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View article: KRAS G12A Identifies a High-Risk Subset in Resected Stage II–III Colorectal Cancer
KRAS G12A Identifies a High-Risk Subset in Resected Stage II–III Colorectal Cancer Open
Background: KRAS mutations are detected in ~40% of colorectal cancer (CRC), yet their prognostic value is heterogeneous across specific substitutions; the impact of uncommon variants, particularly in non-metastatic disease, remains uncerta…
View article: Supplementary Data from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression
Supplementary Data from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression Open
Supplementary Table S1-S7, Suuplemntary Figure S1-S16
View article: Figure 1 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression
Figure 1 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression Open
Integration of bulk, cell line, and single-cell RNA-seq for 188 glycosyltransferase genes identified five genes that were differentially expressed between MSI and MSS colorectal cancers. A, Heatmap depicting the upregulation of GALNT7, GAL…
View article: Figure 4 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression
Figure 4 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression Open
GALNT7 depletion and IFNγ-induced PD-L1 expression in MSI colorectal cancer cell lines. LS180, HCT116, LoVo, and RKO cells transfected with siRNAs targeting GALNT7 or scramble negative control in the presence or absence of IFNγ, analyzed u…
View article: Figure 2 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression
Figure 2 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression Open
Prognostic impact of GALNT7 and the association between GALNT7 and PD-L1 (CD274) in colorectal cancer, stratified by MSI status. A–F, Kaplan–Meier curves for OS in TCGA cohort (A and D), PFS in the AC-ICAM cohort (B and E), and RFS in the …
View article: Data from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression
Data from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression Open
Colorectal cancer with deficient mismatch repair (dMMR)/microsatellite instability (MSI) constitutes a distinct clinicopathologic and immunologic subtype, characterized by high sensitivity to immune checkpoint inhibitors. However, prognosi…
View article: Figure 3 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression
Figure 3 from GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression Open
IHC for GALNT7 expression in colorectal cancer. A–C, Representative images of a case of dMMR colorectal cancer with GALNT7-Low (A), showing tumor cell PD-L1 positive (B) and lack of Tn antigen expression (C). D–F, Representative images of …
View article: The Impact of Worsening Nutritional Status in Neoadjuvant Chemotherapy on Postoperative Outcomes in Esophageal Cancer
The Impact of Worsening Nutritional Status in Neoadjuvant Chemotherapy on Postoperative Outcomes in Esophageal Cancer Open
Although NAC reduces tumor burden and eliminates micrometastases, it potentially worsens nutritional status. Chemotherapy-induced hematologic toxicities are a risk factor for this decline. Therefore, comprehensive nutritional assessment an…
View article: GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression
GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression Open
Colorectal cancer with deficient mismatch repair (dMMR)/microsatellite instability (MSI) constitutes a distinct clinicopathologic and immunologic subtype, characterized by high sensitivity to immune checkpoint inhibitors. However, prognosi…
View article: Residual Tumor Resection After Anti-PD-1 Therapy: A Promising Treatment Strategy for Overcoming Immune Evasive Phenotype Induced by Anti-PD-1 Therapy in Gastric Cancer
Residual Tumor Resection After Anti-PD-1 Therapy: A Promising Treatment Strategy for Overcoming Immune Evasive Phenotype Induced by Anti-PD-1 Therapy in Gastric Cancer Open
Background: Anti-programmed death 1 receptor (PD-1) therapy is a promising treatment strategy for patients with unresectable advanced or recurrent gastric/gastroesophageal junction (G/GEJ) cancer. However, its response rate and survival be…
View article: Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer
Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer Open
The tumor cell-intrinsic cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is critical for activating anti-tumor immunity and enhancing immune checkpoint blockade therapy in colorectal cancer (CRC). Cancer-assoc…
View article: Short-term Outcomes of Robotic Lateral Pelvic Lymph Node Dissection for Lower Rectal Cancer
Short-term Outcomes of Robotic Lateral Pelvic Lymph Node Dissection for Lower Rectal Cancer Open
Rob-LPND may reduce postoperative total drainage volume and shorten postoperative hospital stays. These improvement in short-term outcomes suggest potential clinical advantages of Rob-LPND.
