Ping Zeng
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View article: Early Neurological Deterioration After Recanalization: A Retrospective Study of 1053 EVT Patients
Early Neurological Deterioration After Recanalization: A Retrospective Study of 1053 EVT Patients Open
View article: Mediating role of psychological resilience in the relationship between leisure-time activities and long-term mortality in older adults
Mediating role of psychological resilience in the relationship between leisure-time activities and long-term mortality in older adults Open
Psychological resilience mediated the association between LTAs and all-cause mortality. Frequent participation in leisure activities may play a beneficial role in preventing premature death by improving resilience levels in community-dwell…
View article: Targeting <scp>IL</scp> ‐1 in Autoinflammatory Syndromes: Lessons From Canakinumab and <scp>VEXAS</scp> Syndrome
Targeting <span>IL</span> ‐1 in Autoinflammatory Syndromes: Lessons From Canakinumab and <span>VEXAS</span> Syndrome Open
View article: Impact of changes in leisure activities on incident disability among older adults: a nationwide cohort study
Impact of changes in leisure activities on incident disability among older adults: a nationwide cohort study Open
Maintaining high participation and increasing participation in LAs are associated with a lower risk of ADL disability in community-dwelling older individuals. Therefore, promoting participation in LAs represents a practical strategy to pre…
View article: Exploring the pathogenesis of steroid-induced osteonecrosis of the femoral head co-regulated by mesenchymal stem cells and pyroptosis-related genes with the use of transcriptome
Exploring the pathogenesis of steroid-induced osteonecrosis of the femoral head co-regulated by mesenchymal stem cells and pyroptosis-related genes with the use of transcriptome Open
View article: Uncovering psychologically mediated pathways to cardiovascular diseases: depressive symptoms as a mediator between childhood maltreatment and single or multiple cardiovascular disease comorbidities
Uncovering psychologically mediated pathways to cardiovascular diseases: depressive symptoms as a mediator between childhood maltreatment and single or multiple cardiovascular disease comorbidities Open
Objective Childhood maltreatment (CM) increases the risk of cardiovascular disease (CVD), but the mediating mechanism of depressive symptoms in this process has not been fully elucidated. To further elucidate the potential mechanisms of de…
View article: Advancements in Therapeutic Approaches and Biomarkers: A New Epoch for Sjögren's Syndrome Management
Advancements in Therapeutic Approaches and Biomarkers: A New Epoch for Sjögren's Syndrome Management Open
View article: A comprehensive exploration of the impact and contribution of polygenic risk score on age at onset of 30 complex diseases
A comprehensive exploration of the impact and contribution of polygenic risk score on age at onset of 30 complex diseases Open
Higher PRS generally leads to earlier age at onset, which supports the potential role of PRS in screening high early-onset risk individuals susceptible to chronic diseases.
View article: Glucocorticoid-mediated acetylated regulation of glucocorticoid receptor and Histone3/Histone4 influence glucocorticoid heterogeneity in children patients with primary nephrotic syndrome
Glucocorticoid-mediated acetylated regulation of glucocorticoid receptor and Histone3/Histone4 influence glucocorticoid heterogeneity in children patients with primary nephrotic syndrome Open
Background Glucocorticoid (GC) response heterogeneity has been recognized as an unfavorable prognostic factor, yet the underlying mechanism remains elusive. In this study, we endeavored to investigate the potential causes from an epigeneti…
View article: Establishing a robust triangulation framework to explore the relationship between hearing loss and Parkinson’s disease
Establishing a robust triangulation framework to explore the relationship between hearing loss and Parkinson’s disease Open
View article: Long-Term Impact of Chronic Obstructive Pulmonary Disease on Mortality in Heart Failure
Long-Term Impact of Chronic Obstructive Pulmonary Disease on Mortality in Heart Failure Open
View article: Broad Evidence Triangulation Should Be Established for a Valid and Robust Causal Relation Between Air Pollution and Health Outcome
Broad Evidence Triangulation Should Be Established for a Valid and Robust Causal Relation Between Air Pollution and Health Outcome Open
This letter aims to provide valuable insights into broader evidence triangulation (i.e., a well-designed primary association analysis followed by elaborate approaches to control residual confounding effects from various design and modeling…
View article: Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease
Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease Open
Co-exposure to multiple air pollutants could increase the risk of developing CKD, with accelerated aging serving as a partial mechanism in the relationship between air pollution and CKD. These findings highlight the importance of reducing …
View article: 114P Cadonilimab plus chemotherapy as first-line (1L) treatment for metastatic gastric (G) or gastroesophageal junction adenocarcinoma (GEJA) with PD-L1 CPS≤5: Updated results from a real-world study
114P Cadonilimab plus chemotherapy as first-line (1L) treatment for metastatic gastric (G) or gastroesophageal junction adenocarcinoma (GEJA) with PD-L1 CPS≤5: Updated results from a real-world study Open
View article: Polygenic prediction for underrepresented populations through transfer learning by utilizing genetic similarity shared with European populations
Polygenic prediction for underrepresented populations through transfer learning by utilizing genetic similarity shared with European populations Open
Because current genome-wide association studies are primarily conducted in individuals of European ancestry and information disparities exist among different populations, the polygenic score derived from Europeans thus exhibits poor transf…
