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View article: Poly (ADP‐Ribose) Glycohydrolase‐Dependent dePARylation of PCNA Is Essential for DNA Replication
Poly (ADP‐Ribose) Glycohydrolase‐Dependent dePARylation of PCNA Is Essential for DNA Replication Open
Poly (ADP‐ribosyl)ation (PARylation) plays a crucial role in DNA replication, particularly during S phase, where it is detected at replication sites on the lagging strand to facilitate Okazaki fragment processing. However, the role of dePA…
View article: The Associations Among Gut Microbiota, Branched Chain Amino Acids, and Parkinson’s Disease: Mendelian Randomization Study
The Associations Among Gut Microbiota, Branched Chain Amino Acids, and Parkinson’s Disease: Mendelian Randomization Study Open
Background: In experimental and observational studies, the characteristics of gut microbiota have been associated with Parkinson’s disease (PD), among which metabolic pathways played an important role. However, the causality remained uncle…
View article: Modified human skin cell isolation protocol and its influence on keratinocyte and melanocyte culture
Modified human skin cell isolation protocol and its influence on keratinocyte and melanocyte culture Open
INTRODUCTION: With the increasing emphasis on the use of nonanimal ingredients in clinical care, studies have proposed the use of TrypLE™ as an alternative to trypsin. However, previous research has reported insufficient cell yield and via…
View article: Phase separation of SPIN1 through its IDR facilitates histone methylation readout and tumorigenesis
Phase separation of SPIN1 through its IDR facilitates histone methylation readout and tumorigenesis Open
Spindlin1 (SPIN1) is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription, chromosome segregation, and tumorigenesis. However, the function of the extended N-terminal region of SPIN1 remains unc…
View article: <scp>RNF167</scp> ‐mediated ubiquitination of Tollip inhibits <scp>TNF‐α</scp> ‐triggered <scp>NF‐κB</scp> and <scp>MAPK</scp> activation
<span>RNF167</span> ‐mediated ubiquitination of Tollip inhibits <span>TNF‐α</span> ‐triggered <span>NF‐κB</span> and <span>MAPK</span> activation Open
Toll‐interacting protein (Tollip) is a multifunctional regulator in cellular activities. However, whether its functions are subjected to post‐translational modifications remains elusive. Here, we identified ubiquitination as a post‐transla…
View article: [Effects and mechanism of glycine on rat cardiomyocytes pretreated with serum from burned rats].
[Effects and mechanism of glycine on rat cardiomyocytes pretreated with serum from burned rats]. Open
Objective: To investigate the effect and mechanism of glycine on rat cardiomyocytes pretreated with serum from burned rats (hereinafter referred to as burn serum). Methods: Experimental research methods were adopted. Thirty gender equally …