Zhanzheng Zhao
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View article: Development of risk-prediction tool for peritoneal dialysis related peritonitis and external validation in the PDTAP cohort
Development of risk-prediction tool for peritoneal dialysis related peritonitis and external validation in the PDTAP cohort Open
View article: Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway
Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway Open
Dapagliflozin (DAPA), an SGLT-2 inhibitor, shows peritoneal protection and can alleviate high glucose-induced peritoneal fibrosis. Yet, its precise molecular mechanism is unknown. This study aims to explore DAPA's protective effect on the …
View article: Glycosylation-Related Genes and Prognostic Signatures in Diabetic Nephropathy
Glycosylation-Related Genes and Prognostic Signatures in Diabetic Nephropathy Open
This study highlights the significant role of glycosylation-related genes in DN pathogenesis, likely mediated through immune and inflammatory mechanisms. VCAN, GCNT3, and GALNT7 show particular promise as novel biomarkers for clinical diag…
View article: Research on the transformation strategy of scientific and technological achievements of Suzhou's new R&D institutions based on SWOT analysis
Research on the transformation strategy of scientific and technological achievements of Suzhou's new R&D institutions based on SWOT analysis Open
The transformation of scientific and technological achievements is a key path to accelerating the cultivation and development of new productivity and a crucial link in the integration of science, technology, and the economy. This article, …
View article: The association between empirical antibiotic regimens and the outcome of peritoneal dialysis-related peritonitis: a multi-center, large-scale cohort study
The association between empirical antibiotic regimens and the outcome of peritoneal dialysis-related peritonitis: a multi-center, large-scale cohort study Open
Background Peritoneal dialysis (PD)-related peritonitis is a common complication with high morbidity and mortality, and empirical antibiotic regimens vary across countries. Despite some research, inconsistent results and design limitations…
View article: Associations between statins and all-cause mortality and cardiovascular events among peritoneal dialysis patients: A multi-center large-scale cohort study
Associations between statins and all-cause mortality and cardiovascular events among peritoneal dialysis patients: A multi-center large-scale cohort study Open
View article: Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy
Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy Open
View article: Epstein Barr virus antibody and cancer risk in two prospective cohorts in Southern China
Epstein Barr virus antibody and cancer risk in two prospective cohorts in Southern China Open
Epstein-Barr virus (EBV) has been implicated in several human cancers, but its broader cancer risk remains unclear. We investigated the association between EBV VCA-IgA antibody levels and cancer risk in two large prospective cohorts from S…
View article: Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis
Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis Open
Background: An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges. Methods: In this phase II trial, patients received Gamma Knife SBRT combined wi…
View article: Author response: Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis
Author response: Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis Open
View article: Efficacy and safety of HSK21542 for pruritus management in hemodialysis patients: a multicenter, randomized, double-blind, placebo-controlled trial
Efficacy and safety of HSK21542 for pruritus management in hemodialysis patients: a multicenter, randomized, double-blind, placebo-controlled trial Open
Background Chronic kidney disease-associated pruritus (CKD-aP) is a common and distressing symptom in hemodialysis patients. This Phase II trial evaluated the efficacy and safety of HSK21542, a selective kappa-opioid receptor agonist, in m…
View article: Clinical and pathological features of patients with recurrent anti-glomerular basement membrane disease
Clinical and pathological features of patients with recurrent anti-glomerular basement membrane disease Open
Anti-glomerular basement membrane disease (anti-GBM disease) is a rare autoimmune disease, traditionally considered a monophasic autoimmune disorder, but more and more cases of recurrence have been reported. Through a review of the publish…
View article: Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in hpMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis
Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in hpMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis Open
An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges.In this phase II trial, patients received Gamma Knife SBRT combined with Tislelizumab. P Bio…
View article: Author response: Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in hpMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis
Author response: Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in hpMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis Open
View article: Integration of transcriptome-wide association study and gene-based association analysis identifies candidate genes for Hodgkin lymphoma
Integration of transcriptome-wide association study and gene-based association analysis identifies candidate genes for Hodgkin lymphoma Open
View article: Oral microbiota signature predicts the prognosis of colorectal carcinoma
Oral microbiota signature predicts the prognosis of colorectal carcinoma Open
