small cell lung cancer
Developing dosiomics models for the prediction of postoperative radiotherapy-induced esophagitis in patients with non-small cell lung cancer Open
Background: Radiotherapy-induced esophagitis (RE)diminishes quality of life and involves treatment interruption in patients with non-small cell lung cancer (NSCLC) undergoing postoperative radiotherapy. Dosimetric models showed limited cap…
View article: Famitinib enhances the antitumor effect of radioimmunotherapy in murine lung cancer
Famitinib enhances the antitumor effect of radioimmunotherapy in murine lung cancer Open
Background Combining antiangiogenic therapy with radioimmunotherapy is believed to further improve antitumor efficacy, but there is still a lack of evidence to support this. This study aimed to investigate the role of the tumor vascular‐ta…
View article: Comparison of different neoadjuvant treatments for resectable locoregional esophageal cancer: A systematic review and network <scp>meta‐analysis</scp>
Comparison of different neoadjuvant treatments for resectable locoregional esophageal cancer: A systematic review and network <span>meta‐analysis</span> Open
Purpose The best pattern of neoadjuvant therapy for resectable locoregional esophageal cancer has not been determined. Our study evaluated the efficacy and postoperative events of different treatments using the Bayesian network meta‐analys…
View article: Anlotinib Enhances the Antitumor Activity of High‐Dose Irradiation Combined with Anti‐PD‐L1 by Potentiating the Tumor Immune Microenvironment in Murine Lung Cancer
Anlotinib Enhances the Antitumor Activity of High‐Dose Irradiation Combined with Anti‐PD‐L1 by Potentiating the Tumor Immune Microenvironment in Murine Lung Cancer Open
Background . Radioimmunotherapy has become one of the most promising strategies for cancer treatment. Preclinical and clinical studies have demonstrated that antiangiogenic therapy can improve the efficacy of immunotherapy and sensitize ra…
View article: Postoperative radiotherapy improves survival of patients with <scp>ypN2</scp> non‐small cell lung cancer after neoadjuvant chemotherapy followed by surgery – A propensity score matching study of the Surveillance, Epidemiology, and End Results database
Postoperative radiotherapy improves survival of patients with <span>ypN2</span> non‐small cell lung cancer after neoadjuvant chemotherapy followed by surgery – A propensity score matching study of the Surveillance, Epidemiology, and End Results database Open
Background For patients with ypN2 non‐small cell lung cancer (NSCLC) after neoadjuvant chemotherapy followed by surgery (NCS), the role of postoperative radiotherapy (PORT) is unclear. The aim of our study was to evaluate the effect of POR…
View article: Treatment Optimization of Pelvic External Beam Radiation With/or Vaginal Brachytherapy for Patients with Stage I to II High-Risk Endometrioid Adenocarcinoma: A Retrospective Multi-Institutional Analysis
Treatment Optimization of Pelvic External Beam Radiation With/or Vaginal Brachytherapy for Patients with Stage I to II High-Risk Endometrioid Adenocarcinoma: A Retrospective Multi-Institutional Analysis Open
View article: Development and Validation of Deep Learning Model Based on CT Simulator Images to Predict 5-Year Recurrence of Stage IIIA-N2 Non–Small-Cell Lung Cancer Patients Treated with Surgery and Postoperative Radiotherapy
Development and Validation of Deep Learning Model Based on CT Simulator Images to Predict 5-Year Recurrence of Stage IIIA-N2 Non–Small-Cell Lung Cancer Patients Treated with Surgery and Postoperative Radiotherapy Open
View article: Adjuvant Radiotherapy is Safe and Effective for Patients with T1b-SM2 Esophageal Carcinoma After Endoscopic Resection – A Second Analysis From a Pilot Study
Adjuvant Radiotherapy is Safe and Effective for Patients with T1b-SM2 Esophageal Carcinoma After Endoscopic Resection – A Second Analysis From a Pilot Study Open
View article: Risk Factors of Brain Metastases in IIIA-N2 Non-Small Cell Lung Cancer After Complete Resection
Risk Factors of Brain Metastases in IIIA-N2 Non-Small Cell Lung Cancer After Complete Resection Open
View article: Endostar (<scp>rh‐endostatin</scp>) improves efficacy of concurrent chemoradiotherapy for locally advanced <scp>non‐small</scp> cell lung cancer: A systematic review and <scp>meta‐analysis</scp>
Endostar (<span>rh‐endostatin</span>) improves efficacy of concurrent chemoradiotherapy for locally advanced <span>non‐small</span> cell lung cancer: A systematic review and <span>meta‐analysis</span> Open
Background We aimed to clarify the benefits of the addition of rh‐endostatin into concurrent chemoradiotherapy (CCRT) versus CCRT alone for locally advanced non‐small cell lung cancer (NSCLC) by a meta‐analysis. Methods PubMed, Embase, Coc…
View article: Survival of Neoadjuvant and Adjuvant Therapy Compared With Surgery Alone for Resectable Esophageal Squamous Cell Carcinoma: A Systemic Review and Network Meta-Analysis
Survival of Neoadjuvant and Adjuvant Therapy Compared With Surgery Alone for Resectable Esophageal Squamous Cell Carcinoma: A Systemic Review and Network Meta-Analysis Open
Objective The optimal treatment for resectable esophageal squamous cell carcinoma (ESCC) remains controversial. Surgery is the primary treatment but with poor results. Attempts to improve patient survival have been made by introducing chem…
View article: Risk of cardiac‐related mortality in stage <scp>IIIA‐N2</scp> non‐small cell lung cancer: Analysis of the Surveillance, Epidemiology, and End Results (SEER) database
Risk of cardiac‐related mortality in stage <span>IIIA‐N2</span> non‐small cell lung cancer: Analysis of the Surveillance, Epidemiology, and End Results (SEER) database Open
Background In this study, we aimed to investigate the association between postoperative radiotherapy (PORT) and cardiac‐related mortality in patients with stage IIIA‐N2 non‐small cell lung cancer (NSCLC) using the Surveillance, Epidemiolog…