Zengfang Hao
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View article: Case report: Single-cell RNA sequencing of PBMCs highlights monocyte gene expression alterations in a type A HBV-ACLF patient
Case report: Single-cell RNA sequencing of PBMCs highlights monocyte gene expression alterations in a type A HBV-ACLF patient Open
Hepatitis B Virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe complication with high fatality rates. However, the underlying mechanisms are still elusive and require further investigation. In this report, we described a c…
View article: Simultaneous occurrence of papillary thyroid carcinoma, medullary thyroid carcinoma, and lymphoma: A case report
Simultaneous occurrence of papillary thyroid carcinoma, medullary thyroid carcinoma, and lymphoma: A case report Open
Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, the coexistence of PTC and medullary thyroid carcinoma (MTC) is uncommon. While the simultaneous occurrence of both cancers with small lymphocytic lym…
View article: The HIF-1α/PKM2 Feedback Loop in Relation to EGFR Mutational Status in Lung Adenocarcinoma
The HIF-1α/PKM2 Feedback Loop in Relation to EGFR Mutational Status in Lung Adenocarcinoma Open
Different expression and clinical features of HIF-1α/PKM2 feedback loop was existed between LUAD and normal lung tissues, especially in EGFR mutational tumors, supporting the relationship between EGFR mutation and the key related proteins …
View article: Ochratoxin A-enhanced glycolysis induces inflammatory responses in human gastric epithelium cells through mTOR/HIF-1α signaling pathway
Ochratoxin A-enhanced glycolysis induces inflammatory responses in human gastric epithelium cells through mTOR/HIF-1α signaling pathway Open
Ochratoxin A (OTA) is a mycotoxin commonly found in several food commodities worldwide with potential nephrotoxic, hepatotoxic and carcinogenic effects. We previously showed for the first time that OTA treatment enhanced glycolysis in huma…
View article: Advanced primary fallopian tube cancer was found during chemotherapy for multiple myeloma: a case report and literaturereview
Advanced primary fallopian tube cancer was found during chemotherapy for multiple myeloma: a case report and literaturereview Open
Background: Multiple myeloma (MM) is a common malignant tumor of the blood system, the incidence of fallopian tube cancer is low, accounting for only 0.1%~1.8% of gynecological malignant tumors. It is extremely rare for these two diseases …
View article: Expression of HIF-1α/PKM2 axis correlates to biological and clinical significance in papillary thyroid carcinoma
Expression of HIF-1α/PKM2 axis correlates to biological and clinical significance in papillary thyroid carcinoma Open
hypoxia inducible factor-1α (HIF-1α) and pyruvate kinase M2 (PKM2) are 2 key metabolic regulatory proteins, they could engage in a positive feedback loop and drive cancer growth by enhancing glycolysis. This study aimed to investigate the …
View article: Misdiagnosis of asymptomatic intrathyroidal pyriform sinus fistula: a case report
Misdiagnosis of asymptomatic intrathyroidal pyriform sinus fistula: a case report Open
Pyriform sinus fistula is uncommon and easily misdiagnosed. Most reported cases occur in children and are associated with either acute suppurative thyroiditis or deep neck infection. Asymptomatic pyriform sinus fistula is difficult to diag…
View article: Clinical significance of AJUBA, YAP1, and MMP14 expression in esophageal squamous cell carcinoma.
Clinical significance of AJUBA, YAP1, and MMP14 expression in esophageal squamous cell carcinoma. Open
Esophageal squamous cell carcinoma (ESCC) is generally known to be a highly fatal cancer, and thus novel molecular targets are needed to improve its diagnosis and treatment. AJUBA has been shown to regulate cell cycle, adhesion, proliferat…