Explanipedia

Nuclear-lamin-guided plastic positioning and folding of the human genome Open

Zehua Wang, Qianzhao Ji, Zunpeng Liu, Chongqing Jiao, Yiyuan Zhang , et al. · 2025

The human genome exhibits a highly ordered hierarchical architecture, yet the mechanisms governing its large-scale organization remain poorly understood. Here, we generate lamin single-, double-, and triple-knockout human embryonic and mes…

CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver Open

Hongyu Li, Min Wang, Xiaoyu Jiang, Yaobin Jing, Zeming Wu , et al. · 2024

Dysfunction of the ribosome manifests during cellular senescence and contributes to tissue aging, functional decline, and development of aging-related disorders in ways that have remained enigmatic. Here, we conducted a comprehensive CRISP…

Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging Open

Hui Zhang, Jiaming Li, Yang Yu, Jie Ren, Qiang Liu , et al. · 2023

(Cell Reports 42, 112593; June 27, 2023) In the originally published version of this article, there was an inaccurately presented picture in Figure 5J (si-NC panel). Figure 5 has been corrected in the paper online and also appears below. T…

Deciphering RNA m6A regulation in aging: Perspectives on current advances and future directions Open

Zeming Wu, Jie Ren, Guang‐Hui Liu · 2023

N 6 ‐methyladenosine (m 6 A) is a dynamic and reversible RNA modification that has emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various biological processes. In recent years, the potential involvemen…

An experimental workflow for identifying RNA m6A alterations in cellular senescence by methylated RNA immunoprecipitation sequencing Open

Yue Shi, Zeming Wu, Weiqi Zhang, Jing Qu, Weimin Ci , et al. · 2023

N6-methyladenosine (m6A), the most prevalent mRNA modification in eukaryotic cells, is known to play regulatory roles in a wide array of biological processes, including aging and cellular senescence. To investigate such roles, the m6A modi…

Distribution of drug-resistant genes in alveolar lavage fluid from patients with psittacosis and traceability analysis of causative organisms Open

Huiqun Lu, Jing Yuan, Zeming Wu, Lingwei Wang, Shuang Wu , et al. · 2023

Background Chlamydia psittaci is a small bacterium often found in birds, including poultry, and domesticated mammals, which causes psittacosis (or parrot fever) in humans. Different strains of C. psittaci respond variably to antibiotics, s…

Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging Open

Hui Zhang, Jiaming Li, Yang Yu, Jie Ren, Qiang Liu , et al. · 2023

The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However, the aging-associated molecular mechanisms remain unclear. Here, using physiologically aged non-human primates (NHPs), we depicted a comprehensive …

Effects of lncRNA HOXA11-AS on Sevoflurane-Induced Neuronal Apoptosis and Inflammatory Responses by Regulating miR-98-5p/EphA4 Open

Zhao Li, Zhonghui Wang, Haitao Chen, Yaxi Du, Weihao Ma , et al. · 2023

Objective. To explore the molecular mechanism of sevoflurane-induced neurotoxicity and to determine whether lncRNA HOXA11-AS affects sevoflurane-induced neuronal apoptosis and inflammation by regulating miR-98-5p/EphA4. Methods. Morris wat…

APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation Open

Hongkai Zhao, Kuan Yang, Yiyuan Zhang, Hongyu Li, Qianzhao Ji , et al. · 2023

Glutathione restoration: a sword to combat skeletal muscle stem cell aging Open

Zeming Wu, Jie Ren, Guang‐Hui Liu · 2023

In a recent study published in Cell Metabolism, Thomas A. Rando and colleagues reported a critical role of dysregulated glutathione (GSH) metabolism in driving the aging process of skeletal muscle stem cells (MuSCs), uncovering a novel mec…

A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats Open

Lingling Geng, Bin Zhang, Haisong Liu, Si Wang, Yusheng Cai , et al. · 2022

Metformin (MET) and nicotinamide riboside (NR) have both been reported to exert geroprotective effects in multiple species. However, the mechanism by which MET and NR regulate the aging program and delay aging in multiple tissues remains u…

4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis Open

Yifang He, Qianzhao Ji, Zeming Wu, Yusheng Cai, Jian Yin , et al. · 2022

Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown. Here, we report that the expression of 4E-BP1 decreases al…

