Zelin Cui
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View article: Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24‐Induced Ubiquitination of Paired Box 6
Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24‐Induced Ubiquitination of Paired Box 6 Open
This research aims to elucidate the mechanistic role of artesunate (ART) in enhancing the sensitivity of renal cell carcinoma (RCC) to sunitinib. To establish sunitinib‐resistant RCC cell lines (786‐O R and Caki‐1 R), cells were treated wi…
View article: Stop Overvaluing Multi-Agent Debate -- We Must Rethink Evaluation and Embrace Model Heterogeneity
Stop Overvaluing Multi-Agent Debate -- We Must Rethink Evaluation and Embrace Model Heterogeneity Open
Multi-agent debate (MAD) has gained significant attention as a promising line of research to improve the factual accuracy and reasoning capabilities of large language models (LLMs). Despite its conceptual appeal, current MAD research suffe…
View article: Pre-exposure to phage particles reduces their antibacterial therapeutic efficacy both in vitro and in vivo
Pre-exposure to phage particles reduces their antibacterial therapeutic efficacy both in vitro and in vivo Open
pre-exposure to phage particles may induce phage-neutralization antibodies and inhibit their therapeutic efficacies, delaying recovery or even exacerbating S. aureus-associated dermal abscesses for later treatment.
View article: KCNJ2 Facilitates Clear Cell Renal Cell Carcinoma Progression and Glucose Metabolism
KCNJ2 Facilitates Clear Cell Renal Cell Carcinoma Progression and Glucose Metabolism Open
Background: Clear cell renal cell carcinoma (ccRCC) is marked by aggressive characteristics and a poor prognosis. The involvement of KCNJ2, an inward rectifying potassium channel, in the progression of ccRCC, along with its potential roles…
View article: Construction and immunological evaluation of recombinant adenovirus vaccines of new novel NADC34-PRRSV strains in pigs
Construction and immunological evaluation of recombinant adenovirus vaccines of new novel NADC34-PRRSV strains in pigs Open
Introduction Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive and respiratory diseases in sow herds and piglets. The emergence of ORF5 RFLP 1–7-4-like (NADC34-like) PRRSV strain in China has brought a new rou…
View article: Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis (Adv. Sci. 38/2024)
Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis (Adv. Sci. 38/2024) Open
Lysine‐Lactylation In article number 2406333, Jian‐yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan, and co‐workers explore the protein lysine lactylation (Kla) landscape, identifying Kla as a key factor in cancer immunotherapy resistance. …
View article: Ear-canal lavage for curing noninvasive otomycosis: A prospective randomized controlled trial
Ear-canal lavage for curing noninvasive otomycosis: A prospective randomized controlled trial Open
Objective Fungal infection of the external auditory canal, otomycosis, is generally a resistant mycotic infection. We designed a prospective, randomized, controlled cohort study to analyse the treatment effect of ear canal lavage on otomyc…
View article: Study on in vivo and in vitro degradation of polydioxanone weaving tracheal stents
Study on in vivo and in vitro degradation of polydioxanone weaving tracheal stents Open
The appropriate degradation characteristics of polydioxanone (PDO) are necessary for the safety and effectiveness of stents. This study aimed to investigate the degradation of PDO weaving tracheal stents (PW stents) in vitro and in vivo . …
View article: An ensemble learning model for predicting cancer-specific survival of muscle-invasive bladder cancer patients undergoing bladder preservation therapy
An ensemble learning model for predicting cancer-specific survival of muscle-invasive bladder cancer patients undergoing bladder preservation therapy Open
The Catboost model exhibits the highest predictive performance and clinical utility, potentially aiding clinicians in making optimal individualized decisions for MIBC patients with BPT.
