Zengchang Pang
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View article: Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts
Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts Open
Our findings suggested that expanded mCAs were significantly associated with all-cause and cause-specific deaths and could serve as a complement to the FI in providing a more comprehensive perspective on mortality risk, especially for canc…
View article: Unveiling the mechanism of Lonicera japonica Thunb. polyphenols against Cronobacter sakazakii from powdered infant formula by untargeted metabolomics and its application as a natural disinfectant
Unveiling the mechanism of Lonicera japonica Thunb. polyphenols against Cronobacter sakazakii from powdered infant formula by untargeted metabolomics and its application as a natural disinfectant Open
Contamination by Cronobacter sakazakii in powdered infant formula (PIF) and the potential hazards of chemical disinfectants are pressing issues requiring urgent resolution. This study aimed to investigate the antibacterial activity and mec…
View article: Expert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology
Expert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology Open
Large language models generate plausible text responses to medical questions, but inaccurate responses pose significant risks in medical decision-making. Grading LLM outputs to determine the best model or answer is time-consuming and impra…
View article: Combined use of molar distalization and leeway space for class II division 1 malocclusion with odontoma-induced impacted maxillary right lateral incisor in the mixed dentition: a case report
Combined use of molar distalization and leeway space for class II division 1 malocclusion with odontoma-induced impacted maxillary right lateral incisor in the mixed dentition: a case report Open
Molar distalization and use of the leeway space can avoid the need for tooth extraction during orthodontic treatment. Molar distalization and use of the leeway space can provide sufficient space to correct Class II molar relationship, alig…
View article: Long-term effects of health during childhood on depressive symptoms in later life: evidence from a nationally representative survey in China
Long-term effects of health during childhood on depressive symptoms in later life: evidence from a nationally representative survey in China Open
Our findings suggest that childhood health may influence mental well-being in later life. Promoting healthy behaviors from early childhood could help reduce depression risk in older age. However, the reliance on self-reported data and a cr…
View article: The metabolic signature of blood lipids: a causal inference study using twins
The metabolic signature of blood lipids: a causal inference study using twins Open
Dyslipidemia is one of the cardiometabolic risk factors that influences mortality globally. Unraveling the causality between blood lipids and metabolites and the complex networks connecting lipids, metabolites, and other cardiometabolic tr…
View article: Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study
Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study Open
Epigenetic clocks based on DNA methylation have been known as biomarkers of aging, including principal component (PC) clocks representing the degree of aging and DunedinPACE representing the pace of aging. Prior studies have shown the asso…
View article: Predictive value of 8-year blood pressure measures in intracerebral haemorrhage risk over 5 years
Predictive value of 8-year blood pressure measures in intracerebral haemorrhage risk over 5 years Open
Aims The relationships between long-term blood pressure (BP) measures and intracerebral haemorrhage (ICH), as well as their predictive ability on ICH, are unclear. In this study, we aim to investigate the independent associations of multip…
View article: Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population
Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population Open
National Natural Science Foundation of China, Kadoorie Charitable Foundation Hong Kong, UK Wellcome Trust, National Key R&D Program of China, Chinese Ministry of Science and Technology.
View article: A wide landscape of morbidity and mortality risk associated with marital status in 0.5 million Chinese men and women: a prospective cohort study
A wide landscape of morbidity and mortality risk associated with marital status in 0.5 million Chinese men and women: a prospective cohort study Open
The National Natural Science Foundation of China, the Kadoorie Charitable Foundation, the National Key R&D Program of China, the Chinese Ministry of Science and Technology, and the UK Wellcome Trust.
View article: Minimal improvement in coronary artery disease risk prediction in Chinese population using polygenic risk scores: evidence from the China Kadoorie Biobank
Minimal improvement in coronary artery disease risk prediction in Chinese population using polygenic risk scores: evidence from the China Kadoorie Biobank Open
Background: Several studies have reported that polygenic risk scores (PRSs) can enhance risk prediction of coronary artery disease (CAD) in European populations. However, research on this topic is far from sufficient in non-European countr…
View article: The Prospective Associations of Egg Consumption with the Risk of Total Cerebrovascular Disease Morbidity among Chinese Adults
The Prospective Associations of Egg Consumption with the Risk of Total Cerebrovascular Disease Morbidity among Chinese Adults Open
Background: Studies investigating the relationship between egg consumption and the risk of cerebrovascular disease (CED) have yielded inconsistent results. This study evaluated the association between egg consumption and the risk of CED am…
View article: Famine exposure in early life and type 2 diabetes in adulthood: findings from prospective studies in China
Famine exposure in early life and type 2 diabetes in adulthood: findings from prospective studies in China Open
ClinicalTrials.gov Identifier: NCT01053195.
View article: Cardiometabolic Traits in Adult Twins: Heritability and BMI Impact with Age
Cardiometabolic Traits in Adult Twins: Heritability and BMI Impact with Age Open
Background: The prevalence of obesity and cardiometabolic diseases continues to rise globally and obesity is a significant risk factor for cardiometabolic diseases. However, to our knowledge, evidence of the relative roles of genes and the…
View article: Association Between DNA Methylation and Blood Pressure: A 5-Year Longitudinal Twin Study
Association Between DNA Methylation and Blood Pressure: A 5-Year Longitudinal Twin Study Open
Background: Previous EWASs (Epigenome-Wide Association Studies) have reported hundreds of blood pressure (BP) associated 5′-cytosine-phosphate-guanine-3′ (CpG) sites. However, their results were inconsistent. Longitudinal observations on t…
View article: Longitudinal association of DNA methylation with type 2 diabetes and glycemic traits: A 5-year cross-lagged twin study
Longitudinal association of DNA methylation with type 2 diabetes and glycemic traits: A 5-year cross-lagged twin study Open
Previous cross-sectional Epigenome-Wide Association Studies (EWASs) in adults have reported hundreds of 5′-cytosine-phosphate-guanine-3′ (CpG) sites associated with type 2 diabetes mellitus (T2DM) and glycemic traits. However, the results …
View article: Longitudinal association of DNA methylation with type 2 diabetes and glycemic traits: A 5-year cross-lagged twin study
Longitudinal association of DNA methylation with type 2 diabetes and glycemic traits: A 5-year cross-lagged twin study Open
Previous cross-sectional Epigenome-Wide Association Studies (EWASs) in adults have reported hundreds of 5′-cytosine-phosphate-guanine-3′ (CpG) sites associated with type 2 diabetes mellitus (T2DM) and glycemic traits. However, the results …
View article: Longitudinal association of DNA methylation with type 2 diabetes and glycemic traits: A 5-year cross-lagged twin study
Longitudinal association of DNA methylation with type 2 diabetes and glycemic traits: A 5-year cross-lagged twin study Open
Previous cross-sectional Epigenome-Wide Association Studies (EWASs) in adults have reported hundreds of 5′-cytosine-phosphate-guanine-3′ (CpG) sites associated with type 2 diabetes mellitus (T2DM) and glycemic traits. However, the results …