Zhiwei Shen
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View article: Quantitative assessment of lumbar intervertebral disc degeneration and its correlation with clinical symptoms: a study utilizing ultrashort time-of-echo and T2 mapping as biomarkers
Quantitative assessment of lumbar intervertebral disc degeneration and its correlation with clinical symptoms: a study utilizing ultrashort time-of-echo and T2 mapping as biomarkers Open
Background Lumbar cartilage endplate (CEP) structures show low signal intensity on conventional magnetic resonance imaging (MRI), making them hard to observe and quantify. This often results in poor correlation between conventional MRI fin…
View article: Network analysis used to investigate the symptoms of cancer patients during chemotherapy: a scoping review
Network analysis used to investigate the symptoms of cancer patients during chemotherapy: a scoping review Open
Symptom network analysis offers insights into the complex interplay of symptoms during chemotherapy, highlighting fatigue as a central symptom. Future research should focus on longitudinal studies to better understand the dynamic changes i…
View article: Construction and optimization of quantitative analysis models for pigments in broccoli (Brassica oleracea L. var. italica) based on near-infrared spectroscopy technology
Construction and optimization of quantitative analysis models for pigments in broccoli (Brassica oleracea L. var. italica) based on near-infrared spectroscopy technology Open
View article: Exploring the asynchronous changes of articular cartilage and osteochondral junction in knee osteoarthritis based on T2 mapping and ultrashort echo time imaging: a pilot study
Exploring the asynchronous changes of articular cartilage and osteochondral junction in knee osteoarthritis based on T2 mapping and ultrashort echo time imaging: a pilot study Open
The T2 and UTE-T2* values, respectively, provide quantitative and non-invasive measures of the degeneration in the AC and the OCJ during the early stages of KOA. Quantitative MRI biomarkers reveal biochemical alterations in both the AC and…
View article: Fructus Gardenia Extract Improves Cerebral Ischemia-Reperfusion Injury via RIPK1-RIPK3-MLKL Axis
Fructus Gardenia Extract Improves Cerebral Ischemia-Reperfusion Injury via RIPK1-RIPK3-MLKL Axis Open
View article: Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging
Glucose chemical exchange saturation transfer MRI for predicting the histological grade of rectal cancer: a comparative study with amide proton transfer-weighted and diffusion-weighted imaging Open
View article: Quantitative Assessment of Lumbar Intervertebral Disc Degeneration and Its Correlation with Clinical Symptoms: A Study Utilizing Ultrashort Time-of-Echo and T2 Mapping as Biomarkers
Quantitative Assessment of Lumbar Intervertebral Disc Degeneration and Its Correlation with Clinical Symptoms: A Study Utilizing Ultrashort Time-of-Echo and T2 Mapping as Biomarkers Open
Background: Lumbar cartilage endplate (CEP) structures show low signal intensity on conventional magnetic resonance imaging (MRI), making them hard to observe and quantify. This often results in poor correlation between conventional MRI fi…
View article: Amide proton transfer weighted contrast has diagnostic capacity in detecting diabetic foot: an MRI-based case–control study
Amide proton transfer weighted contrast has diagnostic capacity in detecting diabetic foot: an MRI-based case–control study Open
Objective To evaluate the role of foot muscle amide proton transfer weighted (APTw) contrast and tissue rest perfusion in quantifying diabetic foot (DF) infection and its correlation with blood parameters. Materials and methods With approv…
View article: Generalizing Capacity Estimation for Cross-Domain Lithium-Ion Batteries with Deep Multi-Domain Adaptation
Generalizing Capacity Estimation for Cross-Domain Lithium-Ion Batteries with Deep Multi-Domain Adaptation Open
View article: Altered amide proton transfer weighted and diffusion signals in patients with multiple sclerosis: correlation with neurofilament light chain and disease duration
Altered amide proton transfer weighted and diffusion signals in patients with multiple sclerosis: correlation with neurofilament light chain and disease duration Open
Objectives To compare the signal alterations of amide proton transfer (APT), apparent diffusion coefficient (ADC), and fractional anisotropy (FA) in white matter (WM) lesions in multiple sclerosis (MS), compared with healthy controls (HCs)…
View article: Amide Proton Transfer-Weighted Imaging Detects Hippocampal Proteostasis Disturbance Induced by Sleep Deprivation at 7.0 T MRI
Amide Proton Transfer-Weighted Imaging Detects Hippocampal Proteostasis Disturbance Induced by Sleep Deprivation at 7.0 T MRI Open
Sleep deprivation leads to hippocampal injury. Proteostasis disturbance is an important mechanism linking sleep deprivation and hippocampal injury. However, identifying noninvasive imaging biomarkers for hippocampal proteostasis disturbanc…