Emerging role of RNA m6A modification in aging regulation Open

Zeming Wu, Si Wang, Juan Carlos Izpisúa Belmonte, Weiqi Zhang, Jing Qu , et al. · 2022

Correction to: mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells Open

Qun Chu, Fei‐Fei Liu, Yifang He, Xiaofei Jiang, Yusheng Cai , et al. · 2022

FTO stabilizes MIS12 and counteracts senescence Open

Sheng Zhang, Zeming Wu, Yue Shi, Si Wang, Jie Ren , et al. · 2022

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor Open

Zunpeng Liu, Wei Li, Lingling Geng, Liang Sun, Qiaoran Wang , et al. · 2022

Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might be conserved across species, and if so, whether such metabolic drivers might be h…

mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells Open

Qun Chu, Feifei Liu, Yifang He, Xiaoyu Jiang, Yusheng Cai , et al. · 2022

OUP accepted manuscript Open

Chuqian Liang, Qiong Ke, Zunpeng Liu, Jie Ren, Weiqi Zhang , et al. · 2022

Aging in humans is intricately linked with alterations in circadian rhythms concomitant with physiological decline and stem cell exhaustion. However, whether the circadian machinery directly regulates stem cell aging, especially in primate…

Hyperthermia differentially affects specific human stem cells and their differentiated derivatives Open

Si Wang, Fang Cheng, Qianzhao Ji, Moshi Song, Zeming Wu , et al. · 2021

Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells Open

Hezhen Shan, Lingling Geng, Xiaoyu Jiang, Moshi Song, Jianxun Wang , et al. · 2021

Correction to ‘SIRT3 consolidates heterochromatin and counteracts senescence’ Open

Zhiqing Diao, Qianzhao Ji, Zeming Wu, Weiqi Zhang, Yusheng Cai , et al. · 2021

Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis Open

Jinghui Lei, Xiaoyu Jiang, Wei Li, Jie Ren, Datao Wang , et al. · 2021

SIRT3 consolidates heterochromatin and counteracts senescence Open

Zhiqing Diao, Qianzhao Ji, Zeming Wu, Weiqi Zhang, Yusheng Cai , et al. · 2021

Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remain…

Resurrection of endogenous retroviruses during aging reinforces senescence Open

Xiaoqian Liu, Zunpeng Liu, Zeming Wu, Jie Ren, Yanling Fan , et al. · 2021

SUMMARY Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the aging process are largely unknown. In human senescent cells,…

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA Open

Zeming Wu, Yue Shi, Mingming Lu, Moshi Song, Zihui Yu , et al. · 2020

N6-Methyladenosine (m6A) messenger RNA methylation is a well-known epitranscriptional regulatory mechanism affecting central biological processes, but its function in human cellular senescence remains uninvestigated. Here, we found that le…

Single-cell transcriptomic atlas of primate cardiopulmonary aging Open

Shuai Ma, Shuhui Sun, Jiaming Li, Yanling Fan, Jing Qu , et al. · 2020

Aging is a major risk factor for many diseases, especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019 (COVID-19). Resolving cellular and molecular mechanisms associated with…

Identification of Critical Pathways and Hub Genes in LanCL1-Overexpressed Prostate Cancer Cells Open

Run Tang, Zeming Wu, Feng Lü, Cheng Wang, Bo Wu , et al. · 2020

Our results suggest the critical genes and pathways that might play key roles after LanCL1 overexpression in prostate cancer. We also provide candidate gene targets that might play important roles in prostate cancer development.

Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration Open

Chuqian Liang, Zunpeng Liu, Moshi Song, Wei Li, Zeming Wu , et al. · 2020

ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells Open

Hongyu Li, Zeming Wu, Xiaoqian Liu, Sheng Zhang, Qianzhao Ji , et al. · 2020

Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming Open

Pengze Yan, Zunpeng Liu, Moshi Song, Zeming Wu, Wei Xu , et al. · 2020

DNA:RNA hybrids play key roles in both physiological and disease states by regulating chromatin and genome organization. Their homeostasis during cell differentiation and cell plasticity remains elusive. Using an isogenic human stem cell p…

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