View article: EM-DeepSD: A Deep Neural Network Model Based on Cell-Free DNA End-Motif Signal Decomposition for Cancer Diagnosis
EM-DeepSD: A Deep Neural Network Model Based on Cell-Free DNA End-Motif Signal Decomposition for Cancer Diagnosis Open
Background and Objectives: The accurate discrimination between patients with and without cancer using their cell-free DNA (cfDNA) is crucial for early cancer diagnosis. The end-motifs of cfDNA serve as significant cancer biomarkers, offeri…
View article: Construction and validation of a predictive model for malignant tumors in patients with membranous nephropathy
Construction and validation of a predictive model for malignant tumors in patients with membranous nephropathy Open
In this largest cohort to date of MN patients with malignant tumors, a predictive model was constructed using pathological parameters to estimate the risk of malignancy effectively. This tool aims to assist clinicians in decision-making an…
View article: Comparing estimated protein excretion rate and spot urinary protein-creatinine ratio in assessing urinary protein excretion in patients with kidney disease in China: a single center study
Comparing estimated protein excretion rate and spot urinary protein-creatinine ratio in assessing urinary protein excretion in patients with kidney disease in China: a single center study Open
Objectives This study aimed to analyze the potential of the estimated protein excretion rate (ePER) as a substitute for the spot urinary protein-creatinine ratio (uPCR) in clinical reports for accurately assessing urinary protein excretion…
View article: Clinicopathological features and predictors of anti-GBM disease combined with membranous nephropathy
Clinicopathological features and predictors of anti-GBM disease combined with membranous nephropathy Open
Background Anti–glomerular basement membrane (anti-GBM) disease is a rare and life-threatening form of small vessel vasculitis that primarily affects the kidneys and lungs. In rare cases, it occurs with membranous nephropathy (MN). This st…
View article: Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis
Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis Open
Background: An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges. Methods: In this phase II trial, patients received Gamma Knife SBRT combined wi…
View article: Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis
Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis Open
An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges.In this phase II trial, patients received Gamma Knife SBRT combined with Tislelizumab. P Bio…
View article: Author response: Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis
Author response: Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis Open
View article: Examining The Effect of Bikeshare-Integrated Transit-Oriented Development on Job Accessibility and Spatial Inequality: A Case Study of Shenzhen, China
Examining The Effect of Bikeshare-Integrated Transit-Oriented Development on Job Accessibility and Spatial Inequality: A Case Study of Shenzhen, China Open
View article: Associations between iron markers with hemoglobin and outcomes in peritoneal dialysis patients: results from the PDTAP study
Associations between iron markers with hemoglobin and outcomes in peritoneal dialysis patients: results from the PDTAP study Open
Background and hypothesis Iron metabolism markers, such as transferrin saturation (TSAT) and ferritin, are crucial in anemia management in patients with CKD and those undergoing dialysis, yet optimal levels remain unelucidated. Methods We …
View article: Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand
Comparative risk of type 2 diabetes development between women with gestational diabetes and women with impaired glucose tolerance over two decades: a multiethnic prospective cohort in New Zealand Open
Introduction To evaluate the long-term risk of developing type 2 diabetes (T2D) among women with a history of gestational diabetes mellitus (GDM) compared with those with impaired glucose tolerance (IGT). Research design and methods Using …
View article: Association between within-target risk factors and life expectancy free from cardiovascular disease, cancer, and dementia in individuals with type 2 diabetes in New Zealand between 1994 and 2018: a multi-ethnic cohort study
Association between within-target risk factors and life expectancy free from cardiovascular disease, cancer, and dementia in individuals with type 2 diabetes in New Zealand between 1994 and 2018: a multi-ethnic cohort study Open
Having multiple WTRF + at baseline is associated with a considerable increase in life expectancy free from major chronic disease among individuals with T2D. This highlights the importance of lifestyle and clinical interventions in the mana…
View article: Prognostic value of serum complement cleavage factor Bb in idiopathic membranous nephropathy and establishment of nomogram model
Prognostic value of serum complement cleavage factor Bb in idiopathic membranous nephropathy and establishment of nomogram model Open
View article: OTUB1 regulation of ferroptosis and the protective role of ferrostatin-1 in lupus nephritis
OTUB1 regulation of ferroptosis and the protective role of ferrostatin-1 in lupus nephritis Open
Lupus nephritis (LN) is a prevalent and severe manifestation of systemic lupus erythematosus (SLE), leading to significant morbidity and mortality. OTUB1, a deubiquitinating enzyme, has emerged as a potential therapeutic target due to its …
View article: Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis
Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis Open
Background An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges. Methods In this phase II trial, patients received Gamma Knife SBRT combined with…