Weiwei Dai
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View article: Predicting Intraocular Collamer Lens Vault in Myopic Patients With Shallow Anterior Chamber Using FedEYE Platform and ChatGPT
Predicting Intraocular Collamer Lens Vault in Myopic Patients With Shallow Anterior Chamber Using FedEYE Platform and ChatGPT Open
Using different AI models to predict vault after ICL implantation could be of clinical significance for improving surgical safety and efficacy in shallow ACD patients.
View article: Rhein alleviates hepatic steatosis in NAFLD mice by activating the AMPK/ACC/SREBP1 pathway to enhance lipid metabolism
Rhein alleviates hepatic steatosis in NAFLD mice by activating the AMPK/ACC/SREBP1 pathway to enhance lipid metabolism Open
Background Non-alcoholic fatty liver disease (NAFLD) is a common metabolic liver disorder characterized by excessive lipid accumulation. The 5’-adenosine monophosphate-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC)/sterol reg…
View article: Topical Diclofenac Sodium and Macular Microcirculation After Phacoemulsification: A Retrospective OCTA Analysis
Topical Diclofenac Sodium and Macular Microcirculation After Phacoemulsification: A Retrospective OCTA Analysis Open
Background To evaluate the effects of perioperative 0.1% topical diclofenac sodium ophthalmic solution on macular microcirculation in patients undergoing phacoemulsification, using optical coherence tomography angiography (OCTA). Methods T…
View article: Decoding heterogeneous single-cell perturbation responses
Decoding heterogeneous single-cell perturbation responses Open
View article: OphthBench: A Comprehensive Benchmark for Evaluating Large Language Models in Chinese Ophthalmology
OphthBench: A Comprehensive Benchmark for Evaluating Large Language Models in Chinese Ophthalmology Open
Large language models (LLMs) have shown significant promise across various medical applications, with ophthalmology being a notable area of focus. Many ophthalmic tasks have shown substantial improvement through the integration of LLMs. Ho…
View article: HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma
HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma Open
Upon infection with herpes simplex virus 1 (HSV-1), the virus deploys multiple strategies to evade the host's innate immune response. However, the mechanisms governing this phenomenon remain elusive. Here, we find that HSV-1 leads to a dec…
View article: Risk Factors for Focal Choroidal Excavation Concurrent with Chorioretinal Disease: Evaluated by Spectral-Domain OCT
Risk Factors for Focal Choroidal Excavation Concurrent with Chorioretinal Disease: Evaluated by Spectral-Domain OCT Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Influence of deposition path strategy on residual stress and deformation in weaving wire-arc additive manufacturing of disc parts
Influence of deposition path strategy on residual stress and deformation in weaving wire-arc additive manufacturing of disc parts Open
Deposition pattern and path-planning deposition strategy have significant impacts on the deformation and residual stress of components during a wire-arc additive manufacturing (WAAM) process. This work comparatively addressed the influence…
View article: NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion
NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion Open
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA m…
View article: Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma
Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma Open
View article: Exploration of the effect and mechanism of Scutellaria barbata D. Don in the treatment of ovarian cancer based on network pharmacology and in vitro experimental verification
Exploration of the effect and mechanism of Scutellaria barbata D. Don in the treatment of ovarian cancer based on network pharmacology and in vitro experimental verification Open
The mortality rate of ovarian cancer is the highest among gynecological cancers, posing a serious threat to women health and life. Scutellaria barbata D. Don (SBD) can effectively treat ovarian cancer. However, its mechanism of action is u…
View article: Decoding Heterogenous Single-cell Perturbation Responses
Decoding Heterogenous Single-cell Perturbation Responses Open
Understanding diverse responses of individual cells to the same perturbation is central to many biological and biomedical problems. Current methods, however, do not precisely quantify the strength of perturbation responses and, more import…
View article: Influence of pulling direction on knot security: A laboratory research
Influence of pulling direction on knot security: A laboratory research Open
Pulling in constant direction results in inferior knot security. Surgeons must ascertain the influence of pulling direction on knot security, and try to achieve superior security with fewer throws to ensure patient safety.
View article: Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance
Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance Open
Differences in dietary fatty acid saturation impact glucose homeostasis and insulin sensitivity in vertebrates. Excess dietary intake of saturated fatty acids (SFAs) induces glucose intolerance and metabolic disorders. In contrast, unsatur…
View article: Glutamine synthetase: a tumor suppressor in hepatocellular carcinoma?
