Shicui Zhang
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View article: Donkey Milk Improves Dextran Sulfate Sodium‐Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4/MyD88/NF‐κB Signaling Pathway, and Modulating Gut Microbiota
Donkey Milk Improves Dextran Sulfate Sodium‐Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4/MyD88/NF‐κB Signaling Pathway, and Modulating Gut Microbiota Open
Donkey milk (DM) demonstrates promising bioactive properties, including anti‐inflammatory and microbiota‐modulating effects with therapeutic potential for ulcerative colitis (UC)—though mechanistic research remains limited. To bridge this …
View article: Effects of Sea Buckthorn Fruits on Production Performance and Egg Quality of Chicken Gallus gallus domesticus ‘Wuhei’
Effects of Sea Buckthorn Fruits on Production Performance and Egg Quality of Chicken Gallus gallus domesticus ‘Wuhei’ Open
This study was conducted to examine the effects of sea buckthorn fruits (SBF) on the production performance and egg quality of chickens during the initial stage of the laying period. A total of 160 chickens were randomly divided into four …
View article: Antifungal peptides from living organisms
Antifungal peptides from living organisms Open
In the post-COVID-19 era, people are increasingly concerned about microbial infections, including fungal infections that have risen in recent years. However, the currently available antifungal agents are rather limited. Worse still, the wi…
View article: Anticancer activities of natural antimicrobial peptides from animals
Anticancer activities of natural antimicrobial peptides from animals Open
Cancer is the most common cause of human death worldwide, posing a serious threat to human health and having a negative impact on the economy. In the past few decades, significant progress has been made in anticancer therapies, but traditi…
View article: Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources
Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources Open
Aging is a natural and inescapable phenomenon characterized by a progressive deterioration of physiological functions, leading to increased vulnerability to chronic diseases and death. With economic and medical development, the elderly pop…
View article: Cd248a and Cd248b in zebrafish participate in innate immune responses
Cd248a and Cd248b in zebrafish participate in innate immune responses Open
CD248, also known as endosialin or tumor endothelial marker 1, is a type I single transmembrane glycoprotein. CD248 has been demonstrated to be upregulated in cancers, tumors and many fibrotic diseases in human and mice, such as liver dama…
View article: Fungicidal Activity of AP10W, a Short Peptide Derived from AP-2 Complex Subunit mu-A, In Vitro and In Vivo
Fungicidal Activity of AP10W, a Short Peptide Derived from AP-2 Complex Subunit mu-A, In Vitro and In Vivo Open
With the increase in the incidence of fungal infections, and the restrictions of existing antifungal drugs, the development of novel antifungal agents is urgent. Here we prove that AP10W, a short peptide derived from AP-2 complex subunit m…
View article: Bmp8a Is a Novel Player in Regulation of Antiviral Immunity
Bmp8a Is a Novel Player in Regulation of Antiviral Immunity Open
Bone morphogenetic protein (BMP) is a kind of classical multi-functional growth factor that plays a vital role in the formation and maintenance of bone, cartilage, muscle, blood vessels, and the regulation of energy balance. Whether BMP pl…
View article: New Tricks for an old molecule: Preserved antibacterial activity of ribosomal protein S15 during evolution
New Tricks for an old molecule: Preserved antibacterial activity of ribosomal protein S15 during evolution Open
Previous studies show that some ribosomal proteins possess antimicrobial peptide (AMP) activity. However, information as such remains rather fragmentary and limited. Here we demonstrated for the first time that amphioxus RPS15, BjRPS15, wa…
View article: Identification of ATP synthase α subunit as a new maternal factor capable of protecting zebrafish embryos from bacterial infection
Identification of ATP synthase α subunit as a new maternal factor capable of protecting zebrafish embryos from bacterial infection Open
Previous studies have shown that ATP synthase α subunit (ATP5A1) plays multiple roles, but our understanding of its biologic functions remains poor and incomprehensive. Here, we clearly demonstrated that zebrafish ATP5A1 was a newly charac…
View article: BMP signaling is required for amphioxus tail regeneration
BMP signaling is required for amphioxus tail regeneration Open
Amphioxus, a cephalochordate, is an ideal animal in which to address questions about the evolution of regenerative ability and the mechanisms behind the invertebrate to vertebrate transition in chordates. However, the cellular and molecula…
View article: Functional Characterization of Thyrostimulin in Amphioxus Suggests an Ancestral Origin of the TH Signaling Pathway
Functional Characterization of Thyrostimulin in Amphioxus Suggests an Ancestral Origin of the TH Signaling Pathway Open
Thyrostimulin, consisting of GpA2 and GpB5 subunits, has been identified in amphioxus, but to date, little is known about the roles of GPA2/GPB5‒type hormone in this evolutionarily important animal. We showed here that amphioxus GpA2, GpB5…
View article: Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish <i>Nothobranchius guentheri</i>
Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish <i>Nothobranchius guentheri</i> Open
One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Previous studies have shown that salidroside can protect D-galactose-induced mouse model against aging and a formulation of Rhodiola r…
View article: Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain
Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain Open
Genes generated by whole genome duplications (WGD) can be co-opted by changing their regulation process or altering their coding proteins, which has been shown contributable to the emergence of vertebrate morphological novelties such as ve…
View article: Functional characterization of thyrostimulin in amphioxus suggests an ancestral origin of the TH signaling pathway (Supplemental Materials and Tables).docx
Functional characterization of thyrostimulin in amphioxus suggests an ancestral origin of the TH signaling pathway (Supplemental Materials and Tables).docx Open
Supplemental Materials and Tables
View article: Demonstration of a Functional Kisspeptin/Kisspeptin Receptor System in Amphioxus With Implications for Origin of Neuroendocrine Regulation
Demonstration of a Functional Kisspeptin/Kisspeptin Receptor System in Amphioxus With Implications for Origin of Neuroendocrine Regulation Open
Amphioxus belongs to the Cephalochordata, which is the most basal subphylum of the chordates. Despite many studies on the endocrine system of amphioxus, key information about its regulation remains ambiguous. Here we clearly demonstrate th…
View article: Activities of Amphioxus GH-Like Protein in Osmoregulation: Insight into Origin of Vertebrate GH Family
Activities of Amphioxus GH-Like Protein in Osmoregulation: Insight into Origin of Vertebrate GH Family Open
GH is known to play an important role in both growth promotion and osmoregulation in vertebrates. We have shown that amphioxus possesses a single GH-like hormone (GHl) gene encoding a functional protein capable of promoting growth. However…
View article: Identification of Ly2 members as antimicrobial peptides from zebrafish <i>Danio rerio</i>
Identification of Ly2 members as antimicrobial peptides from zebrafish <i>Danio rerio</i> Open
The emergence of multidrug-resistant (MDR) microbes caused by overuse of antibiotics leads to urgent demands for novel antibiotics exploration. Our recent data showed that Ly2.1–3 (a novel lymphocyte antigen 6 (Ly6) gene cluster) were prot…
View article: Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections
Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections Open
Zinc finger ZRANB2 proteins are widespread in animals, but their functions and mechanisms remain poorly defined. Here we clearly demonstrate that ZRANB2 is a newly identified LPS-binding protein present abundantly in the eggs/embryos of ze…