Michael Zhang
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View article: Growth Prediction of Type B Aortic Dissections Using Wall-Stress-Driven Finite Element Simulation Based on the Unified-Fiber-Distribution (UFD) Model
Growth Prediction of Type B Aortic Dissections Using Wall-Stress-Driven Finite Element Simulation Based on the Unified-Fiber-Distribution (UFD) Model Open
Type B aortic dissection (TBAD) is a serious, potentially life-threatening condition which occurs when a tear develops in the inner lining (intimal layer) of the descending aorta, causing the layers of the aortic wall to separate (dissect)…
View article: WiseMind: Recontextualizing AI with a Knowledge-Guided, Theory-Informed Multi-Agent Framework for Instrumental and Humanistic Benefits
WiseMind: Recontextualizing AI with a Knowledge-Guided, Theory-Informed Multi-Agent Framework for Instrumental and Humanistic Benefits Open
Purpose: Translating state-of-the-art NLP into real-world psychiatric diagnosis is challenging due to a lack of domain-specific contextualization across knowledge, processes, and evaluation. We introduce WiseMind, an interdisciplinary fram…
View article: EXTH-52. Spatially Resolved Antigenic Landscapes In Low-grade Glioma Reveal Targets For Personalized Immunotherapy
EXTH-52. Spatially Resolved Antigenic Landscapes In Low-grade Glioma Reveal Targets For Personalized Immunotherapy Open
BACKGROUND Low-grade gliomas (LGGs) exhibit low overall mutational burden and an immunosuppressive microenvironment, contributing to immunotherapy resistance. Intratumoral heterogeneity (ITH) further complicates the targeting of tumor-spec…
View article: Changes in Aortic Centerline Length and Curvature Predict Aortic Diameter Growth in Chronic Type B Aortic Dissection
Changes in Aortic Centerline Length and Curvature Predict Aortic Diameter Growth in Chronic Type B Aortic Dissection Open
Objective Aortic diameter is the primary metric used to trigger surgical intervention in chronic Type B aortic dissection (TBAD) This study investigates the correlation between diameter growth and changes in aortic centerline length, curva…
View article: Genome-wide meta-analyses of cross substance use disorders in diverse populations
Genome-wide meta-analyses of cross substance use disorders in diverse populations Open
Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studie…
View article: MMORE: Massive Multimodal Open RAG & Extraction
MMORE: Massive Multimodal Open RAG & Extraction Open
We introduce MMORE, an open-source pipeline for Massive Multimodal Open RetrievalAugmented Generation and Extraction, designed to ingest, transform, and retrieve knowledge from heterogeneous document formats at scale. MMORE supports more t…
View article: The JWST Rocky Worlds DDT Program reveals GJ 3929b to likely be a bare rock
The JWST Rocky Worlds DDT Program reveals GJ 3929b to likely be a bare rock Open
We report first results from the JWST Rocky Worlds Director's Discretionary Time program. Two secondary eclipses of the terrestrial exoplanet GJ 3929b were recently observed using MIRI photometric imaging at 15 um. We present a reduction o…
View article: Prolonged dengue viremia with predominantly ocular manifestations in a lung transplant recipient
Prolonged dengue viremia with predominantly ocular manifestations in a lung transplant recipient Open
View article: A Needle in a Haystack: Leveraging Machine Learning for Drug-Mechanism of Action Identification across Existing Therapeutics, with Specific Applications for Drug Repurposing for Rare Diseases
A Needle in a Haystack: Leveraging Machine Learning for Drug-Mechanism of Action Identification across Existing Therapeutics, with Specific Applications for Drug Repurposing for Rare Diseases Open
Rare diseases are a prevalent problem within the healthcare sector, primarily due to the multitude of conditions and the limited profiling available for each. Consequently, developing novel therapeutics for rare diseases through traditiona…
View article: Association of peripheral nerve blocks with increased postoperative pain and opioid use in orthopaedic surgery: a single-centre retrospective cohort study
Association of peripheral nerve blocks with increased postoperative pain and opioid use in orthopaedic surgery: a single-centre retrospective cohort study Open
View article: Greater Central Adiposity Is Associated With Poorer Left Atrial Function: The Atherosclerosis Risk in Communities (ARIC) Study
Greater Central Adiposity Is Associated With Poorer Left Atrial Function: The Atherosclerosis Risk in Communities (ARIC) Study Open
View article: Kaleidoscope: In-language Exams for Massively Multilingual Vision Evaluation
Kaleidoscope: In-language Exams for Massively Multilingual Vision Evaluation Open
The evaluation of vision-language models (VLMs) has mainly relied on English-language benchmarks, leaving significant gaps in both multilingual and multicultural coverage. While multilingual benchmarks have expanded, both in size and langu…
View article: Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023
Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023 Open
Background Limited research has explored the effect of high-density lipoprotein cholesterol (HDL-C) on lung cancer’s seven autoantibodies (7-AABs). This study investigated the association between serum HDL-C and 7-AABs among 5,574 Chinese …
View article: Sailor2: Sailing in South-East Asia with Inclusive Multilingual LLMs
Sailor2: Sailing in South-East Asia with Inclusive Multilingual LLMs Open
Sailor2 is a family of cutting-edge multilingual language models for South-East Asian (SEA) languages, available in 1B, 8B, and 20B sizes to suit diverse applications. Building on Qwen2.5, Sailor2 undergoes continuous pre-training on 500B …
View article: Jaws Cbct-Based Radiomics for Identification of Carotid Artery Atherosclerosis and Plaque Characteristics
Jaws Cbct-Based Radiomics for Identification of Carotid Artery Atherosclerosis and Plaque Characteristics Open
View article: Electroencephalogram-Guided General Anesthesia in a Pediatric Patient With Alexander’s Disease: A Case Report
Electroencephalogram-Guided General Anesthesia in a Pediatric Patient With Alexander’s Disease: A Case Report Open
