Shuyang Zhang
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View article: Proteomic and metabolomic profiling reveal alterations in freezing-thawing and fresh drake sperm
Proteomic and metabolomic profiling reveal alterations in freezing-thawing and fresh drake sperm Open
View article: Assessment of Suitable Habitats and Quality of <i>Siraitia grosvenorii</i> in China
Assessment of Suitable Habitats and Quality of <i>Siraitia grosvenorii</i> in China Open
Climate change impacts the habitats of medicinal plants and potentially affects the quality of herbal medicines. Siraitia grosvenorii , a crucial medicinal and edible traditional Chinese material endemic to China, requires more research on…
View article: Capability wellbeing of parents caring for children with rare diseases: a national cross-sectional study
Capability wellbeing of parents caring for children with rare diseases: a national cross-sectional study Open
Background Rare diseases impose significant burden on families, particularly parents, of affected children, involving intensive caregiving, financial hardship, and social isolation. However, there is a scarcity of research exploring the br…
View article: WEAVE: Unleashing and Benchmarking the In-context Interleaved Comprehension and Generation
WEAVE: Unleashing and Benchmarking the In-context Interleaved Comprehension and Generation Open
Recent advances in unified multimodal models (UMMs) have enabled impressive progress in visual comprehension and generation. However, existing datasets and benchmarks focus primarily on single-turn interactions, failing to capture the mult…
View article: A national biobank framework for rare diseases: Standardized infrastructure and cross-institutional collaboration accelerating translational innovation in China
A national biobank framework for rare diseases: Standardized infrastructure and cross-institutional collaboration accelerating translational innovation in China Open
View article: Health-related Quality of Life among Children Living with Rare Diseases in China: a Nationwide Study
Health-related Quality of Life among Children Living with Rare Diseases in China: a Nationwide Study Open
A large proportion of rare diseases (RDs) manifest in childhood, posing substantial physical and psychosocial burden on pediatric populations. This study aims to evaluate the health-related quality of life (HRQoL) and associated factors am…
View article: Differentiation of light chain cardiac amyloidosis and hypertrophic cardiomyopathy by ensemble machine learning-based radiomic analysis of cardiac magnetic resonance
Differentiation of light chain cardiac amyloidosis and hypertrophic cardiomyopathy by ensemble machine learning-based radiomic analysis of cardiac magnetic resonance Open
Background We aim to assess the diagnosis performance of an ensemble machine learning (ML) based radiomic analysis of multiparametric cardiac magnetic resonance (CMR) to differentiate light chain cardiac amyloidosis (AL-CA) and hypertrophi…
View article: Digital health technology use in clinical trials of rare diseases: a systematic review
Digital health technology use in clinical trials of rare diseases: a systematic review Open
View article: 5-aminolevulinic acid improves drake post-thaw sperm quality via enhancing mitochondrial function
5-aminolevulinic acid improves drake post-thaw sperm quality via enhancing mitochondrial function Open
View article: Sequencing of Polyclonal Antibodies by Integrating Intact Mass, Middle–Down, and De Novo Bottom–Up Mass Spectrometry
Sequencing of Polyclonal Antibodies by Integrating Intact Mass, Middle–Down, and De Novo Bottom–Up Mass Spectrometry Open
View article: Multiple protein-protein interactions drive the assembly and budding of the Chikungunya virion
Multiple protein-protein interactions drive the assembly and budding of the Chikungunya virion Open
The assembly of enveloped viruses is a highly orchestrated process that depends on the coupling of multiple protein–protein interactions within a membrane environment. To gain mechanistic insight into this process, we use Chikungunya virus…
View article: SCAP/SREBP2-Mediated Cholesterol Biosynthetic Pathway Suppresses Particulate Matter-Induced Macrophage Activation and Airway Inflammation
SCAP/SREBP2-Mediated Cholesterol Biosynthetic Pathway Suppresses Particulate Matter-Induced Macrophage Activation and Airway Inflammation Open
The SCAP/SREBP2-mediated cholesterol synthesis pathway inhibits macrophage activation and airway inflammation induced by PM through the production of cholesterol.