View article: Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis
Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis Open
Mortality rates due to lung cancer are high worldwide. Although PD‐1 and PD‐L1 immune checkpoint inhibitors boost the survival of patients with non‐small‐cell lung cancer (NSCLC), resistance often arises. The Warburg Effect, which causes l…
View article: Phenotypic and genetic characterization of hypervirulent Klebsiella pneumoniae in patients with liver abscess and ventilator-associated pneumonia
Phenotypic and genetic characterization of hypervirulent Klebsiella pneumoniae in patients with liver abscess and ventilator-associated pneumonia Open
Ventilator-associated pneumonia (VAP) and pyogenic liver abscess (PLA) due to Klebsiella pneumoniae infection can trigger life-threatening malignant consequences, however, there are few studies on the strain-associated clinical pathogenic …
View article: Trends in antimicrobial resistance of Escherichia coli and Klebsiella pneumoniae from 2016 to 2021 in Shanghai, China
Trends in antimicrobial resistance of Escherichia coli and Klebsiella pneumoniae from 2016 to 2021 in Shanghai, China Open
Objectives We sought to analyze the antimicrobial resistance trends of Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) isolated from patients. Methods Twelve commonly used antibiotics from E. coli and K. pneumoniae iso…
View article: Comparison of efficacy and safety of Retrograde intrarenal surgery and Percutaneous nephrolithotomy for the treatment of stones in horseshoe kidney: A systematic review and meta-analysis
Comparison of efficacy and safety of Retrograde intrarenal surgery and Percutaneous nephrolithotomy for the treatment of stones in horseshoe kidney: A systematic review and meta-analysis Open
Review question / Objective: To compare the efficacy and safety of PCNL and RIRS for the treantment of urolithiasis in HK patients.Condition being studied: Urolithiasis is the most common complication of horseshoe kidney(HK), which can be …
View article: Insights Into the Impact of Small RNA SprC on the Metabolism and Virulence of Staphylococcus aureus
Insights Into the Impact of Small RNA SprC on the Metabolism and Virulence of Staphylococcus aureus Open
Aim Our previous proteomic analysis showed that small RNA SprC (one of the small pathogenicity island RNAs) of Staphylococcus aureus possesses the ability to regulate the expression of multiple bacterial proteins. In this study, our object…
View article: Feasibility for SARS-CoV-2 Tests in the Hospital: An Exposure Analysis of Critical Control Points Approach
Feasibility for SARS-CoV-2 Tests in the Hospital: An Exposure Analysis of Critical Control Points Approach Open
This work aims to assess the feasibility of performing COVID-19 RNA tests in hospitals and communities experiencing SARS-CoV-2 virus outbreaks, to ultimately provide recommendations for hospitals with so-called fever clinics. In China, the…
View article: JD419, a Staphylococcus aureus Phage With a Unique Morphology and Broad Host Range
JD419, a Staphylococcus aureus Phage With a Unique Morphology and Broad Host Range Open
Phage therapy represents a possible treatment option to cure infections caused by multidrug-resistant bacteria, including methicillin and vancomycin-resistant Staphylococcus aureus , to which most antibiotics have become ineffective. In th…
View article: Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range
Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range Open
As an antimicrobial therapy, therapeutic phages, also known as “Phage therapy” are able to inactivate multi-drug resistant bacteria such as methicillin and vancomycin resistant S. aureus and thus present a possible treatment for infections…
View article: Feasibility for SARS-CoV-2 Tests in the Hospital: An Exposure Analysis of Critical Control Points Approach
Feasibility for SARS-CoV-2 Tests in the Hospital: An Exposure Analysis of Critical Control Points Approach Open
Objective Goal of this work is to assess the feasibility to perform COVID-19 RNA tests within hospitals and communities experiencing SARS-CoV-2 virus outbreaks, to ultimately provide recommendations for hospitals with so-called fever clini…
View article: Prevalence and molecular characterization of methicillin-resistant Staphylococcus aureus with mupirocin, fusidic acid and/or retapamulin resistance
Prevalence and molecular characterization of methicillin-resistant Staphylococcus aureus with mupirocin, fusidic acid and/or retapamulin resistance Open
Data on the prevalence of resistance to mupirocin (MUP), fusidic acid (FA) and retapamulin (RET) in methicillin-resistant Staphylococcus aureus (MRSA) from China are still limited. In this study we examined these three antibiotics resistan…
View article: Chronic <i>Staphylococcus aureus</i> Superantigen Toxic Shock Syndrome Toxin-1 Exposure Accelerates the Progression of Atherosclerosis in Rabbits.
