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View article: 177 DNA damage repair family genomic alterations as a predictive biomarker for response to immune checkpoint inhibitors in multiple cancers
177 DNA damage repair family genomic alterations as a predictive biomarker for response to immune checkpoint inhibitors in multiple cancers Open
View article: Table S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Differentially Expressed Peptides in LiP-SMap
View article: Figure S6 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S6 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
PEP enhances glycolysis via glycolytic enzyme stabilization and activation
View article: Figure S7 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S7 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
The TGFβ/SMAD3/KHDRBS1 axis promotes SLK exon skipping
View article: Table S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Expression matrix of Alternative splicing pathway in ICGC sample
View article: Table S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
U-13C-glucose–Metabolic Flux analysis in MHCC-97H-SLKv and MHCC-97H-Vector cell lines.
View article: Figure S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Identification of SLKv promote glycolysis in H3B-8800 responded splicing events
View article: Table S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Metabolite expression matrix in MHCC-97H cells treated with either DMSO or H3B-8800
View article: Figure S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Exon skipping of SLK promotes PEP accumulation and predicts poor prognosis
View article: Figure S8 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S8 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
SLK-targeting ASO inhibits tumor growth and glycolysis
View article: Figure S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
The splicing inhibitor H3B-8800 modulates tumor glycolysis and TCA cycle
View article: Figure S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
SLKv activates tumor glycolysis in an ENO1-dependent manner
View article: Figure S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
S2-ENO1ph promotes glycolysis and PEP synthesis via dimerization
View article: Data from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Data from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
RNA splicing is frequently dysregulated in tumors. Aberrant RNA splicing can alter tumor metabolism, highlighting the need to elucidate the alternative splicing events that shape the metabolic landscape. In this study, we identified exon s…
View article: Table S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Primer and ASO sequences
View article: Soft Tissue Augmentation For Aesthetic Zone Implant Complications
Soft Tissue Augmentation For Aesthetic Zone Implant Complications Open
Introduction: The success of anterior dental implants relies on high survival rates and long-lasting aesthetic outcomes. Common aesthetic challenges include gingival recession, papillae loss, and implant platform exposure, which demand eff…
View article: Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders
Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders Open
Chronic subjective tinnitus (CST) is frequently accompanied by anxiety and sleep disturbances, together forming a self-reinforcing cycle that significantly impairs patients' quality of life and complicates clinical management. This narrati…
View article: Experience of Symptoms Related to Dysarthria in Patients with NPC During Radiotherapy: A Descriptive Qualitative Study
Experience of Symptoms Related to Dysarthria in Patients with NPC During Radiotherapy: A Descriptive Qualitative Study Open
This study helps to elucidate the current status of dysarthria faced by patients undergoing radiotherapy for NPC and provides multiple dimensions of dysarthria assessment and management goals for quantitative research. We call attention to…
View article: Value of circulating free DNA methylation in the diagnosis of esophageal cancer: A systematic review and meta‑analysis
Value of circulating free DNA methylation in the diagnosis of esophageal cancer: A systematic review and meta‑analysis Open
Liquid biopsy using circulating biomarkers has shown growing potential in cancer detection. The aim of the present study was to assess the application value of detecting the methylation level of circulating free (cf)DNA in the identificati…
View article: Photo-induced hydrous organic aggregates for photoactivatable luminescence
Photo-induced hydrous organic aggregates for photoactivatable luminescence Open
View article: Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma
Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma Open
Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing tradi…
View article: Harnessing Photocycloreversion for Dimer Construction and Photoactivation: From Molecule to Aggregate
Harnessing Photocycloreversion for Dimer Construction and Photoactivation: From Molecule to Aggregate Open
Despite extensive investigations into photophysics at the molecular level, the complex interplays between intermolecular interactions, hierarchical assembly, and photoluminescence properties remain a fundamental challenge in materials scie…
View article: In-Solution Intramolecular Through-Space Conjugations of Sterically Constrained Tetranaphthylethane
In-Solution Intramolecular Through-Space Conjugations of Sterically Constrained Tetranaphthylethane Open
View article: Cancer stem cells and niches: challenges in immunotherapy resistance
Cancer stem cells and niches: challenges in immunotherapy resistance Open
View article: Prediction of Potential Habitat Distributions and Climate Change Impacts on the Rare Species Woonyoungia septentrionalis (Magnoliaceae) in China Based on MaxEnt
Prediction of Potential Habitat Distributions and Climate Change Impacts on the Rare Species Woonyoungia septentrionalis (Magnoliaceae) in China Based on MaxEnt Open
Changes in species’ habitats provide important insights into the effects of climate change. Woonyoungia septentrionalis, a critically endangered species endemic to karst ecosystems, has a highly restricted distribution and is a key biologi…
View article: Diversity and Geographic Distribution Patterns of Wild Magnoliaceae Species in China
Diversity and Geographic Distribution Patterns of Wild Magnoliaceae Species in China Open
Magnoliaceae, an ancient lineage of relict plants, were once extensively distributed throughout geological history. Understanding their species diversity, geographic distribution patterns, and hotspots is essential for providing a theoreti…
View article: Effects of self-management interventions based on the COM-B model on peri-implant condition in older adults with periodontitis: a randomized controlled trial
Effects of self-management interventions based on the COM-B model on peri-implant condition in older adults with periodontitis: a randomized controlled trial Open
The randomized controlled clinical trial was registered on Chinese Clinical Trial Registry (No. ChiCTR2400082660, Date: 03/04/2024).
View article: Actin like 6A is a prognostic biomarker and associated with immune cell infiltration in cancers
Actin like 6A is a prognostic biomarker and associated with immune cell infiltration in cancers Open
Purpose To investigate the role of Actin like 6 A (ACTL6A) in cancer and explore the potential mechanism of its function. Methods Differential expression of ACTL6A was analyzed using Oncomine and TIMER database. Then, we downloaded data se…
View article: Regulator of nonsense transcripts 3B is a prognostic biomarker and associated with immune cell infiltration in lung squamous cell and hepatocellular carcinoma
Regulator of nonsense transcripts 3B is a prognostic biomarker and associated with immune cell infiltration in lung squamous cell and hepatocellular carcinoma Open
Purpose The characteristic of RENT3B in cancer remains ambiguous. We aimed to study the relationship between RENT3B and immune infiltration in liver hepatocellular carcinoma (LIHC) and lung squamous cell carcinoma (LUSC). Patients and meth…
View article: Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation
Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation Open
Background N4‐acetylcytidine (ac4C) represents a novel messenger RNA (mRNA) modification, and its associated acetyltransferase N‐acetyltransferase 10 (NAT10) plays a crucial role in the initiation and progression of tumors by regulating mR…