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View article: Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human
Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human Open
Age increases of brain amyloid plaques may be mediated by prior increase of soluble Aβ42. Here, we show that frontal cortex samples from brains of cognitively normal aging humans had progressively increased levels of soluble amyloid peptid…
View article: Rapid boundary stabilization of 1D nonlinear parabolic equations
Rapid boundary stabilization of 1D nonlinear parabolic equations Open
In this paper, we focus on the rapid boundary stabilization of 1D nonlinear parabolic equations via the modal decomposition method. The nonlinear term is assumed to satisfy certain local Lipschitz continuity and global growth conditions. T…
View article: Dual metabolic-inflammation modulation in MicroRNA@neutrophil-derived microvesicles achieve robust osteoarthritis therapy
Dual metabolic-inflammation modulation in MicroRNA@neutrophil-derived microvesicles achieve robust osteoarthritis therapy Open
View article: Efficacy of bevacizumab maintenance therapy in advanced ovarian cancer
Efficacy of bevacizumab maintenance therapy in advanced ovarian cancer Open
This study aimed to evaluate the efficacy of bevacizumab maintenance therapy in advanced ovarian cancer and its impact on the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3)/vascular endothelial growth fact…
View article: Small patients, significant findings: Electrophysiological properties of Bachmann’s bundle in pediatric patients
Small patients, significant findings: Electrophysiological properties of Bachmann’s bundle in pediatric patients Open
In pediatric patients with CHD, BB already contains a considerable amount of conduction disorders, LVAs, and potentials with complex morphology. The prevalence of these early electrophysiological alterations is not age related and does not…
View article: Male-Biased Cyp17a2 Governs Antiviral Sexual Dimorphism in Fish via STING Stabilization and Viral Protein Degradation
Male-Biased Cyp17a2 Governs Antiviral Sexual Dimorphism in Fish via STING Stabilization and Viral Protein Degradation Open
Differences in immunity between males and females in living organisms are generally thought to be due to sex hormones and sex chromosomes, and it is often assumed that males have a weaker immune response. Here we report that in fish, males…
View article: Subacute ruminal acidosis induces hepatic injury in dairy goats via oxidative stress and ferritinophagy-ferroptosis axis
Subacute ruminal acidosis induces hepatic injury in dairy goats via oxidative stress and ferritinophagy-ferroptosis axis Open
Increasing the proportion of high-concentrate feed in ruminant diets can rapidly enhance milk production and overall performance. Prolonged feeding of high-concentrate (HC) diet may reduce ruminal pH, potentially inducing subacute rumen ac…
View article: Sialyltransferase-related genes as predictive factors for therapeutic response and prognosis in cervical cancer
Sialyltransferase-related genes as predictive factors for therapeutic response and prognosis in cervical cancer Open
Background Cancer-associated hypersialylation is believed to be related to the metastatic cell phenotype and the suppression of sialyltransferases (SiaTs) has been suggested to be a potent preventive strategy against metastasis. The presen…
View article: An opinion on the roles of phenylalanine ammonia-lyase in the browning of fresh-cut fruit and vegetables
An opinion on the roles of phenylalanine ammonia-lyase in the browning of fresh-cut fruit and vegetables Open
View article: Correction: Anterior lumbar discectomy and fusion: an effective technique in treating lumbar disc herniation—— a retrospective case study
Correction: Anterior lumbar discectomy and fusion: an effective technique in treating lumbar disc herniation—— a retrospective case study Open
View article: Association of systemic inflammatory biomarkers with ocular disease: a large population-based cross-sectional study
Association of systemic inflammatory biomarkers with ocular disease: a large population-based cross-sectional study Open
Two new systemic inflammatory biomarkers, SII index and SIRI, are closely related to the risk of eye disease. There are different associations between SII index and different ocular diseases. This should raise more concerns and lead to bet…
View article: The membrane may be a key factor influencing browning: a mini review on browning mechanisms of fresh-cut fruit and vegetables from a multi-omics perspective
The membrane may be a key factor influencing browning: a mini review on browning mechanisms of fresh-cut fruit and vegetables from a multi-omics perspective Open
Fresh-cut fruit and vegetables are susceptible to browning during storage and subsequent consumption. The cell membrane acts as a vital structural barrier, compartmentalizing various substances within living organisms. The fresh-cutting pr…
View article: Anterior lumbar discectomy and fusion: an effective technique in treating lumbar disc herniation—— a retrospective case study
Anterior lumbar discectomy and fusion: an effective technique in treating lumbar disc herniation—— a retrospective case study Open
ALDF provides an effective treatment strategy for patients with lumbar disc herniation. This procedure allows direct removal of protruding discs and calcified posterior longitudinal ligaments under the microscope, achieving the goal of dir…
