Lingyu Zeng
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View article: Human placenta-derived endothelial progenitor cells: an animal-free culture system for efficient expansion
Human placenta-derived endothelial progenitor cells: an animal-free culture system for efficient expansion Open
Background Endothelial progenitor cells (EPCs) play a critical role in vasculogenesis and vascular repair, but their clinical application is hindered by challenges such as cell purity, quantity, and reliance on fetal bovine serum (FBS). Th…
View article: Platelet NLRP6 protects against microvascular thrombosis in sepsis
Platelet NLRP6 protects against microvascular thrombosis in sepsis Open
Sepsis is characterized by a systemic inflammation and microvascular thrombosis induced by infection. The nucleotide-oligomerization domain–like receptor family pyrin domain containing 6 protein (NLRP6) possesses both proinflammatory and a…
View article: Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation
Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation Open
View article: Naringin promotes osteogenic potential in bone marrow-derived mesenchymal stem cells via mediation of miR-26a/Ski axis
Naringin promotes osteogenic potential in bone marrow-derived mesenchymal stem cells via mediation of miR-26a/Ski axis Open
Naringin could promote osteogenic differentiation of BMSCs via mediation of miR-26a/Ski axis. Thereby, Naringin might be a new agent for ONFH treatment.
View article: Recent advances and research progress regarding monoclonal antibodies for chronic graft-versus-host disease
Recent advances and research progress regarding monoclonal antibodies for chronic graft-versus-host disease Open
Chronic graft-versus-host disease (cGVHD) is one of the leading causes of mortality following allogeneic hematopoietic stem cell transplantation (HSCT), with only 50 % of patients responding to conventional corticosteroids with or without …
View article: Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial
Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial Open
Despite the high therapeutic response achieved with B-cell maturation antigen (BCMA)-specific chimeric antigen receptor (CAR) T-cell therapy in relapsed and refractory multiple myeloma (R/R MM), primary resistance and relapse exist with si…
View article: Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution Open
Bone marrow ablation is routinely performed before hematopoietic stem cell transplantation (HSCT). Hematopoietic stem and progenitor cells (HSPCs) require a stable bone marrow microenvironment to expand and refill the peripheral blood cell…
View article: PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model
PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model Open
View article: [The effect of platelet infusion on the repair of bone marrow hematopoietic niche damage in mice induced by (60)Co radiation and hematopoietic reconstruction after bone marrow transplantation].
[The effect of platelet infusion on the repair of bone marrow hematopoietic niche damage in mice induced by (60)Co radiation and hematopoietic reconstruction after bone marrow transplantation]. Open
Objective: To observe the effect of platelets on hematopoietic stem cell (HSCs) implantation in mice with radiation-induced bone marrow injury and bone marrow transplantation models. Methods: ①Male C57BL/6 mice were divided i…
View article: MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis
MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis Open
Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Expression and functional roles of MTH1 in platelets are not know…
View article: Research on Road Network Partitioning Considering the Coupling of Network Connectivity and Traffic Attributes
Research on Road Network Partitioning Considering the Coupling of Network Connectivity and Traffic Attributes Open
The urban road network is a large and complex system characterized by significant heterogeneity arising from different spatial structures and traffic demands. To facilitate effective management and control, it is necessary to partition the…
View article: P1259: HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS AMELIORATE ACUTE GRAFT VERSUS HOST DISEASE BY ELEVATING PHYTOSPHINGOSINE
P1259: HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS AMELIORATE ACUTE GRAFT VERSUS HOST DISEASE BY ELEVATING PHYTOSPHINGOSINE Open
Topic: 21. Stem cell transplantation - Experimental Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for malignant hematological diseases. However, acute graft-versus-host disease (aGVHD)…
View article: P1284: THE TEAR CYTOKINE PANEL IS A USEFUL BIOMARKER FOR EARLY DIAGNOSIS AND SEVERITY-EVALUATING OF OCULAR CHRONIC GRAFT-VERSUS-HOST DISEASE
P1284: THE TEAR CYTOKINE PANEL IS A USEFUL BIOMARKER FOR EARLY DIAGNOSIS AND SEVERITY-EVALUATING OF OCULAR CHRONIC GRAFT-VERSUS-HOST DISEASE Open
Topic: 22. Stem cell transplantation - Clinical Background: Chronic graft-versus-host disease (cGVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), affecting 30–70% of patients after allo-HS…
View article: Catalytic Conversion of Carbohydrates into 5-Hydroxymethylfurfural by Phosphotungstic Acid Encapsulated in MIL-101 (Cr, Sn) Catalyst in Deep Eutectic Solvents
Catalytic Conversion of Carbohydrates into 5-Hydroxymethylfurfural by Phosphotungstic Acid Encapsulated in MIL-101 (Cr, Sn) Catalyst in Deep Eutectic Solvents Open
Herein, we report the synthesis of bimetal–organic frameworks (BMOFs) with both Brønsted and Lewis acidities, in which phosphotungstic acid (PTA) was encapsulated in BMOFs. It is efficient in converting starch to 5-hydroxymethyl-furfural (…
View article: Clodronate liposomes may biases MSC differentiation toward adipogenesis through activation of NLRP3
Clodronate liposomes may biases MSC differentiation toward adipogenesis through activation of NLRP3 Open
The results of this study suggest that MSC are biased towards adipocyte generation in response to Clod-Lipo, a process that may be associated with activation of the NLRP3/caspase-1 pathway.