In this case, the electroencephalogram (EEG) was used to guide anesthesia care for a pediatric patient with Alexander’s Disease undergoing serial intrathecal injections. Previous procedures using a standard maintenance propofol dose of up …
View article: Alcohol Use Disorder Polygenic Score Compared With Family History and <i>ADH1B</i>
Alcohol Use Disorder Polygenic Score Compared With Family History and <i>ADH1B</i> Open
Importance Identification of individuals at high risk of alcohol use disorder (AUD) and subsequent application of prevention and intervention programs has been reported to decrease the incidence of AUD. The polygenic score (PGS), which mea…
View article: Using polygenic risk scores and <i>APOE</i> e4 to evaluate the risk for Alzheimer’s disease in European ancestry populations
Using polygenic risk scores and <i>APOE</i> e4 to evaluate the risk for Alzheimer’s disease in European ancestry populations Open
Background APOE e4 has been used to evaluate the risk for Alzheimer’s diseases (AD) but there exist other AD risk genes, and their effects can be collectively measured by polygenic risk scores (PRS). In this study, we sought to use both PR…
View article: 155 Sub-clonal antigenic heterogeneity mediates immune evasion in low-grade gliomas
155 Sub-clonal antigenic heterogeneity mediates immune evasion in low-grade gliomas Open
View article: An international study presenting a federated learning AI platform for pediatric brain tumors
An international study presenting a federated learning AI platform for pediatric brain tumors Open
While multiple factors impact disease, artificial intelligence (AI) studies in medicine often use small, non-diverse patient cohorts due to data sharing and privacy issues. Federated learning (FL) has emerged as a solution, enabling traini…
View article: Stereotactic radiosurgery for brain metastases from human epidermal receptor 2 positive breast Cancer: an international, multi-center study
Stereotactic radiosurgery for brain metastases from human epidermal receptor 2 positive breast Cancer: an international, multi-center study Open
Purpose To report patient outcomes and local tumor control rates in a cohort of patients with biopsy-proven HER-2 positive breast cancer treated with stereotactic radiosurgery (SRS) for brain metastases (BM). Methods This international, re…
View article: Nonlinear association between the triglyceride-glucose index and diabetes mellitus in overweight and obese individuals: a cross-sectional retrospective analysis
Nonlinear association between the triglyceride-glucose index and diabetes mellitus in overweight and obese individuals: a cross-sectional retrospective analysis Open
Among overweight or obese individuals, a higher TyG index is associated with an elevated risk of diabetes, especially when TyG is > 4.46. Furthermore, factors such as sex, age, and BMI significantly influence the risk of diabetes in overwe…
View article: Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations
Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations Open
View article: Nonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data
Nonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data Open
Background The atherogenic index of plasma (AIP) is closely associated with the onset of diabetes, with obesity being a significant risk factor for type 2 diabetes mellitus (T2DM). However, the association between the AIP and T2DM in overw…
View article: Association between liver fat level and risk of hypertension: evidence from a Chinese health examination dataset
Association between liver fat level and risk of hypertension: evidence from a Chinese health examination dataset Open
Background: Hypertension development is predominantly influenced by inflammation, excessive fat deposition, and metabolic irregularities. Among these factors, liver fat accumulation is a critical metabolic disorder. However, the quantifica…
View article: Stereotactic Radiosurgery for Brain Metastases from Human Epidermal Receptor 2 Positive Breast Cancer: An International, Multi-center Study
Stereotactic Radiosurgery for Brain Metastases from Human Epidermal Receptor 2 Positive Breast Cancer: An International, Multi-center Study Open
Purpose To report patient outcomes and local tumor control rates in a cohort of patients with biopsy-proven HER-2 positive breast cancer treated with stereotactic radiosurgery (SRS) for brain metastases (BM). Methods This international, re…
View article: An Inverted U-shaped Relationship between Neutrophil-to-Lymphocyte Ratio and Hypertension in Overweight and Obese Populations: Evidence from a Large-scale Health Screening Data
An Inverted U-shaped Relationship between Neutrophil-to-Lymphocyte Ratio and Hypertension in Overweight and Obese Populations: Evidence from a Large-scale Health Screening Data Open
Background The Neutrophil-to-Lymphocyte Ratio (NLR) is associated with the development and progression of hypertension, and obesity is a significant risk factor for hypertension. However, the relationship between NLR and overweight and obe…
View article: Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma
Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma Open
Oral squamous cell carcinoma (OSCC) presents significant treatment challenges due to its poor survival and intense pain at the primary cancer site. Cancer pain is debilitating, contributes to diminished quality of life, and causes opioid t…
View article: Design and Usability of an Open-Source, Low-Cost Flexible Laryngoscope for Resource-Limited Settings
Design and Usability of an Open-Source, Low-Cost Flexible Laryngoscope for Resource-Limited Settings Open
Importance Endoscopes are paramount to the practice of otolaryngology. To provide physicians in low-middle–income countries with adequate tools to treat otolaryngologic problems, it is necessary to create a low-cost sustainable option. Obj…
View article: Association between high-density lipoprotein cholesterol and lumbar bone mineral density in Chinese: a large cross-sectional study
Association between high-density lipoprotein cholesterol and lumbar bone mineral density in Chinese: a large cross-sectional study Open