View article: Association of dietary inflammatory index with ocular diseases: a population-based cross-sectional study
Association of dietary inflammatory index with ocular diseases: a population-based cross-sectional study Open
Reducing the intake of pro-inflammatory foods may be an effective measure to prevent the onset of ocular disease, including glaucoma, cataract, ARMD, and diabetic retinopathy. However, eating only anti-inflammatory foods is not the best ch…
View article: Author response: Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response
Author response: Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response Open
View article: Ap-Referv2: One Stage 3d Visual Grounding-Audio Method Based on Audio-Guided Point Cloud Sampling
Ap-Referv2: One Stage 3d Visual Grounding-Audio Method Based on Audio-Guided Point Cloud Sampling Open
View article: Attentional Bias to Food Cues among College Students with Different Levels of Positive Body Image: Evidence from Eye Movements
Attentional Bias to Food Cues among College Students with Different Levels of Positive Body Image: Evidence from Eye Movements Open
View article: Moisture Sorption Thermodynamic and Kinetic analyses of Commercial Tobacco Filaments and In-situ Prediction
Moisture Sorption Thermodynamic and Kinetic analyses of Commercial Tobacco Filaments and In-situ Prediction Open
View article: Highly sensitive detection of diethylstilbestrol based on a dual-mode membrane sensor of molecular imprinted nanozymes
Highly sensitive detection of diethylstilbestrol based on a dual-mode membrane sensor of molecular imprinted nanozymes Open
View article: Targeting Myeloperoxidase to Reduce Neuroinflammation in X‐Linked Dystonia Parkinsonism
Targeting Myeloperoxidase to Reduce Neuroinflammation in X‐Linked Dystonia Parkinsonism Open
Aims Although the genetic locus of X‐linked dystonia parkinsonism (XDP), a neurodegenerative disease endemic in the Philippines, is well‐characterized, the exact mechanisms leading to neuronal loss are not yet fully understood. Recently, w…
View article: Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications
Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications Open
Diabetes mellitus (DM) is one of the major causes of mortality worldwide, with inflammation being an important factor in its onset and development. This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenos…
View article: Association of single nucleotide polymorphisms and gene-environment interactions with major depressive disorder in Chinese
Association of single nucleotide polymorphisms and gene-environment interactions with major depressive disorder in Chinese Open
View article: Application of Target Detection Based on Deep Learning in Intelligent Mineral Identification
Application of Target Detection Based on Deep Learning in Intelligent Mineral Identification Open
In contemporary society, rich in mineral resources, efficiently and accurately identifying and classifying minerals has become a prominent issue. Recent advancements in artificial intelligence, particularly breakthroughs in deep learning, …
View article: Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response
Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response Open
Although the classical biological protein cell cycle protein kinase CDK2 has been extensively studied in higher vertebrates, its function in lower vertebrates beyond the regulation of mitosis remains unknown. In this study, we report a dis…
View article: Statics Performance and Heat Dissipation Evaluation of Lattice Structures Prepared by Laser Powder Bed Fusion
Statics Performance and Heat Dissipation Evaluation of Lattice Structures Prepared by Laser Powder Bed Fusion Open
This paper address the performance optimization of the battery heat sink module by analyzing the lattice structure of the battery heat sink module through in-depth modeling and simulation, and combining the laser powder bed fusion (LPBF)-f…
View article: Manganese inhibits SVCV infection by promoting the expression of STING and the subsequent activation of IFN
Manganese inhibits SVCV infection by promoting the expression of STING and the subsequent activation of IFN Open
Manganese (Mn) is necessary for various biological processes, yet its function in innate immunity has been less studied, especially in fish. Stimulator of interferon (IFN) genes (STING) is an essential factor for IFN induction in virus inf…
View article: First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial
First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial Open
View article: Top stories on catheter ablation of atrial fibrillation in patients with congenital heart defects
Top stories on catheter ablation of atrial fibrillation in patients with congenital heart defects Open
View article: Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN
Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN Open
View article: Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response
Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response Open
Although the classical biological protein cell cycle protein kinase CDK2 has been extensively studied in higher vertebrates, its function in lower vertebrates beyond the regulation of mitosis remains unknown. In this study, we report a dis…