Yingzhe Zhang
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View article: From Normal Variation in Sleep to Clinical Sleep Disorders: Genetic Insights from Over One Million Individuals
From Normal Variation in Sleep to Clinical Sleep Disorders: Genetic Insights from Over One Million Individuals Open
Sleep disorders affect over 30% of the U.S population and are linked to increased disease risk and mortality. However, the genetic architecture of sleep disorders and the overlap of sleep disorders with habitual sleep quality, quantity, an…
View article: The genetics of cannabis lifetime use
The genetics of cannabis lifetime use Open
Cannabis is one of the most commonly used drugs in the world, and use is trending alarmingly higher. We aimed to examine the genetic basis of cannabis lifetime use (CanLU) and its genetic relationships with a variety of psychiatric- and ph…
View article: Functional consequences of genetic risk for neuropsychiatric conditions at chr22q
Functional consequences of genetic risk for neuropsychiatric conditions at chr22q Open
Understanding how common and rare genetic variation raises risk for neuropsychiatric disease remains a major challenge. We identify the long arm of chromosome 22 (chr22q) as a region where common polygenic risk for schizophrenia, autism, A…
View article: Towards Scalable Biomarker Discovery in Posttraumatic Stress Disorder: Triangulating Genomic and Phenotypic Evidence from a Health System Biobank
Towards Scalable Biomarker Discovery in Posttraumatic Stress Disorder: Triangulating Genomic and Phenotypic Evidence from a Health System Biobank Open
Importance Biomarkers can potentially improve the diagnosis, monitoring, and treatment of posttraumatic stress disorder (PTSD). However, PTSD biomarkers that are scalable and easily integrated into real-world clinical settings have not bee…
View article: Evaluating hypothetical prevention strategies for internalizing symptoms in the general population and at-risk children.
Evaluating hypothetical prevention strategies for internalizing symptoms in the general population and at-risk children. Open
With a causally informed strategy, we demonstrated the potential effects of numerous hypothetical interventions on modifiable factors for depression risk reduction, across multiple preventive settings. (PsycInfo Database Record (c) 2025 AP…
View article: Tumor-educated cells in tumor microenvironment: Key drivers of immunotherapy resistance
Tumor-educated cells in tumor microenvironment: Key drivers of immunotherapy resistance Open
In the past decade, immunotherapies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death 1 (PD-1), and PD-1 ligand (PD-L1) have been approved for solid tumors. However, some patients demonstrate suboptimal clinical ou…
View article: The association of objectively and subjectively measured<i>modifiable</i>lifestyle factors with internalizing problems: The role of genetic confounding and shared method variance<i>bias</i>
The association of objectively and subjectively measured<i>modifiable</i>lifestyle factors with internalizing problems: The role of genetic confounding and shared method variance<i>bias</i> Open
Background Sleep duration and physical activity have been associated with internalizing problems, such as depression, in observational studies. However, genetic confounding and measurement error may introduce bias. We assessed genetic conf…
View article: Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors
Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors Open
Deep phenotyping is an important next step to improve understanding of the genetic etiology of AUBs, in addition to increasing sample size. Further effort is required to uncover the genetic heterogeneity underlying AUBs using methods that …
View article: Enhancing Suicide Risk Prediction With Polygenic Scores in Psychiatric Emergency Settings: Prospective Study
Enhancing Suicide Risk Prediction With Polygenic Scores in Psychiatric Emergency Settings: Prospective Study Open
Background Despite growing interest in the clinical translation of polygenic risk scores (PRSs), it remains uncertain to what extent genomic information can enhance the prediction of psychiatric outcomes beyond the data collected during cl…
View article: Sex hormones and Sjögren’s Disease: A Mendelian randomization study
Sex hormones and Sjögren’s Disease: A Mendelian randomization study Open
Background Postmenopausal women have a higher risk of developing Sjögren’s Disease (SjD) than men, indicating the involvement of sex hormones. The objective of this study was to investigate the causal relationship between sex hormones and …
View article: Enhancing Suicide Risk Prediction With Polygenic Scores in Psychiatric Emergency Settings: Prospective Study (Preprint)
Enhancing Suicide Risk Prediction With Polygenic Scores in Psychiatric Emergency Settings: Prospective Study (Preprint) Open
BACKGROUND Despite growing interest in the clinical translation of polygenic risk scores (PRSs), it remains uncertain to what extent genomic information can enhance the prediction of psychiatric outcomes beyond the data collected during c…
View article: Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors
Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors Open
Background Increasingly large samples in genome-wide association studies (GWAS) for alcohol use behaviors (AUBs) have led to an influx of implicated genes, yet the clinical and functional understanding of these associations remains low. Th…
View article: The pleiotropic architecture of human impulsivity across biological scales
The pleiotropic architecture of human impulsivity across biological scales Open
Impulsivity is a complex psychological construct that represents a core feature of many psychiatric and neurological conditions. Here, we used multivariate methods to formally model the genetic architecture of impulsivity in humans, advanc…