View article: Quantitative morphometric changes in vascular mild cognitive impairment patients: early diagnosis of dementia
Quantitative morphometric changes in vascular mild cognitive impairment patients: early diagnosis of dementia Open
Vascular mild cognitive impairment (VMCI) is an early and reversible stage of dementia. Volume differences in regional gray matter may reveal the development and prognosis of VMCI. This study selected 2 of the most common types of VMCI, na…
View article: Peripheral enthesitis assessed by whole-body MRI in axial spondyloarthritis: Distribution and diagnostic value
Peripheral enthesitis assessed by whole-body MRI in axial spondyloarthritis: Distribution and diagnostic value Open
Objective To determine the distribution and diagnostic value of peripheral enthesitis detected by whole-body MRI (WBMRI) in axial spondyloarthritis (axSpA) diagnosis, and to determine the value of the peripheral enthesitis score in axSpA a…
View article: Glutamate Chemical Exchange Saturation Transfer (GluCEST) Magnetic Resonance Imaging of Rat Brain With Acute Carbon Monoxide Poisoning
Glutamate Chemical Exchange Saturation Transfer (GluCEST) Magnetic Resonance Imaging of Rat Brain With Acute Carbon Monoxide Poisoning Open
Objectives To evaluate the diagnostic and prognostic values of glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging as a quantitative method for pathogenetic research and clinical application of carbon monox…
View article: Hepatic fat quantification of magnetic resonance imaging whole-liver segmentation for assessing the severity of nonalcoholic fatty liver disease: comparison with a region of interest sampling method
Hepatic fat quantification of magnetic resonance imaging whole-liver segmentation for assessing the severity of nonalcoholic fatty liver disease: comparison with a region of interest sampling method Open
Due to inclusion of the intrahepatic vasculature, whole-liver segmentation has some effects on hepatic FF assessment in patients with different NAFLD severities; yet, it does not significantly affect the assessment of whole-liver FF in MRI…
View article: Reduced Cerebral Glucose Uptake in an Alzheimer’s Rat Model With Glucose-Weighted Chemical Exchange Saturation Transfer Imaging
Reduced Cerebral Glucose Uptake in an Alzheimer’s Rat Model With Glucose-Weighted Chemical Exchange Saturation Transfer Imaging Open
A correlation between the abnormal cerebral glucose metabolism and the progression of Alzheimer’s disease (AD) has been found in previous studies, suggesting that glucose alterations may be used to predict the histopathological diagnosis i…
View article: Healthy individuals <i>vs</i> patients with bipolar or unipolar depression in gray matter volume
Healthy individuals <i>vs</i> patients with bipolar or unipolar depression in gray matter volume Open
Using VBM, the present study revealed that patients with UD and BD have different patterns of changes in GMV when compared with healthy controls.
View article: Evaluation of bone marrow infiltration in multiple myeloma using whole-body diffusion-weighted imaging and T1-weighted water- fat separation Dixon
Evaluation of bone marrow infiltration in multiple myeloma using whole-body diffusion-weighted imaging and T1-weighted water- fat separation Dixon Open
The ADC value combined with water-fat separation parameters could be used for evaluating thoracolumbar bone marrow infiltration in MM. All parameters correlated with the proportion of BMPC, which helped assess the early response in MM ther…
View article: Broad Learning Enhanced 1H-MRS for Early Diagnosis of Neuropsychiatric Systemic Lupus Erythematosus
Broad Learning Enhanced 1H-MRS for Early Diagnosis of Neuropsychiatric Systemic Lupus Erythematosus Open
In this paper, we explore the potential of using the multivoxel proton magnetic resonance spectroscopy (1H-MRS) to diagnose neuropsychiatric systemic lupus erythematosus (NPSLE) with the assistance of a support vector machine broad learnin…
View article: Maternal separation with early weaning impairs neuron-glia integrity: non-invasive evaluation and substructure demonstration
Maternal separation with early weaning impairs neuron-glia integrity: non-invasive evaluation and substructure demonstration Open
Astrocytes and oligodendrocytes play essential roles in regulating neural signal transduction along neural circuits in CNS. The perfect coordination of neuron/astrocyte and neuron/oligodendrocyte entities was termed as neuron-glia integrit…
View article: Noninvasive Detection of Extracellular pH in Human Benign and Malignant Liver Tumors Using CEST MRI
Noninvasive Detection of Extracellular pH in Human Benign and Malignant Liver Tumors Using CEST MRI Open
dual-power CEST MRI can detect extracellular pH in human liver tumors and can provide molecular-level diagnostic tools for differentiating benign and malignant liver tumors at 3T.