Chronic <i>Staphylococcus aureus</i> Superantigen Toxic Shock Syndrome Toxin-1 Exposure Accelerates the Progression of Atherosclerosis in Rabbits. Open
Our data validated that chronic stimulation with TSST-1 facilitates the progression of atherosclerosis in rabbits independently of endotoxins, indicating that S. aureus and its SAgs may be targets to prevent and treat atherosclerosis.
View article: Exploring the whole standard operating procedure for phage therapy in clinical practice
Exploring the whole standard operating procedure for phage therapy in clinical practice Open
We have entered the post-antibiotic era. Phage therapy has recently been given renewed attention because bacteriophages are easily available and can kill bacteria. Many reports have demonstrated successful phage treatment of bacterial infe…
View article: Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice
Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice Open
Aim: In this study, Staphylococcus phage JD007 bactericidal activity and induced immune responses during treatment were assessed in a dermal abscess model. Materials and Methods: Dermal abscesses in nude mice were established by injecting …
View article: A Phage Lysin Fused to a Cell-Penetrating Peptide Kills Intracellular Methicillin-Resistant Staphylococcus aureus in Keratinocytes and Has Potential as a Treatment for Skin Infections in Mice
A Phage Lysin Fused to a Cell-Penetrating Peptide Kills Intracellular Methicillin-Resistant Staphylococcus aureus in Keratinocytes and Has Potential as a Treatment for Skin Infections in Mice Open
Staphylococcus aureus is the main pathogen that causes skin and skin structure infections and is able to survive and persist in keratinocytes of the epidermis. Since the evolution of multidrug-resistant bacteria, the use of phages and thei…
View article: The chemokine receptor CCR1 is identified in mast cell-derived exosomes.
The chemokine receptor CCR1 is identified in mast cell-derived exosomes. Open
Mast cells are important effector cells of the immune system, and mast cell-derived exosomes carrying RNAs play a role in immune regulation. However, the molecular function of mast cell-derived exosomes is currently unknown, and here, we i…
View article: Mast cell exosomes can suppress allergic reactions by binding to IgE
Mast cell exosomes can suppress allergic reactions by binding to IgE Open
Allergic diseases are characterized by the increased serum levels of total IgE and specific IgE against common allergens.1 After sensitization of susceptible individuals, the synthesis and binding of allergen-specific IgE to mast cells (MC…
View article: Isobaric Tags for Relative and Absolute Quantitation Proteomics Analysis of Gene Regulation by SprC in <i>Staphylococcus Aureus</i>
Isobaric Tags for Relative and Absolute Quantitation Proteomics Analysis of Gene Regulation by SprC in <i>Staphylococcus Aureus</i> Open
Our data provide a rich resource of SprC targets in S. aureus, although the mechanism of regulation by SprC is yet to be elucidated.
View article: A Comprehensive Epidemiological Research for Clinical Vibrio parahaemolyticus in Shanghai
A Comprehensive Epidemiological Research for Clinical Vibrio parahaemolyticus in Shanghai Open
Vibrio parahaemolyticus is one of the most important pathogen for seafood-borne gastroenteritis in Shanghai and the rest of the world. A total of 42 V. parahaemolyticus strains were isolated from 1900 fecal specimens collected from patient…
View article: Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China
Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China Open
The results suggested that Staphylococcus phage JD007 can potentially be used in phage therapy or for the detection of S. aureus.