View article: Shared Genetic Risk in the Association of Screen Time With Psychiatric Problems in Children
Shared Genetic Risk in the Association of Screen Time With Psychiatric Problems in Children Open
Importance Children’s exposure to screen time has been associated with poor mental health outcomes, yet the role of genetic factors remains largely unknown. Objective To assess the extent of genetic confounding in the associations between …
View article: A Programmable CRISPR/Cas9 Toolkit Improves Lycopene Production in Bacillus subtilis
A Programmable CRISPR/Cas9 Toolkit Improves Lycopene Production in Bacillus subtilis Open
We present a toolkit that allows for rapid cloning procedures and one-step subcloning to move from plasmid-based expression to stable chromosome integration and expression in a production strain in less than a week. The utility of the cust…
View article: A Numerical Study on the Flap Side-Edge Noise Reduction Using Passive Blowing Air Concept
A Numerical Study on the Flap Side-Edge Noise Reduction Using Passive Blowing Air Concept Open
The flap side-edge is a vital contributor to airframe noise. In this study, we propose a novel flap side-edge noise reduction method based on the concept of active blowing air. A long slot is opened from the flap’s lower surface to the tip…
View article: Outcomes of Partial Versus Complete Goniotomy With or Without Phacoemulsification for Primary Open Angle Glaucoma: A Multicenter Study
Outcomes of Partial Versus Complete Goniotomy With or Without Phacoemulsification for Primary Open Angle Glaucoma: A Multicenter Study Open
Précis: Goniotomy (GT) 120 degrees with or without phacoemulsification was sufficient to lower the intraocular pressure (IOP) and reduce hyphema for primary open angle glaucoma. Purpose: To compare the surgical outcomes and safety profiles…
View article: Corrigendum: Progress and perspectives of perioperative immunotherapy in non-small cell lung cancer
Corrigendum: Progress and perspectives of perioperative immunotherapy in non-small cell lung cancer Open
[This corrects the article DOI: 10.3389/fonc.2023.1011810.].
View article: The associations of child screen time with psychiatric problems: the role of genetic confounding
The associations of child screen time with psychiatric problems: the role of genetic confounding Open
Importance Children’s exposure to screen time has been associated with poor mental health outcomes, yet the role of genetic factors in this association remains largely unknown. Objective We examined (1) the longitudinal phenotypic associat…
View article: Progress and perspectives of perioperative immunotherapy in non-small cell lung cancer
Progress and perspectives of perioperative immunotherapy in non-small cell lung cancer Open
Lung cancer is one of the leading causes of cancer-related death. Lung cancer mortality has decreased over the past decade, which is partly attributed to improved treatments. Curative surgery for patients with early-stage lung cancer is th…
View article: Study on Microstructure of Fiber Laser Welding of CoCrCuFeNi High Entropy Alloy
Study on Microstructure of Fiber Laser Welding of CoCrCuFeNi High Entropy Alloy Open
A CoCrCuFeNi high-entropy alloy was successfully welded in this study using fiber laser welding. The effects of the welding parameters on the microstructure and mechanical properties were studied. Three zones were formed: the fusion zone, …
View article: Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy
Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy Open
A tertiary lymphoid structure (TLS) is a special component in the immune microenvironment that is mainly composed of tumor-infiltrating lymphocytes (TILs), including T cells, B cells, DC cells, and high endothelial venules (HEVs). For canc…
View article: Differences in cortical morphology and child internalizing or externalizing problems: Accounting for the co‐occurrence
Differences in cortical morphology and child internalizing or externalizing problems: Accounting for the co‐occurrence Open
Background Childhood internalizing and externalizing problems frequently co‐occur. Many studies report neural correlates of either internalizing or externalizing problems, but few account for their co‐occurrence. We aimed to assess specifi…
View article: Safety and Efficacy of Posterior Scleral Application of Mitomycin C-Soaked Sponge in Trabeculectomy
Safety and Efficacy of Posterior Scleral Application of Mitomycin C-Soaked Sponge in Trabeculectomy Open
Background/Objectives: To evaluate the safety and efficacy of posterior scleral application (a modified technique) of antimetabolite mitomycin C (MMC)-soaked sponge in trabeculectomy for patients with glaucoma. Subjects/Methods: A total of…
View article: One-Year Results of a Multicenter Study: Intraocular Pressure–Lowering Effect of Combined Phacoemulsification, Goniosynechialysis, and Goniotomy for Cases of Advanced Primary Angle-Closure Glaucoma With Cataract
One-Year Results of a Multicenter Study: Intraocular Pressure–Lowering Effect of Combined Phacoemulsification, Goniosynechialysis, and Goniotomy for Cases of Advanced Primary Angle-Closure Glaucoma With Cataract Open
The 1-year results of combination of PEI+GSL+GT in treating advanced PACG cases with cataract appear to be safe and effective. Further large-scale multination and multicenter studies are warranted.
View article: Efficacy and safety of trabeculectomy versus peripheral iridectomy plus goniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre, non-inferiority, randomised controlled trial (the TVG study)
Efficacy and safety of trabeculectomy versus peripheral iridectomy plus goniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre, non-inferiority, randomised controlled trial (the TVG study) Open
Introduction Primary angle-closure glaucoma (PACG) is a major subtype of glaucoma that accounts for most bilateral glaucoma-related blindness globally. Filtering surgery is a conventional strategy for PACG, yet it has a long learning curve…