View article: A Novel Method for the Prenatal Diagnosis of Cleft Palate Based on Amniotic Fluid Metabolites
A Novel Method for the Prenatal Diagnosis of Cleft Palate Based on Amniotic Fluid Metabolites Open
Background and purpose: The prenatal diagnosis of cleft palate is an important component of sequential therapy, but the relevant diagnostic methods are still limited. We aimed here, to explore the possibility of an early prenatal diagnosis…
View article: Experimental study on pulse characteristics of negative corona discharge in SF6/N2 gas mixtures under DC voltages
Experimental study on pulse characteristics of negative corona discharge in SF6/N2 gas mixtures under DC voltages Open
Corona discharge, an inevitable phenomenon, may lead to insulation degradation, threatening the safe and reliable operation of gas-insulated power equipment. The pulse stage is a complex but usual discharge process in corona discharge. In …
View article: Neuron-glia Integrity: Functional Assessment, Molecular Underpinnings, and Implication for Higher Brain Functions
Neuron-glia Integrity: Functional Assessment, Molecular Underpinnings, and Implication for Higher Brain Functions Open
We developed a theory of neuron-glia integrity to underline the fact that neurons and glia cells work together in the central nervous system. Here we substantiated this theory and exemplified the implication of intact neuron-glia integrity…
View article: Diffusion Kurtosis Imaging for Detection of Early Brain Changes in Parkinson's Disease
Diffusion Kurtosis Imaging for Detection of Early Brain Changes in Parkinson's Disease Open
We aimed to evaluate microscale changes in the bilateral red nucleus and substantia nigra of patients with Parkinson's disease (PD) using diffusion kurtosis imaging (DKI). Twenty-six patients with PD [mean age, 62.5 ± 8.7 years; Hoehn-Yahr…
View article: Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo
Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo Open
View article: MiR-106a-5p modulates apoptosis and metabonomics changes by TGF-β/Smad signaling pathway in cleft palate
MiR-106a-5p modulates apoptosis and metabonomics changes by TGF-β/Smad signaling pathway in cleft palate Open
The regulatory mechanism of cleft palate was studied at transcriptional and metabolomics levels, which may provide important information in understanding the primary cause of this abnormality.
View article: Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method
Brain Amide Proton Transfer Imaging of Rat With Alzheimer’s Disease Using Saturation With Frequency Alternating RF Irradiation Method Open
Amyloid-β (Aβ) deposits and some proteins play essential roles in the pathogenesis of Alzheimer's disease (AD). Amide proton transfer (APT) imaging, as an imaging modality to detect tissue protein, has shown promising features for the diag…
View article: Multi‑organ assessment via a 9.4‑Tesla MRS evaluation of metabolites during the embryonic development of cleft palate induced by dexamethasone
Multi‑organ assessment via a 9.4‑Tesla MRS evaluation of metabolites during the embryonic development of cleft palate induced by dexamethasone Open
The aim of the present study was to determine the association between maternal metabolism and development of the fetal palate, and to suggest a potential non‑invasive prenatal diagnostic method for fetal cleft palate (CP). Dexamethasone (D…
View article: Lumbar Spinal Cord Activity and Blood Biochemical Changes in Individuals With Diabetic Peripheral Neuropathy During Electrical Stimulation
Lumbar Spinal Cord Activity and Blood Biochemical Changes in Individuals With Diabetic Peripheral Neuropathy During Electrical Stimulation Open
It is difficult to perform an in vivo evaluation of the nerve conduction mechanism in a patient with diabetic peripheral neuropathy (DPN). We aim to explore possible activation differences to enable a further understanding of the ne…