Zu‐Yao Yang
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View article: Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring
Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring Open
Sleep deprivation (SD) is a common issue among pregnant women. Maternal SD led to adverse effects on offspring health such as cognitive impairment through dysregulated metabolic pathways. However, it remains unknown whether maternal SD inc…
View article: Cardiomyocyte USP20 alleviates septic cardiomyopathy by deubiquitinating and inhibiting NLRP3 activity
Cardiomyocyte USP20 alleviates septic cardiomyopathy by deubiquitinating and inhibiting NLRP3 activity Open
Objectives Although extensive research on septic cardiomyopathy has been conducted, effective therapies are still limited. Ubiquitin‐specific peptidase 20 (USP20), a deubiquitinating enzyme, is critical in regulating protein ubiquitination…
View article: Contributions of 2‐h post‐load glucose, fasting blood glucose and glycosylated haemoglobin elevations to the prevalence of diabetes and pre‐diabetes in adults: A systematic analysis of global data
Contributions of 2‐h post‐load glucose, fasting blood glucose and glycosylated haemoglobin elevations to the prevalence of diabetes and pre‐diabetes in adults: A systematic analysis of global data Open
Aims Some studies found that the association of fasting blood glucose (FPG) or glycosylated haemoglobin (HbA1c) elevation with diabetic complications was not statistically significant after controlling for the confounding caused by 2‐h pos…
View article: 029 Long-term change of blood pressure and risk of major cardiovascular disease in middle-aged and older adults with prehypertension who did not take blood pressure-lowering drugs: an analysis of data from two prospective cohorts
029 Long-term change of blood pressure and risk of major cardiovascular disease in middle-aged and older adults with prehypertension who did not take blood pressure-lowering drugs: an analysis of data from two prospective cohorts Open
View article: 028 Rates and determinants of regression to normoglycemia and progression to diabetes in Chinese adults with prediabetes who did not receive glucose-lowering drug treatment: evidence from a cohort study
028 Rates and determinants of regression to normoglycemia and progression to diabetes in Chinese adults with prediabetes who did not receive glucose-lowering drug treatment: evidence from a cohort study Open
View article: Lipid-lowering drug treatment and mortality among individuals ≥75 years without cardiovascular disease: a population-based cohort study
Lipid-lowering drug treatment and mortality among individuals ≥75 years without cardiovascular disease: a population-based cohort study Open
Aims Lipid-lowering drugs are commonly prescribed for prevention of cardiovascular disease (CVD), but their efficacy in people aged ≥75 years is less understood. This population-based cohort study aimed to examine the association of lipid-…
View article: “Inconsistency between words and deeds”: a meta-analysis of the moderating and mediating mechanisms of bridging the exercise-intentional-behavior gap
“Inconsistency between words and deeds”: a meta-analysis of the moderating and mediating mechanisms of bridging the exercise-intentional-behavior gap Open
Exercise intention is a crucial predictor of exercise behavior; however, the existence of the “intention-behavior gap” is an undeniable fact, and the strength and mechanisms of their relationship remain controversial. This study, based on …
View article: Association of Screenings for Hypertension, Diabetes, and High Cholesterol With All‐Cause and Cardiovascular Mortality: Evidence From a Cohort Study
Association of Screenings for Hypertension, Diabetes, and High Cholesterol With All‐Cause and Cardiovascular Mortality: Evidence From a Cohort Study Open
Screenings for hypertension, diabetes, and high cholesterol are widely conducted in routine clinical practice for cardiovascular disease (CVD) prevention. However, few studies have investigated whether these screenings could eventually lea…
View article: Combined mind–body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial
Combined mind–body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment in primary care: a three-arm randomised controlled trial Open
Health and Medical Research Fund.
View article: Comparing the Risk of Epilepsy in Patients With Simple Congenital Heart Diseases: A Prospective Cohort Study
Comparing the Risk of Epilepsy in Patients With Simple Congenital Heart Diseases: A Prospective Cohort Study Open
Aims Simple congenital heart diseases (CHD) are associated with various central nervous system diseases, including epilepsy. This study aimed to compare the risk of epilepsy in patients with different types of simple CHD. Methods In this p…
View article: Cardiomyocyte-Derived Usp20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of Sting and Mitigating Sting-Mediated Inflammation
Cardiomyocyte-Derived Usp20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of Sting and Mitigating Sting-Mediated Inflammation Open
View article: Independent Association of Individual Lipid Abnormalities with Cardiovascular All-cause Mortality: A Prospective Cohort Study
Independent Association of Individual Lipid Abnormalities with Cardiovascular All-cause Mortality: A Prospective Cohort Study Open
View article: Prevalence of and factors associated with lipid screening in young people aged 16– to 21 years in the United States: analysis of nationwide cross-sectional data
Prevalence of and factors associated with lipid screening in young people aged 16– to 21 years in the United States: analysis of nationwide cross-sectional data Open
Background & Aims There is no consensus on whether it is worthwhile for young people to undergo lipid screening. An estimate of the national prevalence of lipid screening in this population can serve as a basic parameter in analyses of the…
View article: Definitions of chronic disease need to be more patient centred
Definitions of chronic disease need to be more patient centred Open
Early, small abnormal changes should be defined as disease only if there are effective interventions that can make an important difference to patients, argue Zu-Yao Yang and Jin-Ling Tang
View article: Estimating the Proportion of Overdiagnosis among Prostate, Breast, and Thyroid Cancers in China: Findings from the Global Burden of Disease 2019
Estimating the Proportion of Overdiagnosis among Prostate, Breast, and Thyroid Cancers in China: Findings from the Global Burden of Disease 2019 Open
The incidence of prostate, breast, and thyroid cancers has increased in China over the past few decades. Whether and how much these increases can be attributed to overdiagnosis are less understood. This study aimed to estimate the proporti…
View article: Risk of Cardiovascular Events in Adults Aged 40 to 79 Years with Diagnosed Hypertension, High Cholesterol, and/or Diabetes but Not on Medications: Findings from Nationwide Cross-Sectional Studies
Risk of Cardiovascular Events in Adults Aged 40 to 79 Years with Diagnosed Hypertension, High Cholesterol, and/or Diabetes but Not on Medications: Findings from Nationwide Cross-Sectional Studies Open
Many people with diagnosed hypertension, high cholesterol, and/or diabetes are not receiving drug treatment, partly because they perceive their cardiovascular disease (CVD) risk as low. This study aimed to quantify the risk for future CVD …
View article: Excess risks of long COVID symptoms compared with identical symptoms in the general population: A systematic review and meta-analysis of studies with control groups
Excess risks of long COVID symptoms compared with identical symptoms in the general population: A systematic review and meta-analysis of studies with control groups Open
PROSPERO (CRD42023409847).