View article: Cardiac tamponade caused by a ruptured coronary aneurysm treated with open-chest hemostasis after esophageal cancer surgery: a case report
Cardiac tamponade caused by a ruptured coronary aneurysm treated with open-chest hemostasis after esophageal cancer surgery: a case report Open
Cardiac tamponade is a rare postoperative complication of esophagectomy, with no previous reports of association with coronary artery aneurysm rupture. We present a case of cardiac tamponade caused by coronary aneurysm rupture following es…
View article: The ratio of intratumoral <scp>CD15</scp><sup>+</sup> neutrophils to <scp>CD8</scp><sup>+</sup> lymphocytes predicts recurrence in patients with gastric cancer after curative resection
The ratio of intratumoral <span>CD15</span><sup>+</sup> neutrophils to <span>CD8</span><sup>+</sup> lymphocytes predicts recurrence in patients with gastric cancer after curative resection Open
Background An elevated neutrophil‐to‐lymphocyte ratio (NLR) in peripheral blood is an independent prognostic indicator of various cancers. Aims In this study, we aimed to investigate the prognostic relevance of the intratumoral immune cell…
View article: TIM-3 Expression on Dendritic Cells in Colorectal Cancer
TIM-3 Expression on Dendritic Cells in Colorectal Cancer Open
TIM-3 was originally identified as a negative regulator of helper T cells and is expressed on dendritic cells (DCs). Since the inhibition of TIM-3 on DCs has been suggested to enhance T cell-mediated anti-tumor immunity, we examined its ex…
View article: Outcomes of laparoscopic and endoscopic cooperative surgery for gastric submucosal tumors: A retrospective multicenter study at 21 Japanese institutions
Outcomes of laparoscopic and endoscopic cooperative surgery for gastric submucosal tumors: A retrospective multicenter study at 21 Japanese institutions Open
Aim We conducted a multicenter study on classical laparoscopic and endoscopic cooperative surgery (LECS) and LECS‐related procedures to retrospectively clarify the safety, problems, and mid‐term outcomes of these methods after their covera…
View article: The real-world-data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: A multi- institutional cohort study
The real-world-data of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer: A multi- institutional cohort study Open
Background The real-world efficacy, feasibility, and prognostic factors of immune-checkpoint inhibitor combination therapy for unresectable or metastatic esophageal cancer are not fully established. Methods This multi-institutional retrosp…
View article: A case of gastric gastrointestinal stromal tumor with abscess resected by laparoscopic surgery
A case of gastric gastrointestinal stromal tumor with abscess resected by laparoscopic surgery Open
胃消化管間質腫瘍（gastrointestinal stromal tumor, GIST）は腫瘍径の増大に伴い内部の変性，出血，壊死をきたすことがあり，腫瘍内部の感染を呈する場合がある。症例は82歳女性。近医で施行された上部消化管内視鏡検査（esophagogastroduodenoscopy, EGD）で穹窿部に粘膜下腫瘍を指摘され，当院紹介となった。当院で施行したEGDでは穹窿部にdelleを伴う56×47mmの粘膜下腫瘍を認めた。超音波内視鏡下穿刺吸引法を施行しGI…
View article: Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer
Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer Open
Background Tumor-associated antigen (TAA)-specific CD8(+) T cells are essential for nivolumab therapy, and irradiation has been reported to have the potential to generate and activate TAA-specific CD8(+) T cells. However, mechanistic insig…
View article: TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer
TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal Cancer Open
TGFβ signaling in the tumor microenvironment (TME) drives immune evasion and is a negative predictor of immune checkpoint inhibitor (ICI) efficacy in colorectal cancer (CRC). TIM-3, an inhibitory receptor implicated in anti-tumor immune re…
View article: A Life-Saving Case of Left Common Carotid Esophagogastric Tube Fistula after Subtotal Esophagectomy
A Life-Saving Case of Left Common Carotid Esophagogastric Tube Fistula after Subtotal Esophagectomy Open
症例は75歳の男性で，2015年に食道癌に対して胸腔鏡下食道亜全摘，胸骨後経路頸部食道胃管吻合術を施行した．術後吻合部狭窄を認め，内視鏡的拡張術を頻回に施行していた．2017年，吐血で当院救急外来を受診した．左総頸動脈食道胃管吻合部瘻を来しており，一時心肺停止に陥るも，蘇生可能であり，救急外来で出血部位の直接縫合による緊急止血術を施行した．初回緊急手術から第37病日に左総頸動脈仮性瘤破裂による大量出血を来し，緊急手術を施行した．左総頸動脈に被覆ステントグラフトを留置し，食道…
View article: A Potential Biomarker of Dynamic Change in Peripheral CD45RA−CD27+CD127+ Central Memory T Cells for Anti-PD-1 Therapy in Patients with Esophageal Squamous Cell Carcinoma
A Potential Biomarker of Dynamic Change in Peripheral CD45RA−CD27+CD127+ Central Memory T Cells for Anti-PD-1 Therapy in Patients with Esophageal Squamous Cell Carcinoma Open
In order to develop a biomarker predicting the efficacy of treatments for patients with esophageal squamous cell carcinoma (ESCC), we evaluated the subpopulation of T cells in ESCC patients treated with chemotherapy (CT), chemoradiotherapy…