View article: Breastfeeding, genetic susceptibility, and the risk of asthma and allergic diseases in children and adolescents: a retrospective national population-based cohort study
Breastfeeding, genetic susceptibility, and the risk of asthma and allergic diseases in children and adolescents: a retrospective national population-based cohort study Open
This study provided supportive evidence for the risk-reduced effect of breastfeeding on asthma, allergic diseases, and the comorbidity in children and adolescents, and further revealed that such an influence was consistent across distinct …
View article: Plant-based index linked to fall risk in older Chinese adults: cross-sectional evidence from a national cohort
Plant-based index linked to fall risk in older Chinese adults: cross-sectional evidence from a national cohort Open
View article: Temporal Feature Prediction in Audio–Visual Deepfake Detection
Temporal Feature Prediction in Audio–Visual Deepfake Detection Open
The rapid growth of deepfake technology, generating realistic manipulated media, poses a significant threat due to potential misuse. Therefore, effective detection methods are urgently needed to prevent malicious use, as current approaches…
View article: Association of cigarette smoking, smoking cessation with the risk of cardiometabolic multimorbidity in the UK Biobank
Association of cigarette smoking, smoking cessation with the risk of cardiometabolic multimorbidity in the UK Biobank Open
View article: Identification of potential shared gene signatures between gastric cancer and type 2 diabetes: a data-driven analysis
Identification of potential shared gene signatures between gastric cancer and type 2 diabetes: a data-driven analysis Open
Background Gastric cancer (GC) and type 2 diabetes (T2D) contribute to each other, but the interaction mechanisms remain undiscovered. The goal of this research was to explore shared genes as well as crosstalk mechanisms between GC and T2D…
View article: Correction: Sodium, potassium intake, and all-cause mortality: confusion and new findings
Correction: Sodium, potassium intake, and all-cause mortality: confusion and new findings Open
View article: Multilocular thymic cysts can be easily misdiagnosed as malignant tumor on computer tomography: A case report
Multilocular thymic cysts can be easily misdiagnosed as malignant tumor on computer tomography: A case report Open
BACKGROUND Multilocular thymic cyst (MTC) is a rare mediastinal lesion which is considered to occur in the process of acquired inflammation. It is usually characterized by well-defined cystic density and is filled with transparent liquid. …
View article: Incorporating genetic similarity of auxiliary samples into eGene identification under the transfer learning framework
Incorporating genetic similarity of auxiliary samples into eGene identification under the transfer learning framework Open
Background The term eGene has been applied to define a gene whose expression level is affected by at least one independent expression quantitative trait locus (eQTL). It is both theoretically and empirically important to identify eQTLs and…
View article: Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort
Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort Open
Objectives: This study aimed to evaluate the joint effects of multiple air pollutants including PM 2.5 , PM 10 , NO 2 , and NO x with dementia and examined the modifying effects of genetic susceptibility. Methods: This study included 220,9…
View article: Investigating the Relationship between Birthweight and Breast Cancer from A Non-Linear and Mediation Perspective
Investigating the Relationship between Birthweight and Breast Cancer from A Non-Linear and Mediation Perspective Open
Background: Epidemiological studies have shown a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations emerged. We re-explored the association between them in the UK …
View article: Variety ACEs and risk of developing anxiety, depression, or anxiety-depression co-morbidity: the 2006–2022 UK Biobank data
Variety ACEs and risk of developing anxiety, depression, or anxiety-depression co-morbidity: the 2006–2022 UK Biobank data Open
Objectives Adverse childhood experiences (ACEs) and anxiety-depression co-morbidity are attracting widespread attention. Previous studies have shown the relationship between individual psychiatric disorders and ACEs. This study will analyz…
View article: Evaluating causal influence of maternal educational attainment on offspring birthweight via observational study and Mendelian randomization analyses
Evaluating causal influence of maternal educational attainment on offspring birthweight via observational study and Mendelian randomization analyses Open
View article: Doing housework and having regular daily routine standing out as factors associate with physical function in the older people
Doing housework and having regular daily routine standing out as factors associate with physical function in the older people Open
Background and objectives Nationwide data were used to explore factors associated with physical function in order to identify interventions that could improve and maintain physical function in the older people. Methods The physical functio…
View article: Influence of social deprivation on morbidity and all-cause mortality of cardiometabolic multi-morbidity: a cohort analysis of the UK Biobank cohort
Influence of social deprivation on morbidity and all-cause mortality of cardiometabolic multi-morbidity: a cohort analysis of the UK Biobank cohort Open
Background The relation of social deprivation with single cardiometabolic disease (CMD) was widely investigated, whereas the association with cardiometabolic multi-morbidity (CMM), defined as experiencing more than two CMDs during the life…
View article: Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis Open
Current genome-wide association studies of frontotemporal dementia (FTD) are underpowered due to limited samples. Further, common genetic etiologies between FTD and amyotrophic lateral sclerosis (ALS) remain unknown. Using the largest summ…