View article: The Effect of Walking on Depressive and Anxiety Symptoms: Systematic Review and Meta-Analysis
The Effect of Walking on Depressive and Anxiety Symptoms: Systematic Review and Meta-Analysis Open
Background Previous literature lacks summative information on the mental health benefits achieved from different forms of walking. Objective The aim of this study was to assess the effectiveness of different forms of walking in reducing sy…
View article: Remission to normal blood pressure in older adults with hypertension who did not receive antihypertensive medication: analysis of data from two longitudinal cohorts
Remission to normal blood pressure in older adults with hypertension who did not receive antihypertensive medication: analysis of data from two longitudinal cohorts Open
The Chinese University of Hong Kong (7106452; 7105959),Shenzhen Science and Technology Program (KQTD20190929172835662), Strategic Priority Research Program of Chinese Academy of Sciences (XDB 38040200), National Institute on Aging (R01AG01…
View article: Overlapping Pattern of the Four Individual Components of Dyslipidemia in Adults: Analysis of Nationally Representative Data
Overlapping Pattern of the Four Individual Components of Dyslipidemia in Adults: Analysis of Nationally Representative Data Open
Background/Objectives: Dyslipidemia is a well-established risk factor for cardiovascular disease (CVD). However, among available drug treatments, only those targeted at lowering LDL-C and consequently TC have demonstrated efficacy in preve…
View article: Association of non-selective β blockers with the development of renal dysfunction in liver cirrhosis: a systematic review and meta-analysis
Association of non-selective β blockers with the development of renal dysfunction in liver cirrhosis: a systematic review and meta-analysis Open
NSBBs may not be associated with the development of renal dysfunction in liver cirrhosis. However, more evidence is required to clarify their association in specific populations.
View article: Overlapping pattern of the four individual components of dyslipidemia in adults: analysis of nationwide cross-sectional data
Overlapping pattern of the four individual components of dyslipidemia in adults: analysis of nationwide cross-sectional data Open
Background Dyslipidemia, including abnormalities in any one of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) is a well-recognized risk factor for c…
View article: Effect of anti-diabetic drugs in primary prevention of cardiovascular disease in type 2 diabetes and prediabetes: A systematic review and meta-analysis of randomized trials
Effect of anti-diabetic drugs in primary prevention of cardiovascular disease in type 2 diabetes and prediabetes: A systematic review and meta-analysis of randomized trials Open
View article: Relative effectiveness and durability of booster doses of SARS-CoV-2 vaccines: A systematic review and meta-analysis
Relative effectiveness and durability of booster doses of SARS-CoV-2 vaccines: A systematic review and meta-analysis Open
Billions of people worldwide have received booster doses of SARS-CoV-2 vaccines. Continuous monitoring of the relative vaccine effectiveness (rVE) and durability of booster vaccination over previous vaccinations is important for developing…
View article: Association of non-selective β blockers with the development of renal dysfunction in liver cirrhosis: a systematic review and meta-analysis
Association of non-selective β blockers with the development of renal dysfunction in liver cirrhosis: a systematic review and meta-analysis Open
Non-selective β blockers (NSBBs) may negatively influence renal function through decreasing heart rate and cardiac output. This study aimed to systematically investigate their association. PubMed, EMBASE, and Cochrane library databases wer…
View article: Significant myopic shift over time: Sixteen-year trends in overall refraction and age of myopia onset among Chinese children, with a focus on ages 4-6 years
Significant myopic shift over time: Sixteen-year trends in overall refraction and age of myopia onset among Chinese children, with a focus on ages 4-6 years Open
We found an overall myopic shift in SERE in Chinese children aged 4-18 years over the past 16 years, particularly in those aged 4-6 years. The mean age of myopia onset decreased by three years over the same period. The "safety threshold" o…
View article: Supplementary Figure S13 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Supplementary Figure S13 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort Open
Supplementary Figure S13 shows subgroup analyses for the association between glucosamine use and incidence of cervical cancer in female participants.
View article: Supplementary Figure S10 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Supplementary Figure S10 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort Open
Supplementary Figure S10 shows subgroup analyses for the association between glucosamine use and incidence of pancreas cancer.
View article: Supplementary Table S4 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Supplementary Table S4 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort Open
Supplementary Table S4 shows baseline characteristics of all participants by cancer diagnosis.
View article: Supplementary Figure S15 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort
Supplementary Figure S15 from Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort Open
Supplementary Figure S15 shows subgroup analyses for the association between glucosamine use and incidence of other male cancer.