Zenan Huang
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View article: LLaDA-MoE: A Sparse MoE Diffusion Language Model
LLaDA-MoE: A Sparse MoE Diffusion Language Model Open
We introduce LLaDA-MoE, a large language diffusion model with the Mixture-of-Experts (MoE) architecture, trained from scratch on approximately 20T tokens. LLaDA-MoE achieves competitive performance with significantly reduced computational …
View article: Reinforcement Learning with Rubric Anchors
Reinforcement Learning with Rubric Anchors Open
Reinforcement Learning from Verifiable Rewards (RLVR) has emerged as a powerful paradigm for enhancing Large Language Models (LLMs), exemplified by the success of OpenAI's o-series. In RLVR, rewards are derived from verifiable signals-such…
View article: 280. TRANSLATIONAL PHARMACOKINETIC-PHARMACODYNAMIC MODELING OF PRECLINICAL AND CLINICAL DATA OF THE TRIPLE REUPTAKE INHIBITOR JS1-1-01 TO DETERMINE THE RECOMMENDED PHASE II DOSE
280. TRANSLATIONAL PHARMACOKINETIC-PHARMACODYNAMIC MODELING OF PRECLINICAL AND CLINICAL DATA OF THE TRIPLE REUPTAKE INHIBITOR JS1-1-01 TO DETERMINE THE RECOMMENDED PHASE II DOSE Open
Background JS1-1-01 is a novel dual-action mechanism antidepressant. The studies, in vitro and in vivo, have demonstrated that JS1-1-01 and its metabolite exhibit inhibitory effects on the uptake of dopamine (DA), serotonin (5-HT), and nor…
View article: Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma
Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma Open
View article: Association between systemic inflammatory indicators on admission and mortality in critically ill patients with diabetic kidney disease based on the MIMIC-IV database: a cohort study
Association between systemic inflammatory indicators on admission and mortality in critically ill patients with diabetic kidney disease based on the MIMIC-IV database: a cohort study Open
Introduction Diabetic kidney disease (DKD) is linked to immunity and inflammation. We aimed to investigate if systemic inflammatory indicators can predict mortality in DKD patients in intensive care units (ICUs) and determine potential ass…
View article: The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia
The role of Triglyceride Glucose-Waist Circumference (TyG_WC) in predicting metabolic dysfunction-associated steatotic liver disease among individuals with hyperuricemia Open
View article: TPMS‐Gyroid Scaffold‐Mediated Up‐Regulation of ITGB1 for Enhanced Cell Adhesion and Immune‐Modulatory Osteogenesis
TPMS‐Gyroid Scaffold‐Mediated Up‐Regulation of ITGB1 for Enhanced Cell Adhesion and Immune‐Modulatory Osteogenesis Open
The porous structure is crucial in bone tissue engineering for promoting osseointegration. Among various structures, triply periodic minimal surfaces (TPMS) ‐Gyroid has been extensively studied due to its superior mechanical and biological…
View article: Iterative Tree Analysis for Medical Critics
Iterative Tree Analysis for Medical Critics Open
Large Language Models (LLMs) have been widely adopted across various domains, yet their application in the medical field poses unique challenges, particularly concerning the generation of hallucinations. Hallucinations in open-ended long m…
View article: Biodegradable Microneedle Patch for Transdermal ClopidogrelDelivery
Biodegradable Microneedle Patch for Transdermal ClopidogrelDelivery Open
View article: A Decision model for merchandise replenishment based on logistic regression and ARIMA time series forecasting
A Decision model for merchandise replenishment based on logistic regression and ARIMA time series forecasting Open
In supermarkets or shopping malls that mainly deal with fresh food, vegetable commodities are generally difficult to store for a long time with a short freshness period. And the quality of vegetables and storage time present a certain rela…
View article: Research on Symmetrical Flexible Clamping Conveyor for Scallion Harvester
Research on Symmetrical Flexible Clamping Conveyor for Scallion Harvester Open
Aiming at the problems of low conveying efficiency, poor adaptability of conveying Scallion poles of different diameters, and little innovation of the mechanism that exist in the existing clamping conveyor device, a symmetrical flexible cl…
View article: SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1β pathway
SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1β pathway Open
Intervertebral disc is a highly rhythmical tissue. As a key factor linking biorhythm and inflammatory response, the shielding effect of NR1D1 in the process of intervertebral disc degeneration remains unclear. Here, we first confirmed that…
View article: Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy
Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy Open
3, 4, 5, and S3.
View article: Melatonin alleviates oxidative stress-induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway
Melatonin alleviates oxidative stress-induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway Open
This study indicates that melatonin can effectively alleviate the excessive apoptosis and mitochondrial dysfunction of NPMSCs through activating the PI3K/Akt pathway. Melatonin might serve as a promising candidate for the prevention and tr…
View article: Latent Processes Identification From Multi-View Time Series
Latent Processes Identification From Multi-View Time Series Open
Understanding the dynamics of time series data typically requires identifying the unique latent factors for data generation, a.k.a., latent processes identification. Driven by the independent assumption, existing works have made great prog…
View article: Latent Processes Identification From Multi-View Time Series
Latent Processes Identification From Multi-View Time Series Open
Understanding the dynamics of time series data typically requires identifying the unique latent factors for data generation, \textit{a.k.a.}, latent processes identification. Driven by the independent assumption, existing works have made g…
View article: Discriminative Radial Domain Adaptation
Discriminative Radial Domain Adaptation Open
Domain adaptation methods reduce domain shift typically by learning domain-invariant features. Most existing methods are built on distribution matching, e.g., adversarial domain adaptation, which tends to corrupt feature discriminability. …
View article: Melatonin alleviat es oxidative stress -induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway
Melatonin alleviat es oxidative stress -induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway Open
Background Intervertebral disc degenerative disease(IVDD)is one of the main causes of low back pain, causing serious economic burden to the society. The changes of microenvironment in the degenerative intervertebral disc cause oxidative st…
View article: Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy
Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy Open
Fibroblast growth factor receptor 2 (FGFR2) is a membrane‐spanning tyrosine kinase that mediates FGF signaling. Various FGFR2 alterations are detected in breast cancer, yet it remains unclear if activation of FGFR2 signaling initiates tumo…
View article: Influence of simvastatin on the biological behavior of nucleus pulposus-derived mesenchymal stem cells.
Influence of simvastatin on the biological behavior of nucleus pulposus-derived mesenchymal stem cells. Open
Proper concentration of simvastatin can promote the biological behavior of NPMSC, and HIF-1α-intermediated signaling pathway might participate in the mechanism.
View article: Leptin changes differentiation fate and induces senescence in chondrogenic progenitor cells
Leptin changes differentiation fate and induces senescence in chondrogenic progenitor cells Open