View article: miR-302 Cluster Inhibits Angiogenesis and Growth of K562 Leukemia Cells by Targeting VEGFA [Retraction]
miR-302 Cluster Inhibits Angiogenesis and Growth of K562 Leukemia Cells by Targeting VEGFA [Retraction] Open
[This retracts the article DOI: 10.2147/OTT.S190146.].
View article: SCARdock: A Web Server and Manually Curated Resource for Discovering Covalent Ligands
SCARdock: A Web Server and Manually Curated Resource for Discovering Covalent Ligands Open
The SCARdock server and the accompanied data sets would be of great value to the discovery of covalent ligands and are available freely at http://www.liugroup.site/scardock/ or https://scardock.com.
View article: Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions
Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions Open
Background Hematopoietic stem cell transplantation involves irradiation preconditioning which causes bone marrow endothelial cell dysfunction. While much emphasis is on the reconstitution of hematopoietic stem cells in the bone marrow micr…
View article: EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation
EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation Open
Introduction Graft-versus-host disease (GVHD) damages vascular endothelium. Endothelial progenitor cell (EPC) can differentiate to endothelial cell and promote angiogenesis, but its role in endothelial damage in GVHD is unclear. Methods In…
View article: Prolonged hematological toxicity in patients receiving BCMA/CD19 CAR-T-cell therapy for relapsed or refractory multiple myeloma
Prolonged hematological toxicity in patients receiving BCMA/CD19 CAR-T-cell therapy for relapsed or refractory multiple myeloma Open
Although chimeric antigen receptor T (CAR-T) cell therapy has been indicated to be effective in treating relapsed or refractory multiple myeloma (R/R MM), severe hematological toxicity (HT) remains an intractable issue. This study enrolled…
View article: Liposomes trigger bone marrow niche macrophage “foam” cell formation and affect hematopoiesis in mice
Liposomes trigger bone marrow niche macrophage “foam” cell formation and affect hematopoiesis in mice Open
View article: Effects of the PLK4 inhibitor Centrinone on the biological behaviors of acute myeloid leukemia cell lines
Effects of the PLK4 inhibitor Centrinone on the biological behaviors of acute myeloid leukemia cell lines Open
Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, is frequently overexpressed in cancer cells. However, roles and the mechanism of PLK4 in the leukemiagenesis of acute myeloid leukemia (AML) remain unclear. In this study,…
View article: Correlation of Cytokine Release Syndrome With Prognosis After Chimeric Antigen Receptor T Cell Therapy: Analysis of 54 Patients With Relapsed or Refractory Multiple Myeloma
Correlation of Cytokine Release Syndrome With Prognosis After Chimeric Antigen Receptor T Cell Therapy: Analysis of 54 Patients With Relapsed or Refractory Multiple Myeloma Open
Although chimeric antigen receptor T (CAR-T) cell therapy has proven to be effective in treating relapsed or refractory multiple myeloma (R/R MM), the severity of cytokine release syndrome (CRS) can affect patient survival and the risk fac…
View article: Intravital lipid droplet labeling and imaging reveals the phenotypes and functions of individual macrophages in vivo
Intravital lipid droplet labeling and imaging reveals the phenotypes and functions of individual macrophages in vivo Open
View article: Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells [Corrigendum]
Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells [Corrigendum] Open
[This corrects the article DOI: 10.2147/JIR.S318812.].
View article: Safety and efficacy of a humanized <scp>CD19</scp> chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic leukemia
Safety and efficacy of a humanized <span>CD19</span> chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic leukemia Open
CD19‐targeted chimeric antigen receptor T (CAR‐T) cells using murine single‐chain variable fragment (scFv) has shown substantial clinical efficacy in treating relapsed/refractory acute lymphoblastic leukemia (R/R ALL). However, potential i…
View article: Correction to: Irradiation induces homing of donor endothelial progenitor cells in allogeneic hematopoietic stem cell transplantation
Correction to: Irradiation induces homing of donor endothelial progenitor cells in allogeneic hematopoietic stem cell transplantation Open
View article: Predictive role of endothelial cell activation in cytokine release syndrome after chimeric antigen receptor T cell therapy for acute lymphoblastic leukaemia
Predictive role of endothelial cell activation in cytokine release syndrome after chimeric antigen receptor T cell therapy for acute lymphoblastic leukaemia Open
CD19‐target chimeric antigen receptor (CAR)‐T cell therapy is highly effective for relapsed/refractory (R/R) acute lymphoblastic leukaemia (ALL), but is often complicated by cytokine release syndrome (CRS), which is potentially life‐threat…
View article: The Evolution of Data-Driven Modeling in Organic Chemistry
The Evolution of Data-Driven Modeling in Organic Chemistry Open
Organic chemistry is replete with complex relationships: for example, how a reactant's structure relates to the resulting product formed; how reaction conditions relate to yield; how a catalyst's structure relates to enantioselectivity. Qu…
View article: Dimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse
Dimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse Open
Background Immune thrombocytopenia (ITP) is an autoimmune disease characterized as a low platelet count resulting from immune-mediated platelet destruction. Dimethyl fumarate (DMF) is widely applied for the treatment of several autoimmune …