View article: Virtual Reality Interventions for Spinal Cord Injury-Related Neuropathic Pain: A Comprehensive Scoping Review of Multidimensional Outcomes
Virtual Reality Interventions for Spinal Cord Injury-Related Neuropathic Pain: A Comprehensive Scoping Review of Multidimensional Outcomes Open
Current evidence suggests VR technology may serve as an effective adjunct to, rather than replacement for, conventional treatment. Despite limited evidence, VR demonstrates promising analgesic efficacy and emotional enhancement potential i…
View article: Experimental mapping of bacterial fitness landscapes reveals eco-evolutionary fingerprints
Experimental mapping of bacterial fitness landscapes reveals eco-evolutionary fingerprints Open
Understanding microbial dynamics in natural environments remains a significant challenge. As an alternative approach, studying model bacterial strains under well-defined laboratory conditions can reveal ecological niche patterns and evolut…
View article: Deep insights and clinical benefits from the comprehensive cohort of fetal skeletal dysplasia in China
Deep insights and clinical benefits from the comprehensive cohort of fetal skeletal dysplasia in China Open
Fetal skeletal dysplasia (FSD) encompasses diverse clinical features and complicates prenatal diagnosis and perinatal care. In this retrospective study, we integrate prenatal deep phenotyping with exome or genome sequencing (ES/GS) to eluc…
View article: Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis
Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis Open
Background and aims Covert MRI markers of cerebral small vessel disease (CSVD) can coexist with large artery atherosclerosis. We aimed to explore whether the spatial distributions of these markers were diverse in people with or without int…
View article: Development and Internal Validation of a Clinical Imaging–Based Stroke Prediction Model in a Community Cohort
Development and Internal Validation of a Clinical Imaging–Based Stroke Prediction Model in a Community Cohort Open
Background Existing stroke prediction models tend to overestimate contemporary stroke risk and inadequately incorporate neuroimaging parameters. This study aimed to develop a novel and accurate stroke prediction model for a community‐based…
View article: Associations between cardiometabolic indices and heart disease among elderly and middle-aged Chinese individuals: a retrospective longitudinal study
Associations between cardiometabolic indices and heart disease among elderly and middle-aged Chinese individuals: a retrospective longitudinal study Open
The cardiometabolic index (CMI) is a marker for evaluating visceral adipose distribution and lipid metabolism. This index is useful for detecting metabolic diseases as well as some cardiovascular diseases. The link between the CMI and hear…
View article: Effects of Mavacamten on Cardiac Magnetic Resonance Features in Chinese Patients With Obstructive Hypertrophic Cardiomyopathy
Effects of Mavacamten on Cardiac Magnetic Resonance Features in Chinese Patients With Obstructive Hypertrophic Cardiomyopathy Open
At 30 weeks, improvements were observed in measures of cardiac structure and function, with reductions in indicators of myocardial fibrosis, in the mavacamten vs the placebo group. (A Study to Evaluate the Efficacy and Safety of Mavacamten…
View article: Case Report: Effect of transcutaneous auricular vagus nerve stimulation on acute pain after external fixation for bilateral open tibiofibular fractures
Case Report: Effect of transcutaneous auricular vagus nerve stimulation on acute pain after external fixation for bilateral open tibiofibular fractures Open
A 50-year-old female patient sustained bilateral tibiofibular fractures due to a traffic accident and underwent open external fixation surgery on both lower limbs. Postoperatively, she reported severe pain (VAS ≥ 8). The patient had no sig…
View article: Automated ejection fraction and risk stratification in cardiomyopathy patients with diverse LV geometry using 2D echocardiography
Automated ejection fraction and risk stratification in cardiomyopathy patients with diverse LV geometry using 2D echocardiography Open
View article: Impact of early and delayed azvudine administration on COVID-19 mortality: a retrospective study
Impact of early and delayed azvudine administration on COVID-19 mortality: a retrospective study Open
View article: Assessment of suitable habitats and quality of Siraitia grosvenorii in China
Assessment of suitable habitats and quality of Siraitia grosvenorii in China Open
View article: Microalgal-enhanced cerium oxide nanotherapeutics for alleviating inflammatory bowel disease via scavenging reactive oxygen species and modulating gut microbiota in colitis
Microalgal-enhanced cerium oxide nanotherapeutics for alleviating inflammatory bowel disease via scavenging reactive oxygen species and modulating gut microbiota in colitis Open
View article: Association of cross-life-cycle body size and genetic risk with cardio-renal-metabolic conditions in adulthood: evidence from a prospective cohort study
Association of cross-life-cycle body size and genetic risk with cardio-renal-metabolic conditions in adulthood: evidence from a prospective cohort study Open
Background: The aim of this study was to investigate the longitudinal associations between the body size trajectory and the cardio-renal-metabolic (CRM) conditions in adulthood, and evaluate the joint association between body size trajecto…
View article: Long-term Metformin Alters Gut Microbiota and Serum Metabolome in Coronary Artery Disease Patients After Percutaneous Coronary Intervention to Improve 5-year Prognoses: A Multi-omics Analysis
Long-term Metformin Alters Gut Microbiota and Serum Metabolome in Coronary Artery Disease Patients After Percutaneous Coronary Intervention to Improve 5-year Prognoses: A Multi-omics Analysis Open
Background: About 20% of patients with coronary artery disease (CAD) experience adverse events within five years of undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction. In these patients, the impact of metfo…
View article: Unraveling gut microbiome alterations and metabolic signatures in hereditary transthyretin amyloidosis
Unraveling gut microbiome alterations and metabolic signatures in hereditary transthyretin amyloidosis Open
Hereditary transthyretin amyloidosis (hATTR) is a rare, often fatal disease characterized by the abnormal aggregation of atypical transthyretin fibrils. Given the variability in the penetrance and clinical manifestations of hATTR, the role…
View article: Effect of Mavacamten on Echocardiographic Features in Chinese Patients with Obstructive Hypertrophic Cardiomyopathy: Results from the EXPLORER-CN Study
Effect of Mavacamten on Echocardiographic Features in Chinese Patients with Obstructive Hypertrophic Cardiomyopathy: Results from the EXPLORER-CN Study Open
ClinicalTrials.gov identifier: NCT05174416.
View article: Structural and biochemical mechanism of short-chain enoyl-CoA hydratase (ECHS1) substrate recognition
Structural and biochemical mechanism of short-chain enoyl-CoA hydratase (ECHS1) substrate recognition Open
Deficiency of short-chain enoyl-CoA hydratase (ECHS1), a crucial enzyme in fatty acid metabolism through the mitochondrial β-oxidation pathway, has been strongly linked to various diseases, especially cardiomyopathy. However, the structura…
View article: Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4
Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4 Open
The G protein–coupled cysteinyl leukotriene receptor CysLT2R plays intricate roles in the physiology and pathogenesis of inflammation-related processes. It has garnered increasing attention as a potential therapeutic target for atopic asth…