Zejia Sun
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View article: Uncovering Novel Susceptible Genes and Therapeutic Targets of Prostate Cancer: a Multi-omics Study Integrating Summary-based Mendelian Randomization Analysis and Molecular Docking
Uncovering Novel Susceptible Genes and Therapeutic Targets of Prostate Cancer: a Multi-omics Study Integrating Summary-based Mendelian Randomization Analysis and Molecular Docking Open
These findings provide robust leads for understanding pathogenic mechanisms and developing therapeutic interventions for PrCa.
View article: Identifying Immuno-Fibrotic Roles of Lactylation-Related T Cell Hub Genes in Renal Ischemia–Reperfusion Injury: A Multi-Omics Study and Experimental Validation
Identifying Immuno-Fibrotic Roles of Lactylation-Related T Cell Hub Genes in Renal Ischemia–Reperfusion Injury: A Multi-Omics Study and Experimental Validation Open
This multi-omics study identified a key lactylation-associated hub T cell potentially implicated in post-IRI induced maladaptive repair. Four lactylation-related T-cell biomarkers (CORO1A, HLA-E, IGHM, and TUBA1A) predicted allograft malad…
View article: AI-assisted Preoperative Planning Combined with Robotic-assisted Total Knee Arthroplasty vs. Conventional Surgery: A Retrospective Controlled Study
AI-assisted Preoperative Planning Combined with Robotic-assisted Total Knee Arthroplasty vs. Conventional Surgery: A Retrospective Controlled Study Open
Objective: To compare perioperative outcomes and early functional recovery between AI-robotic and conventional total knee arthroplasty (TKA). Methods: We retrospectively analyzed data from 88 patients who underwent primary unilateral TKA f…
View article: Comprehensive analysis of the association between volatile organic compound pollutants and chronic kidney disease in hypertensive populations: insights from multi-omics approaches and identification of potential therapeutic targets
Comprehensive analysis of the association between volatile organic compound pollutants and chronic kidney disease in hypertensive populations: insights from multi-omics approaches and identification of potential therapeutic targets Open
Environmental pollutants, including volatile organic compounds (VOCs), are increasingly linked to chronic kidney disease (CKD), yet this association in hypertensive populations is not well understood. This study used data from the National…
View article: Diverse regulated cell death patterns and immune traits in kidney allograft with fibrosis: a prediction of renal allograft failure based on machine learning, single-nucleus RNA sequencing and molecular docking
Diverse regulated cell death patterns and immune traits in kidney allograft with fibrosis: a prediction of renal allograft failure based on machine learning, single-nucleus RNA sequencing and molecular docking Open
Conclusions: In summary, this study explored the activation of nine RCD pathways and their relationships with immune traits, identified potential RCD-related hub genes associated with renal fibrosis, and highlighted potential therapeutic t…
View article: Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing
Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing Open
Background The demographic shift towards an older population presents significant challenges for kidney transplantation (KTx), particularly due to the vulnerability of aged donor kidneys to ischemic damage, delayed graft function, and redu…
View article: Identification of bladder cancer subtypes and predictive signature for prognosis, immune features, and immunotherapy based on immune checkpoint genes
Identification of bladder cancer subtypes and predictive signature for prognosis, immune features, and immunotherapy based on immune checkpoint genes Open
Immunotherapy based on immune checkpoint genes (ICGs) has recently made significant progress in the treatment of bladder cancer patients, but many patients still cannot benefit from it. In the present study, we aimed to perform a comprehen…
View article: Role of ferroptosis in fibrosis: From mechanism to potential therapy
Role of ferroptosis in fibrosis: From mechanism to potential therapy Open
Fibrosis, which is a manifestation of the physiological response to injury characterized by excessive accumulation of extracellular matrix components, is a ubiquitous outcome of the repair process. However, in cases of repetitive or severe…
View article: Frailty in kidney transplant candidates and recipients: pathogenesis and intervention strategies
Frailty in kidney transplant candidates and recipients: pathogenesis and intervention strategies Open
With the rapid aging of the global population posing a serious problem, frailty, a non-specific state that reflects physiological senescence rather than aging in time, has become more widely addressed by researchers in various medical fiel…
View article: Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study
Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study Open
BACKGROUND Delayed graft function (DGF) caused by ischemia-reperfusion injury is a common pathophysiological process that should be monitored by specific biomarkers in addition to serum creatinine. Thus, this single-center retrospective st…
View article: Identification of renal ischemia reperfusion injury subtypes and predictive strategies for delayed graft function and graft survival based on neutrophil extracellular trap-related genes
Identification of renal ischemia reperfusion injury subtypes and predictive strategies for delayed graft function and graft survival based on neutrophil extracellular trap-related genes Open
Background Ischemia reperfusion injury (IRI) is an inevitable process in renal transplantation, which is closely related to serious postoperative complications such as delayed graft function (DGF), acute rejection and graft failure. Neutro…