Glutamine synthetase: a tumor suppressor in hepatocellular carcinoma? Open
Glutamine ( Gln ) is the most abundant free amino acid in the circulation.In addition to being a proteinogenic amino acid, it has multifaceted functions by serving as a nitrogen and carbon donor for the biosynthesis of essential metabolite…
View article: Genome-wide CRISPR screens identify combinations of candidate latency reversing agents for targeting the latent HIV-1 reservoir
Genome-wide CRISPR screens identify combinations of candidate latency reversing agents for targeting the latent HIV-1 reservoir Open
Reversing HIV-1 latency promotes killing of infected cells and is essential for cure strategies; however, no single latency reversing agent (LRA) or LRA combination have been shown to reduce HIV-1 latent reservoir size in persons living wi…
View article: Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods
Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods Open
Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the persistence of a latent viral reservoir in resting CD4 + T cells. This reservoir is a major barrier to cure. Sequencing studies have reveale…
View article: Comprehensive Analysis of the Molecular Mechanism for Gastric Cancer Based on Competitive Endogenous RNA Network
Comprehensive Analysis of the Molecular Mechanism for Gastric Cancer Based on Competitive Endogenous RNA Network Open
Objective: To explore the regulatory mechanism of competitive endogenous RNAs (ceRNA) in gastric cancer (GC) and to predict the prognosis of GC. Materials and Methods: Expression profiles of long noncoding RNAs (lncRNAs), microRNAs (miRNAs…
View article: Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy
Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy Open
Significance In persons living with HIV-1 who start antiretroviral therapy, virus in the blood decreases rapidly to below the detection limit. The decrease occurs in two phases: a rapid initial decrease in the first weeks, followed by a se…
View article: Effects of Reducing the South and Reinforcing the North Method on Inflammatory Injury Induced by Hyperlipidemia
Effects of Reducing the South and Reinforcing the North Method on Inflammatory Injury Induced by Hyperlipidemia Open
Inflammation is the pathophysiological basis of hyperlipidemia-related disease (HRD). Reducing the south and reinforcing the north method (RSRN) has a positive effect on HRD. However, the pharmacological mechanisms of RSRN are still unclea…
View article: Delayed Rise of Oral Fluid Antibodies, Elevated BMI, and Absence of Early Fever Correlate With Longer Time to SARS-CoV-2 RNA Clearance in a Longitudinally Sampled Cohort of COVID-19 Outpatients
Delayed Rise of Oral Fluid Antibodies, Elevated BMI, and Absence of Early Fever Correlate With Longer Time to SARS-CoV-2 RNA Clearance in a Longitudinally Sampled Cohort of COVID-19 Outpatients Open
Background Sustained molecular detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the upper respiratory tract (URT) in mild to moderate coronavirus disease 2019 (COVID-19) is common. We sought to identify host…
View article: Delayed rise of oral fluid antibodies, elevated BMI, and absence of early fever correlate with longer time to SARS-CoV-2 RNA clearance in an longitudinally sampled cohort of COVID-19 outpatients
Delayed rise of oral fluid antibodies, elevated BMI, and absence of early fever correlate with longer time to SARS-CoV-2 RNA clearance in an longitudinally sampled cohort of COVID-19 outpatients Open
Background Sustained molecular detection of SARS-CoV-2 RNA in the upper respiratory tract (URT) in mild to moderate COVID-19 is common. We sought to identify host and immune determinants of prolonged SARS-CoV-2 RNA detection. Methods Ninet…
View article: The Clinical Course of COVID-19 in the Outpatient Setting: A Prospective Cohort Study
The Clinical Course of COVID-19 in the Outpatient Setting: A Prospective Cohort Study Open
Background Outpatient coronavirus disease 2019 (COVID-19) has been insufficiently characterized. To determine the progression of disease and determinants of hospitalization, we conducted a prospective cohort study. Methods Outpatient adult…
View article: Self-Collected Oral Fluid Saliva Is Insensitive Compared With Nasal-Oropharyngeal Swabs in the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Outpatients
Self-Collected Oral Fluid Saliva Is Insensitive Compared With Nasal-Oropharyngeal Swabs in the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Outpatients Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic control will require widespread access to accurate diagnostics. Salivary sampling circumvents swab supply chain bottlenecks, is amenable to self-collection, a…
View article: HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo
HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo Open
Significance The latent reservoir for HIV-1 is a major barrier to curing the infection. Current cure strategies are focused on eliminating the reservoir through a two-step “shock and kill” approach involving the use of small-molecule laten…
View article: Deletion of the stress‐response protein REDD1 promotes ceramide‐induced retinal cell death and JNK activation
Deletion of the stress‐response protein REDD1 promotes ceramide‐induced retinal cell death and JNK activation Open
The role of dyslipidemia in the development of retinal dysfunction remains poorly understood. Using an animal model of diet‐induced obesity/pre‐type 2 diabetes, we investigated molecular defects in the retina arising from consumption of a …
View article: CCDC 1856056: Experimental Crystal Structure Determination
CCDC 1856056: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef
A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef Open
View article: SERINC5: Its Sensitivity to Nef and Restriction of HIV-1
SERINC5: Its Sensitivity to Nef and Restriction of HIV-1 Open
The accessory protein Nef of human immunodeficiency virus type 1 (HIV-1) has long been known to enhance the infectivity of HIV-1 progeny virions. The multipass transmembrane proteins serine incorporator 3 (SERINC3) and SERINC5 were recentl…
View article: Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes
Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes Open
Diabetes-induced visual dysfunction is associated with significant neuroretinal cell death. The current study was designed to investigate the role of the Protein Regulated in Development and DNA Damage Response 1 (REDD1) in diabetes-induce…