View article: The role of extracellular traps in ischemia reperfusion injury
The role of extracellular traps in ischemia reperfusion injury Open
In response to strong signals, several types of immune cells release extracellular traps (ETs), which are web-like structures consisting of DNA decorated with various protein substances. This process is most commonly observed in neutrophil…
View article: TGF-β Enhances Immunosuppression of Myeloid-Derived Suppressor Cells to Induce Transplant Immune Tolerance Through Affecting Arg-1 Expression
TGF-β Enhances Immunosuppression of Myeloid-Derived Suppressor Cells to Induce Transplant Immune Tolerance Through Affecting Arg-1 Expression Open
Myeloid-derived suppressor cells (MDSCs) are a class of heterogeneous myeloid cells, which play an important role in immunosuppression. We intended to find an effective method that can produce MDSCs with significantly better efficiency and…
View article: Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review
Metastatic Clear Cell Renal Cell Carcinoma to Pancreas and Distant Organs 24 Years After Radical Nephrectomy: A Case Report and Literature Review Open
Background Clear cell renal cell carcinoma (CCRCC) is a common urological neoplasm, and even though surgical resection is effective for localized CCRCC, the prognosis of metastatic CCRCC is poor. Currently, there is a paucity of recognized…
View article: Tumor-Associated Inflammation: The Tumor-Promoting Immunity in the Early Stages of Tumorigenesis
Tumor-Associated Inflammation: The Tumor-Promoting Immunity in the Early Stages of Tumorigenesis Open
Tumorigenesis is a multistage progressive oncogenic process caused by alterations in the structure and expression level of multiple genes. Normal cells are continuously endowed with new capabilities in this evolution, leading to subsequent…
View article: MSC-Derived Extracellular Vesicles Activate Mitophagy to Alleviate Renal Ischemia/Reperfusion Injury via the miR-223-3p/NLRP3 Axis
MSC-Derived Extracellular Vesicles Activate Mitophagy to Alleviate Renal Ischemia/Reperfusion Injury via the miR-223-3p/NLRP3 Axis Open
Background. MSC-derived extracellular vehicles (EVs) exhibit a protective functional role in renal ischemia/reperfusion injury (RIRI). Recent studies have revealed that mitophagy could be a potential target process in the treatment of RIRI…
View article: Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment
Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment Open
Ferroptosis is a newly proposed programmed cell death that has great potential in limiting tumor progression and malignancies that are resistant to conventional therapies. However, recent reports have shown that ferroptosis in the tumor mi…
View article: Exosomal lncRNA TUG1 Derived From Human Urine-derived Stem Cells Attenuates Renal Ischemia/reperfusion Injury by Interacting With SRSF1 to Regulate ASCL4 Mediated Ferroptosis
Exosomal lncRNA TUG1 Derived From Human Urine-derived Stem Cells Attenuates Renal Ischemia/reperfusion Injury by Interacting With SRSF1 to Regulate ASCL4 Mediated Ferroptosis Open
Background: Human urine-derived stem cells (USCs) derived exosomes protect against kidney ischemia/reperfusion injury (IRI), while the underlying mechanisms of this protective effect remain unclear. Methods: Human USCs and USCs derived exo…
View article: A Ferroptosis-Related Genes Model Allows for Prognosis and Treatment Stratification of Clear Cell Renal Cell Carcinoma: A Bioinformatics Analysis and Experimental Verification
A Ferroptosis-Related Genes Model Allows for Prognosis and Treatment Stratification of Clear Cell Renal Cell Carcinoma: A Bioinformatics Analysis and Experimental Verification Open
Introduction Clear cell renal cell carcinoma (ccRCC) is a malignant tumor characterized by poor prognosis and difficult treatment. Ferroptosis is a relatively new form of programmed cell death that involved in cancer development and therap…
View article: Additional file 7 of A promising Prognostic risk model for advanced renal cell carcinoma (RCC) with immune-related genes
Additional file 7 of A promising Prognostic risk model for advanced renal cell carcinoma (RCC) with immune-related genes Open
Additional file 7: Supplementary Table 5. _landscape_high risk group.
View article: Nephrogenic adenoma of the renal pelvis
Nephrogenic adenoma of the renal pelvis Open
Rationale: Nephrogenic adenoma (NA) is a rare benign lesion of the urinary tract, which rarely occurs in the renal pelvis. Only 19 cases have been reported in the literature. However, there is no detailed report on the clinicopathological …
View article: A zinc finger protein gene signature enables bladder cancer treatment stratification
A zinc finger protein gene signature enables bladder cancer treatment stratification Open
Bladder cancer (BC) is a commonly occurring malignant tumor affecting the urinary tract. Zinc finger proteins (ZNFs) constitute the largest transcription factor family in the human genome and are therefore attractive biomarker candidates f…
View article: A novel five-zinc finger-related-gene signature related to tumor immune microenvironment allows for treatment stratification and predicts prognosis in clear cell renal cell carcinoma patients
A novel five-zinc finger-related-gene signature related to tumor immune microenvironment allows for treatment stratification and predicts prognosis in clear cell renal cell carcinoma patients Open
Background Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent renal malignant tumors, which survival rate and quality of life of ccRCC patients are not satisfactory. Therefore, identification of prognostic biomarkers of c…